The Double Life of MCL-1
Figuring out the molecular puzzles that can change a healthy cell to a cancer cell would be difficult even if you could watch the process happen.
CT Scan For Bone Cancer Triples Accuracy
Traditionally a series of x-rays of all of the major bones in the body are used to detect myeloid myeloma , a process known as a radiographic skeletal survey. Yet in some areas, especially Europe, whole body CT is beginning to gain favor as testing indicates it is a more effective and thorough exam for measuring bone involvement in multiple myelomas , a bone-based form of leukemia. Ask your oncologist about whole body CT scanning for multiple myeloma . A formal comparison between the two imaging technologies was presented at the American Roentgen Ray Society's annual meeting by ...
Second Chance for Mylotarg
Drug development is a tricky process, and it's common for pharmaceuticals to flounder initially before their best use is discovered.
Cancer Rx Linked to Second Cancers
Health Canada, the Canadian version of the U.S. Food & Drug Administration (FDA), has issued an alert regarding the medication REVLIMID ( lenalidomide ) that's used to treat multiple myeloma .
A Better Leukemia Drug
A new drug under development for the treatment of the childhood leukemia T-ALL has had success in the first round of pharmaceutical testing. An experimental new drug known as CAL-130 is a dual enzyme inhibitor, blocking two forms of an enzyme used in the out of control growth involved in leukemia. The drug successfully stopped the enzymes phosphoinositide-3 kinase gamma and delta in testing, effectively stopping cancer growth. Ask your oncologist about clinical trials available to you. Testing of the dual inhibitor took place first in mice, and then again in samples of leuk...
Higher Dosing Doesn't Mean Better Health
It's a common concept. If one dose works well, then two doses may work even better. This theory was tested recently in patients being treated for chronic myeloid leukemia ( CML ), and it didn't work.
Gene Based Drug for Acute Myeloid Leukemia
Researchers believe that targeting the cancer gene FLT3 could cure one type of leukemia, and say results from their research explain the failure of several drugs currently used. Scientists studying the genetic relationships involved in acute myeloid leukemia have used the genetic data produced in their research to refine the search for a new drug, and testing of one candidate is underway. Ask your oncologist about clinical trials available to you. The group from the University of California in San Francisco announced that the gene FLT3 was being investigated as a possible target...
Attacking Cancer at the Root
Leukemia research has had some of the best results for effective pharmaceutical treatment, with the majority of cancers going into remission. Scientists are now researching how to best attack that remaining stubborn minority of leukemias . As a cell matures, it changes from a very basic, undifferentiated cell to developing characteristics that make it easier to recognize, and susceptible to specialized targeted drugs such as Gleevec ( imatinib ). But cells early in the development process may be unaffected by cancer treatments. Ask your oncologist about beta catenin inhibito...
Best Treatments for Childhood Leukemia
Over the last few decades, the ability of doctors to successfully treat childhood leukemias has risen dramatically. For the small group of patients that don't respond to initial therapy, figuring out why has become an important research topic.
A Double Negative Effect on Lymphoma
Cancer cells are extremely versatile and adaptable. They find ways to wiggle out of any attempts to restrain them. Researchers are working with the very mechanism that cancer uses to avoid death to develop a potentially powerful therapy for lymphoma.