Lamictal

Lamictal treats certain types of seizures and help regulate mood in those with bipolar disorder. Lamictal may cause rashes, including serious rashes that require immediate medical attention.

Lamictal Overview

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Lamictal is a prescription medication used to treat epilepsy and bipolar disorder. Lamictal belongs to a group of drugs called anticonvulsants, which decrease abnormal brain activity.

Lamictal is available as a tablet to be taken by mouth one to three times a day.

Common side effects of Lamictal include dizziness, headache, sleepiness, and tremor.

Patient Ratings for Lamictal

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  • Other
  • Bipolar Disorder
  • Epilepsies, Partial
  • Epilepsy
  • Mood Disorders
  • Seizures

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Lamictal Cautionary Labels

precautionsprecautionsprecautionsprecautionsprecautionsprecautions

Uses of Lamictal

Lamictal is a prescription medicine used together with other medicines to treat certain types of seizures in people 2 years or older.

Lamictal is also used for the treatment of bipolar disorder in people 18 years or older who have been treated for mood episodes with other medicine.

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

Manufacturer

Lamictal Drug Class

Lamictal is part of the drug class:

Side Effects of Lamictal

Serious side effects can happen with Lamictal. See Drug Precautions. 

Common side effects of Lamictal include:

  • dizziness
  • headache
  • blurred or double vision
  • lack of coordination
  • sleepiness
  • nausea, vomiting
  • insomnia
  • tremor
  • rash
  • fever
  • abdominal pain
  • back pain
  • tiredness
  • dry mouth

Tell your doctor about any side effect that bothers you or that does not go away. These are not all the possible side effects of Lamictal. For more information, ask your doctor or pharmacist.

Lamictal Interactions

Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements. Lamictal and other medicines may affect each other. Always check with your doctor before starting or stopping any medicines. Especially tell your doctor if you take:

  • valproic acid (Depakene);
  • divalproex (Depakote);
  • methotrexate (Rheumatrex, Trexall); other medications for seizures such as carbamazepine (Tegretol), oxcarbazepine (Trileptal), phenobarbital (Luminal, Solfoton), phenytoin (Dilantin), and primidone (Mysoline);
  • pyrimethamine (Daraprim);
  • rifampin (Rifadin, Rimactane);
  • trimethoprim (Proloprim);
  • hormonal contraceptives (birth control pills, patches, rings, injections, implants, or intrauterine devices)
  • hormone replacement therapy medicines (estrogens, progestins and combination medicines)

Lamictal Precautions

Lamictal can cause serious side effects such as:

Serious skin rash. Lamictal may cause a serious skin rash that may cause you to be hospitalized or even cause death.

There is no way to tell if a mild rash will become more serious. A serious skin rash can happen at any time during your treatment with Lamictal but is more likely to happen within the first 2 to 8 weeks of treatment. Children between 2 to 16 years of age have a higher chance of getting this serious skin rash while taking Lamictal.

The risk of getting a serious skin rash is higher if you:

  • take Lamictal while taking valproate [Depakene (valproic acid) or Depakote (divalproex sodium)]
  • take a higher starting dose of Lamictal than your doctor prescribed
  • increase your dose of Lamictal faster than prescribed.

Call your doctor right away if you experience a skin rash, blistering or peeling of your skin, hives, or painful sores in your mouth or around your eyes. These symptoms may be the first signs of a serious skin reaction. A doctor should examine you to decide if you should continue taking Lamictal.

Immune system reaction called hemophagocytic lymphohistiocytosis (HLH). This can cause severe inflammation throughout the body and lead to hospitalization and death. Tell your doctor immediately if you notice any of the following symptoms: fever, rash, symptoms may include pain, tenderness, or unusual swelling over the liver area in the upper right belly, swollen lymph nodes, yellow skin or eyes, unusual bleeding, or nervous system problems (seizures, trouble walking, difficulty seeing, or other visual disturbances).

Serious blood problems or liver problems. Lamictal can also cause other types of allergic reactions or serious problems that may affect organs and other parts of your body like your liver or blood cells. You may or may not have a rash with these types of reactions. Call your doctor right away if you have any of these symptoms:

  • fever
  • frequent infections
  • severe muscle pain
  • swelling of your face, eyes, lips, or tongue
  • swollen lymph glands
  • unusual bruising or bleeding
  • weakness, fatigue
  • yellowing of your skin or the white part of your eyes

Suicidal thoughts or actions. Like other antiepileptic drugs, Lamictal may cause suicidal thoughts or actions in a very small number of people, about 1 in 500.

Call a doctor right away if you have any of these symptoms, especially if they are new, worse, or worry you:

  • thoughts about suicide or dying
  • attempt to commit suicide
  • new or worse depression
  • new or worse anxiety
  • feeling agitated or restless
  • panic attacks
  • trouble sleeping (insomnia)
  • new or worse irritability
  • acting aggressive, being angry, or violent
  • acting on dangerous impulses
  • an extreme increase in activity and talking (mania)
  • other unusual changes in behavior or mood

Aseptic meningitis. Lamictal may rarely cause aseptic meningitis, a serious inflammation of the protective membrane that covers the brain and spinal cord. 

Meningitis has many causes other than Lamictal, which your doctor would check for if you developed meningitis while taking Lamictal.Call your doctor right away if you experience headache, fever, nausea/vomiting, stiff neck, rash, or unusual sensitivity to light. Other symptoms to look for include muscle pains, chills, confusion, and drowsiness. 

Patients prescribed Lamictal have sometimes been given the wrong medicine because many medicines have names similar to Lamictal, so always check that you receive Lamictal.

Do not drive a car or operate complex, hazardous machinery until you know how Lamictal affects you.

Do not stop taking Lamictal without talking to your doctor. Stopping Lamictal suddenly may cause serious problems including seizures that do not stop. Your doctor will help you to gradually decrease your dose.

Do not take Lamictal if you have had an allergic reaction to Lamictal or to any of the inactive ingredients in Lamictal. 

Lamictal Food Interactions

Medicines can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of Lamictal, there are no specific foods that you must exclude from your diet when receiving Lamictal.

Inform MD

Before taking Lamictal, tell your doctor about all of your medical conditions, including if you:

  • have had a rash or allergic reaction to another antiseizure medicine.
  • have or have had depression, mood problems or suicidal thoughts or behavior.
  • have had aseptic meningitis after taking Lamictal or Lamictal XR.
  • are taking oral contraceptives (birth control pills) or other female hormonal medicines. Do not start or stop taking birth control pills or other female hormonal medicine until you have talked with your doctor. Tell your doctor if you have any changes in your menstrual pattern such as breakthrough bleeding. Stopping these medicines may cause side effects (such as dizziness, lack of coordination, or double vision). Starting these medicines may lessen how well Lamictal works.
  • are pregnant or plan to become pregnant. It is not known if Lamictal will harm your unborn baby. If you become pregnant while taking Lamictal, talk to your doctor about registering with the North American Antiepileptic Drug Pregnancy Registry. You can enroll in this registry by calling 1-888-233-2334. The purpose of this registry is to collect information about the safety of antiepileptic drugs during pregnancy.
  • are breastfeeding. Lamictal passes into breast milk and may cause side effects in a breastfed baby. If you breastfeed while taking Lamictal, watch your baby closely for trouble breathing, episodes of temporarily stopping breathing, sleepiness, or poor sucking. Call your baby’s doctor right away if you see any of these problems. Talk to your doctor about the best way to feed your baby if you take Lamictal.

Lamictal and Pregnancy

Tell your doctor if you are pregnant or plan to become pregnant. It is not known if Lamictal will harm your unborn baby.

Lamictal and Lactation

Tell your doctor if you are breastfeeding or planning to breastfeed. Lamictal passes into breast milk and may cause side effects in a breastfed baby. If you breastfeed while taking Lamictal, watch your baby closely for trouble breathing, episodes of temporarily stopping breathing, sleepiness, or poor sucking. Call your baby’s healthcare provider right away if you see any of these problems. Talk to your healthcare provider about the best way to feed your baby if you take Lamictal. 

Lamictal Usage

  • Take Lamictal exactly as prescribed.
  • Your healthcare provider may change your dose. Do not change your dose without talking to your healthcare provider.
  • Do not stop taking Lamictal without talking to your healthcare provider. Stopping Lamictal suddenly may cause serious problems. For example, if you have epilepsy and you stop taking Lamictal suddenly, you may get seizures that do not stop. Talk with your healthcare provider about how to stop Lamictal slowly.
  • If you miss a dose of Lamictal, take it as soon as you remember. If it is almost time for your next dose, just skip the missed dose. Take the next dose at your regular time. Do not take two doses at the same time.
  • You may not feel the full effect of Lamictal for several weeks.
  • If you have epilepsy, tell your healthcare provider if your seizures get worse or if you have any new types of seizures.
  • Swallow Lamictal tablets whole.
  • If you have trouble swallowing Lamictal tablets, tell your healthcare provider because there may be another form of Lamictal you can take.
  • Lamictal ODT should be placed on the tongue and moved around the mouth. The tablet will rapidly disintegrate, can be swallowed with or without water, and can be taken with or without food.
  • Lamictal Chewable Dispersible tablets may be swallowed whole, chewed, or mixed in water or diluted fruit juice. If the tablets are chewed, drink a small amount of water or diluted fruit juice to help in swallowing. To break up Lamictal Chewable Dispersible tablets, add the tablets to a small amount of liquid (1 teaspoon, or enough to cover the medicine) in a glass or spoon. Wait at least 1 minute or until the tablets are completely broken up, mix the solution together and take the whole amount right away.
  • If you receive Lamictal in a blister pack, examine the blister pack before use. Do not use if blisters are torn, broken, or missing.

Lamictal Dosage

Take Lamictal exactly as prescribed by your doctor. Follow the directions on your prescription label carefully. Your doctor will determine the best dose for you. Often patients begin taking a low dose for the first 2 weeks and that is followed by a dose increase for weeks 3 and 4. Then from week 5 on, a dose increase every 1 to 2 weeks is added until the best dose is achieved. 

Lamictal Overdose

If you take too much Lamictal call your local Poison Control Center or seek emergency medical attention right away.

Other Requirements

  • Store Lamictal at room temperature between 68 F to 77 F (20 C to 25 C).
  • Keep Lamictal and all medicines out of the reach of children.

Lamictal FDA Warning

WARNING: SERIOUS SKIN RASHES                                                           

Lamictal can cause serious rashes requiring hospitalization and discontinuation of treatment. The incidence of these rashes, which have included Stevens-Johnson syndrome, is approximately 0.8% (8 per 1,000) in pediatric patients (2 to 16 years of age) receiving Lamictal as adjunctive therapy for epilepsy and 0.3% (3 per 1,000) in adults on adjunctive therapy for epilepsy. In clinical trials of bipolar and other mood disorders, the rate of serious rash was 0.08% (0.8 per 1,000) in adult patients receiving Lamictal as initial monotherapy and 0.13% (1.3 per 1,000) in adult patients receiving Lamictal as adjunctive therapy. In a prospectively followed cohort of 1,983 pediatric patients (2 to 16 years of age) with epilepsy taking adjunctive Lamictal, there was 1 rash-related death. In worldwide postmarketing experience, rare cases of toxic epidermal necrolysis and/or rash-related death have been reported in adult and pediatric patients, but their numbers are too few to permit a precise estimate of the rate.

Other than age, there are as yet no factors identified that are known to predict the risk of occurrence or the severity of rash caused by Lamictal. There are suggestions, yet to be proven, that the risk of rash may also be increased by (1) coadministration of Lamictal with valproate (includes valproic acid and divalproex sodium), (2) exceeding the recommended initial dose of Lamictal, or (3) exceeding the recommended dose escalation for Lamictal. However, cases have occurred in the absence of these factors.

Nearly all cases of life-threatening rashes caused by Lamictal have occurred within 2 to 8 weeks of treatment initiation. However, isolated cases have occurred after prolonged treatment (e.g., 6 months). Accordingly, duration of therapy cannot be relied upon as means to predict the potential risk heralded by the first appearance of a rash.

Although benign rashes are also caused by Lamictal, it is not possible to predict reliably which rashes will prove to be serious or life threatening. Accordingly, Lamictal should ordinarily be discontinued at the first sign of rash, unless the rash is clearly not drug related. Discontinuation of treatment may not prevent a rash from becoming life threatening or permanently disabling or disfiguring.