ZTlido

ZTlido is a non-opioid treatment option for post-shingles pain. It is a topical patch that can be left on the body for up to 12 hours at a time.

ZTlido Overview

Reviewed: March 5, 2018
Updated: 

ZTlido is a prescription medication used to treat pain associated with post-herpetic neuralgia (pain that lasts for months or years after a shingles infection). 

ZTlido belongs to a group of drugs called local anesthetics. These work by stopping nerves from sending pain signals.

This medication comes in topical patch form and is applied to the skin once daily. ZTlido may be left on the skin for up to 12 hours in a 24 hour period (12 hours on and 12 hours off). It should be applied to intact skin to cover the most painful area. 

Common side effects of ZTlido include application site reactions such as skin irritation, itching and redness. 

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Uses of ZTlido

ZTlido is a prescription medication used to treat pain associated with post-herpetic neuralgia (pain that lasts for months or years after a shingles infection). This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

ZTlido Drug Class

ZTlido is part of the drug class:

Side Effects of ZTlido

Serious side effects have been reported with ZTlido. See the “ZTlido Precautions” section.

Common side effects of ZTlido include the following:

  • skin irritation
  • redness
  • itching

This is not a complete list of ZTlido side effects. Ask your doctor or pharmacist for more information.

Tell your doctor if you have any side effects that bother you or that do not go away.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

ZTlido Interactions

Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you take:

  • Antiarrhythmic drugs such as disopyramide (Norpace), flecainide (Tambocor), mexiletine (Mexitil), moricizine (Ethmozine), procainamide (Procanabid, Pronestyl), propafenone (Rhythmol), quinidine (Quinidex) and tocainide (Tonocard)
  • Local anesthetics such as bupivacaine (Marcaine), etidocaine (Duranest), mepivacaine (Carbocaine, Prolocaine) or prilocaine (Citanest)

This is not a complete list of ZTlido drug interactions. Ask your doctor or pharmacist for more information.

ZTlido Precautions

Serious side effects have been reported with ZTlido including the following:

  • Hypersensitivity (allergic) reactions. Tell your healthcare provider right away if you have symptoms of an allergic reaction, such as swelling or shortness of breath.
  • Application site reactions. Tell your healthcare provider right away if you have some or all of the following symptoms of application site reactions, such as blisters, bruising, burning, swelling, redness, irritation, peeling or flaking of the skin or discoloration. 
  • Severe eye irritation. Avoid touching your eyes with your hands or fingers after applying or removing ZTlido. Wash your hands right away after handling ZTlido. Tell your healthcare provider right away if ZTlido comes in contact with your eye and wash out your eye with water or saline right away.

Do not take ZTlido if you:

  • are allergic to ZTlido or to any of its ingredients
  • are allergic to other numbing agents (anesthetics)

ZTlido Food Interactions

Medications can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of ZTlido, there are no specific foods that you must exclude from your diet when receiving this medication.

Inform MD

Before taking ZTlido, tell your doctor about all of your medical conditions. Especially tell your doctor if you:

  • are allergic to ZTlido or to any of its ingredients
  • have liver problems 
  • are allergic to para-aminobenzoic acid (PABA) medicines such as procaine, tetracaine or benzocaine
  • are pregnant or plan to become pregnant
  • are breastfeeding or plan to breastfeed

Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements.

ZTlido and Pregnancy

Tell your doctor if you are pregnant or plan to become pregnant.

The FDA categorizes medications based on safety for use during pregnancy. Five categories - A, B, C, D, and X, are used to classify the possible risks to an unborn baby when a medication is taken during pregnancy.

ZTlido falls into category B. There are no well-done studies that have been done in humans with ZTlido. In animal studies, pregnant animals were given this medication, and the babies did not show any medical issues related to this medication.

ZTlido and Lactation

Tell your doctor if you are breastfeeding or plan to breastfeed.

ZTlido has been detected in human breast milk. Because of the possibility for adverse reactions in nursing infants from ZTlido, a choice should be made whether to stop nursing or to stop use of this medication. The importance of the drug to the mother should be considered.

ZTlido Usage

Use ZTlido exactly as prescribed.

ZTlido comes in a topical patch form and is usually applied once a day and left on the skin for a maximum of 12 hours in a 24 hour period (12 hours on and 12 hours off). ZTlido should only be applied to intact skin (skin that is not cut, scraped, burned or irritated). Wash your hands immediately after applying or handling ZTlido.

Avoid bathing, swimming or showering while wearing ZTlido, since it may not stick if it gets wet.

Do not apply external heat sources (heating pads or electric blankets) directly on ZTlido. 

If a burning or stinging sensation occurs during application, remove ZTlido and do not reapply it until the burning or stinging resolves. 

If you miss a dose, take the missed dose as soon as you remember. If it is almost time for the next dose, skip the missed dose and take your next dose at the regular time. Do not take two doses of ZTlido at the same time.

ZTlido Dosage

Take this medication exactly as prescribed by your doctor. Follow the directions on your prescription label carefully.

The dose your doctor recommends may be based on the following:

  • other medical conditions you have
  • other medications you are taking
  • how you respond to this medication

The recommended dose of ZTlido for the treatment of post-herpetic neuralgia (pain that lasts for months or years after a shingles infection) is 1 to 3 patches applied to intact skin to cover the most painful area once a day for a maximum of 12 hours in a 24 hour period (12 hours and 12 hours off).

ZTlido Overdose

If you use more than 3 ZTlido patches or leave ZTlido on your skin for more than 12 hours, call your healthcare provider or local Poison Control Center, or seek emergency medical attention right away.

Other Requirements

  • Store ZTlido at room temperature between 68°F to 77°F (20°C to 25°C).
  • Keep ZTlido topical system in the original packaging unit until ready for use.
  • Discard ZTlido by removing it from your skin and folding the patch so that the sticky sides stick together. Throw away the used ZTlido patches in a safe place where children and pets cannot get to them. Wash your hands immediately after removing ZTlido. 
  • Keep ZTlido and all medicines out of the reach of children, pets and others.