A third hormonal treatment for endometriosis is medroxy-progesterone, which is branded as Depo-Provara. This injectable drug contains progestin, a hormone that works AGAINST the effects of estrogen on endometrial tissue. Depo-Propvara also stops the menstrual cycle and may cause other symptoms like weight gain, depression, and decreased bone density. Finally, a weak male hormone called Danazol may be used to treat painful endometriosis. Danazol lowers the levels of estrogen and progesterone in a woman's body. Unfortunately, it may also cause unwanted and unavoidable side effects, including: facial hair growth, diminished breast size, oily skin, and weight gain.