Takhzyro treats patients 12 years of age and older with type I and II hereditary angioedema (HAE). Takhzyro is injected under the skin (subcutaneously) every 2 weeks.

Takhzyro Overview

Reviewed: September 17, 2018

Takhzyro is a prescription medication used to prevent attacks of Hereditary Angioedema (HAE) in people 12 years of age and older. 

Takhzyro belongs to a group of drugs called therapeutic antibodies. It works by targeting a substance in the body known as kallikrein, which is overactive in people with HAE. By targeting kallikrein, bradykinin release is controlled, bringing levels closer to normal to prevent HAE attacks.

This medication comes in a single-dose vial as a ready-to-use solution. It is given every 2 weeks as an injection under your skin (subcutaneous) by you or a caregiver.

Common side effects include injection site reactions (like pain, bruising, redness, and rash), upper respiratory infections, and headache.

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Uses of Takhzyro

Takhzyro is a prescription medication used to prevent attacks of type I and II hereditary angioedema (HAE) in people 12 years of age and older. HAE is rare hereditary disease that can cause attacks of swelling and pain in parts of the body.

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.


For more information on this medication choose from the list of selections below.

Takhzyro Drug Class

Takhzyro is part of the drug class:

Side Effects of Takhzyro

Serious side effects have been reported with Takhzyro. See the “Drug Precautions” section.

Common side effects of Takhzyro include:

  • injection site reactions (pain, bruising, redness)
  • upper respiratory infections
  • headache

This is not a complete list of Takhzyro side effects. Ask your doctor or pharmacist for more information. Tell your doctor if you have any side effects that bothers you or that does not go away. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Takhzyro Interactions

No Takhzyro drug interactions have been studied by the manufacturer. However, you should tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements. Not all drug interactions are known or reported and new drug interactions are continually being reported.

Takhzyro Precautions

Serious side effects have been observed with Takhzyro including hypersensitivity reactions.  Tell your healthcare provider or get emergency help right away if you have any of the following symptoms:

  • wheezing
  • difficulty breathing
  • chest tightness
  • fast heartbeat
  • faintness
  • rash
  • hives

Do not take this medication if you are allergic to this medication or to any of its ingredients.

Takhzyro Food Interactions

Medications can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of Takhzyro, there are no specific foods that you must exclude from your diet when receiving this medication.

Inform MD

Before you use Takhzyro, tell your healthcare provider about all of your medical conditions, including if you:

  • are pregnant or planning to become pregnant. It is not known if Takhzyro can harm your unborn baby.
  • are breastfeeding or plan to breastfeed. It is not known if Takhzyro passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby while using Takhzyro.

Tell your healthcare provider about all the medicines you take, including prescription medicines, over-the-counter medicines, vitamins, or herbal supplements.

Takhzyro and Pregnancy

Tell your doctor if you are pregnant or plan to become pregnant.

There are no well-controlled studies that have been done in pregnant women. Takhzyro should be used during pregnancy only if the possible benefit outweighs the possible risk to the unborn baby. In animal studies, pregnant animals were given this medication, and the offspring did not show any medical issues related to this medication.

Takhzyro and Lactation

Tell your doctor is you are breastfeeding or plan to breastfeed.

It is not known if Takhzyro crosses into human milk. Because many medications can cross into human milk and because of the possibility for serious adverse reactions in nursing infants with use of this medication, your doctor will determine if it is safe to breastfeed or continue to breastfeed while taking this medication. 

Takhzyro Usage

A healthcare provider should show you how to prepare and inject Takhzyro properly before you use it for the first time. Contact your healthcare provider if you have any questions.

Administer Takhzyro exactly as prescribed.

  • Takhzyro is a ready-to-use solution for injection under the skin (subcutaneous). It is supplied in a single-dose, glass vial.
  • Your healthcare provider will prescribe the dose that you should take.
  • Only use the syringes, transfer needles, and injection needles that your healthcare provider prescribes.
  • Only use the syringes, transfer needles and injection needles 1 time. Throw away (dispose of) any used syringes and needles.

STEP 1: Prepare for your injection

  • Gather all supplies and place them on a well-lighted flat work surface.
  • Take the vial out of the refrigerator 15 minutes before use and allow it to reach room temperature before preparing an injection.
  • Check the expiration date on the box and vial label of Takhzyro. Do not use if the expiration date has passed.
  • Check the supplies for damage. Do not use if they appear damaged.
  • Clean your work area and wash your hands before preparing your dose. Do not touch any surface or body part, especially your face, after washing your hands before injection.
  • Remove the vial from the packaging. Do not use the vial if the plastic cap covering is missing.
  • Gently turn the vial upside down (invert) 3 to 5 times to mix the medicine. Do not shake to avoid foaming.
  • Look at the medicine in the vial for visible particles or a change in the color. Medicine should be colorless to slightly yellow. Do not use if you see particles or a change in color. Important: Do not shake.
  • Remove the plastic cap from the medicine vial. Do not remove the medicine vial rubber stopper.
  • Place the vial on a flat surface. Clean the medicine vial rubber stopper with an alcohol wipe and allow it to dry.

STEP 2: Attach transfer needle to syringe

  • Screw the 18G transfer needle to the 3mL syringe. Important: Do not remove the transfer needle cap from the needle when attaching to the syringe. 
  • Pull back the plunger to fill the syringe with air equal to the amount of medicine in the vial.
  • Hold the syringe by the barrel with one hand and the transfer needle cap with the other hand.
  • Pull off the transfer needle cap straight away from the syringe and away from your body. Do not pull on the plunger. Place the transfer needle cap down on a clean flat surface.
  • Do not touch the needle tip.

STEP 3: Transfer Takhzyro into syringe and switch to the injection needle

  • Keep the vial on the flat surface and insert the transfer needle into the center of the rubber stopper.
  • Push the plunger down to inject air into the vial and hold the plunger down. 
  • Slowly turn the vial upside down with transfer needle and syringe attached. Pull back on the plunger to withdraw the full dose in the vial. Important: Be sure to keep the tip of the transfer needle in the medicine to avoid drawing air in as you pull back the plunger. 
  • Remove large air bubbles by gently tapping on the syringe barrel with your fingers until the bubbles rise to the top of the syringe.
  • Slowly push the plunger, allowing air to go back into the vial, until the medicine reaches the top of the syringe.
  • Repeat these steps until large air bubbles are removed. Important: Check again to make sure you have the right amount of medicine in your syringe. If you do not have enough medicine, pull back on the plunger again while keeping the needle in the medicine to get your full dose. 
  • Return the vial to an upright position.
  • Without removing the needle from the vial, unscrew the syringe by holding the needle hub and turning the syringe counter clockwise.
  • Return the syringe to an upright position.
  • Throw away the 18G transfer needle and the vial in a sharps disposal container. 
  • Screw the 27G ½-inch injection needle to the syringe. Important: Do not remove the needle cap from the injection needle when attaching to the syringe. Do not use the transfer needle to inject Takhzyro as this may cause harm such as pain and bleeding.

STEP 4: Select and prepare injection site

  • Takhzyro can be self-injected in your stomach (abdomen) or thigh. If given by a caregiver, Takhzyro may also be injected in the upper arm.
  • Clean your injection site with an alcohol wipe and allow it to dry completely.


  • You should use a different injection site each time you receive an injection to keep your skin healthy.
  • The area you choose for injection should be at least 2 inches (5 cm) away from any scars or your belly button (navel). Do not choose an area that is bruised, swollen, or painful.
  • Takhzyro should be given within 2 hours of preparing the dosing syringe at room temperature. After the dosing syringe is prepared, it can be refrigerated at 36°F to 46°F (2°C to 8°C) and must be used within 8 hours of preparation. Take the dosing syringe out of the refrigerator 15 minutes before use and allow it to reach room temperature prior to injecting.

STEP 5: Inject Takhzyro

  • Hold the syringe by the barrel with one hand and the injection needle cap with the other hand.
  • Pull off the injection needle cap straight away from the syringe and away from your body. Do notpull on the plunger. Do not touch the needle tip or allow it to touch any other surface. 
  • Gently pinch about 1 inch of skin at your cleaned chosen injection site and insert the needle. Important: Be sure to inject under the skin which is not too shallow (skin layer) or too deep (muscle). 
  • Push the plunger slowly until no medicine remains in the syringe. Release the skin fold and gently remove the needle. Do not recap the needle.


  • Place the 27G ½-inch Injection needle and the syringe in a sharps container.
  • If you do not have a FDA-cleared sharps disposal, you may use a household container that is:
    • Made of heavy-duty plastic,
    • Can be closed with a tight fitting, puncture-resistant lid, without sharps being able to come out,
    • Upright and stable during use,
    • Leak-resistant, and
  • Properly labeled to warn of hazardous waste inside the container.
  • When your sharps disposal container is almost full, you will need to follow your community guidelines for the right way to dispose of your sharps disposal container. There may be state or local laws about how you should throw away used needles and syringes. 
    Important: Always keep the sharps disposal container out of the reach of children.

Takhzyro Dosage

Take this medication exactly as prescribed by your doctor. Follow the directions on your prescription label carefully.

The dose your doctor recommends may be based on the following:

  • the condition being treated
  • other medical conditions you have
  • other medications you are taking
  • how you respond to this medication
  • your weight
  • your height
  • your age
  • your gender

The recommended dose of Takhzyro for attacks associated with HAE in patients 12 years and older is 300 mg every 2 weeks. Dosing every 4 weeks may be considered in some patients.

Takhzyro Overdose

If you take too much Takhzyro, call your healthcare provider or local Poison Control Center, or seek emergency medical attention right away.

Other Requirements

  • Store Takhzyro in the refrigerator at 36°F to 46°F (2°C to 8°C). Do not freeze.
  • Store Takhzyro in the original carton to protect the vial from light.
  • Do not shake Takhzyro.
  • Keep Takhzyro and all medicines out of the reach of children.

This page was written by Joelle Orendain, PharmD Candidate 2020 | UT Austin College of Pharmacy