Zegerid OTC

Purpose of Zegerid OTC

Zegerid OTC is an over-the-counter medication used to treat heartburn that occurs 2 or more days a week.

Active Ingredients

Omeprazole 20 mg and sodium bicarbonate 1100 mg

Inactive Ingredients

Croscarmellose sodium, FD&C blue No. 1, gelatin, magnesium stearate, pharmaceutical ink, polysorbate 80, titanium dioxide

Zegerid OTC FDA Warning

Allergy Alert: do not use if you are allergic to omeprazole or any other ingredients of Zegerid OTC.

Do not use if you have: 

  • pain or trouble swallowing
  • vomiting with blood
  • bloody or black stools

These may be signs of a serious condition. If you are experiencing any of these symptoms, seek medical attention right away.

Consult a physician before use if you have:

  • had heartburn for over 3 months (this may be a sign of a more serious condition)
  • heartburn with lightheadedness, sweating or dizziness
  • chest or shoulder pain along with shortness of breath, sweating, pain spreading to the arms, neck or shoulders, or lightheadedness
  • frequent chest pain
  • frequent wheezing, along with heartburn symptoms
  • unexplained weight loss
  • nausea or vomiting
  • stomach pain
  • a sodium-restricted diet

Consult a physician or pharmacist before use if you are taking:

  • Coumadin (warfarin), Plavix (clopidogrel), or Pletal (cilostazol)
  • prescription antifungal or anti-yeast medications
  • Valium (diazepam) - anxiety medication
  • Lanoxin (digoxin) - heart medication
  • Prograf (tacrolimus) - immune system medication
  • prescription HIV medications
  • any other prescription medications, a component of Zegerid OTC may interact with certain medications

Stop use and consult a physician if:

  • your heartburn continues or worsens
  • you need to use this product for more than 14 days
  • you need to take more than 1 course of treatment every 4 months

If pregnant or breastfeeding, consult a health professional before use.

Keep out of reach of children.

In case of overdose, get medical help or contact a Poison Control Center right away (1-800-222-1222).


For adults 18 years of age and older:

  • This product is to be used once daily (every 24 hours), every day for 14 days.
  • Allow up to 4 days for full effect, although some people may get complete relief within 24 hours.

14-Day Therapy Course

  • Take one capsule at least 60 minutes before eating in the morning.
  • Take daily for 14 days.
  • Do not take more than 1 capsule in 24 hours
  • Do not crush, chew, or open capsule and sprinkle on food.
  • Do not use for more than 14 days unless directed by a physician.

Repeated 14-day Therapy Course (if needed)

  • You may repeat a 14-day course every 4 months.
  • Do not take for more than 14 days or more often than every 4 months unless directed by a physician.

Pediatric Use

For children under 18 years of age, ask a doctor.

Heartburn in children may sometimes be caused by a serious condition.

Other Information About Zegerid OTC

  • Each capsule contains 303 mg of sodium.
  • Read the directions, warnings, and accompanying label information before use.
  • Store at room temperature between 20°-25°C (68°-77°F) in a cool, dry place.
  • Keep product out of high heat, humidity and moisture.
  • Tamper-evident. Do not use if:
    • blue band around the capsule is missing or broken
    • foil under cap, printed with “Sealed for your protection” is missing, open or broken