Purpose of Unisom

Unisom SleepGels and Unisom SleepMelts are over-the-counter medications used to relieve temporary sleeplessness and reduce the difficulty in falling asleep.


Active Ingredients

Unisom SleepGels: Diphenhydramine hydrochloride 50 mg

Unisom SleepMelts: Diphenhydramine hydrochloride 25 mg

Inactive Ingredients

Unisom SleepGels: Blue 1, gelatin, glycerin, polyethylene glycol, polyvinyl acetate phthalate, propylene glycol, sorbitol, titanium dioxide, water (245-189)

Unisom SleepMelts: Citric acid, ethylcellulose, flavor, hydroxypropyl cellulose, mannitol, microcrystalline cellulose, PVP, red 7, starch, sucralose, sucrose (245-236)

Unisom FDA Warning

Do not use:
  • for children under 12 years of age
  • with any other product containing diphenhydramine, even one used on skin
Ask a doctor before use if you have:
  • a breathing problem such as emphysema or chronic bronchitis
  • glaucoma
  • trouble urinating due to an enlarged prostate gland

Ask a doctor or pharmacist before use if you are taking sedatives or tranquilizers.

When using this product avoid alcoholic drinks.

Stop use and ask a doctor if sleeplessness persist continuously for more than 2 weeks. Insomnia may be a symptom of serious underlying medical illness.

If pregnant or breastfeeding, ask a health professional before use.

Keep out of reach of children.

In case of overdose, get medical help or contact a Poison Control Center right away (1-800-222-1222).



Unisom SleepGels:

Adults and children 12 years of age and over: 1 softgel (50 mg) at bedtime if needed, or as directed by a doctor.

Unisom SleepMelts:

Adults and children 12 years of age and over:

  • Take 2 SleepMelts (25 mg each) at bedtime if needed, or as directed by a doctor.
  • Place 2 SleepMelts on tongue. Tablets dissolve with or without water.
  • Allow SleepMelts to dissolve in mouth or chew before swallowing.

Pediatric Use

Unisom SleepGels and Unisom SleepMelts: For children under 12 years of age, do not use.