Yupelri

Yupelri is used for the maintenance of chronic obstructive pulmonary disease (COPD). Yupelri is inhaled via a nebulizer machine, once daily.

Yupelri Overview

Reviewed: December 2, 2018
Updated: 

Yupelri is a prescription medication used for the maintenance treatment of chronic obstructive pulmonary disease (COPD) a long-term (chronic) lung disease that includes chronic bronchitis, emphysema, or both.

Yupelri belongs to a group of drugs called long-acting muscarinic antagonists, which are often referred to as anticholinergics. These medications work through inhibition of M3 receptor at the smooth muscle leading to bronchodilation.

Yupelri comes as a solution for oral inhalation. The recommended once-daily dose is one 175 mcg unit-dose vial administered by nebulizer using a mouthpiece. Yupelri should be administered by the orally inhaled route via a standard jet nebulizer connected to an air compressor.

Common side effects include cough, runny nose, upper respiratory tract infection, headache and back pain.

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Uses of Yupelri

Yupelri is a prescription medicine used to treat chronic obstructive pulmonary disease (COPD), a long-term (chronic) lung disease that includes chronic bronchitis, emphysema, or both.

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

Revefenacin

For more information on this medication choose from the list of selections below.

Yupelri Drug Class

Side Effects of Yupelri

Serious side effects have been reported with Yupelri. See the “Yupelri Precautions” section.

Common side effects of Yupelri include the following:

  • Cough
  • Headache
  • Common cold
  • Upper respiratory tract injection
  • Back pain

This is not a complete list of Yupelri side effects. Ask your doctor or pharmacist for more information. Tell your doctor if you have any side effects that bother you or that do not go away. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Yupelri Interactions

Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you take:

This is not a complete list of Yupelri drug interactions. Ask your doctor or pharmacist for more information.

Yupelri Precautions

Serious side effects have been reported with Yupelri including the following:

  • Sudden breathing problems immediately after inhaling your medicine. If you have sudden breathing problems immediately after inhaling your medicine, stop using Yupelri and call your healthcare provider right away.
  •  New or worsened eye problems including acute narrow-angle glaucoma. Acute narrow-angle glaucoma can cause permanent loss of vision if not treated. Symptoms may include:
    •  Red eyes
    •  Blurred vision
    •  Seeing halos or bright colors around lights
    •  Eye pain or discomfort
    •  Nausea or vomiting
  •  Urinary retention. People who take Yupelri may develop new or worse urinary retention. Symptoms of urinary retention may include:
    •  difficulty urinating
    •  urinating frequently
    •  urination in a weak stream or drips
    •  painful urination

If you have any of these symptoms, call your healthcare provider right away before taking another dose.

  •  Serious allergic reactions. Call your healthcare provider or get emergency medical care if you get any of the following symptoms of a serious allergic reaction:
    •  rash
    •  hives
    •  severe itching
    •  swelling of your face, mouth, and tongue
    •  difficulty breathing or swallowing

If you have any of these symptoms, stop taking Yupelri, and call your healthcare provider right away before taking another dose.

  • Do not use Yupelri if you have sudden breathing problems. Always have a rescue inhaler with you.
  • Do not use Yupelri if you have had an allergic reaction to revefenacin, or any of the other ingredients in Yupelri (sodium chloride, citric acid, sodium citrate).
  • Do not use in children. It is not known if Yupelri is safe and effective in children.

Yupelri Food Interactions

Medications can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of Yupelri, there are no specific foods that you must exclude from your diet when receiving this medication.

Inform MD

Before taking Yupelri, tell your doctor about all of your medical conditions. Especially tell your doctor if you:

  • have eye problems such as glaucoma. Yupelri may make your glaucoma worse.
  • have prostate or bladder problems, or problems passing urine. Yupelri may make these problems worse.
  • have liver problems.
  • are allergic to any of the ingredients in Yupelri, or any other medicines.
  • are pregnant or planning to become pregnant. It is not known if Yupelri may harm your unborn baby.
  • are breastfeeding. It is not known if the medicine in Yupelri passes into your breast milk and if it can harm your baby.

Tell your healthcare provider about all the medicines you take including prescription and over-the-counter medicines, vitamins, and herbal supplements. Yupelri and certain other medicines may interact with each other. This may cause serious side effects.

Yupelri and Pregnancy

Tell your doctor if you are pregnant or plan to become pregnant.

There are no well-done studies that have been done in humans with Yupelri. In animal studies, pregnant animals were given this medication, and the babies did not show any medical issues related to this medication. Talk to your doctor to see if Yupelri can work for you.

Yupelri and Lactation

Tell your doctor if you are breastfeeding or plan to breastfeed.

It is not known if Yupelri crosses into human milk. Because many medications can cross into human milk and because of the possibility for serious adverse reactions in nursing infants with use of this medication, a choice should be made whether to stop nursing or stop the use of this medication. Your doctor and you will decide if the benefits outweigh the risk of using Yupelri.

Yupelri Usage

Take Yupelri exactly as prescribed.

  • Yupelri is only for use with a nebulizer.
  • Do not use Yupelri more often than prescribed.
  • Do not mix Yupelri with other medicines in your nebulizer.
  • Do not use other medicines that contain an anticholinergic for any reason. 
  • If you miss a dose, take the missed dose as soon as you remember. If it is almost time for the next dose, skip the missed dose and take your next dose at the regular time. Do not take two doses of Yupelri at the same time.
  • Do not stop using Yupelri, even if you are feeling better, unless your healthcare provider tells you to because your symptoms might get worse.
  • Call your healthcare provider or get emergency medical care right away if:
    •  your breathing problems get worse.
    •  you need to use your rescue inhaler medicine more often than usual.
    •  your rescue inhaler medicine does not relieve your symptoms.

Yupelri Dosage

Take this medication exactly as prescribed by your doctor. Follow the directions on your prescription label carefully.

The dose your doctor recommends may be based on the following:

  • the condition being treated
  • other medical conditions you have
  • other medications you are taking
  • how you respond to this medication

The recommended dose of Yupelri (revefenacin) for the maintenance of chronic obstructive pulmonary disease (COPD) is 175 mcg ( 1 unit dose vial) once daily.

Yupelri Overdose

If you take too much Yupelri, call your healthcare provider or local Poison Control Center, or seek emergency medical attention right away.

Other Requirements

Store Yupelri at room temperature.

Only remove Yupelri from the foil pouch immediately before use.

Keep this and all medicines out of the reach of children.