Skyrizi treats plaque psoriasis in adults. Treatment may increase your risk of infection.

Skyrizi Overview

Reviewed: April 26, 2019

Skyrizi is a prescription medication used to treat plaque psoriasis in adults. 

Skyrizi belongs to a group of drugs called monoclonal antibodies that target specific molecules in the body known to play a role in disease. While the exact cause of plaque psoriasis is unknown, your body may produce too much of a protein called IL-23. IL-23 is one of several proteins that may contribute to excess inflammation inside the body, which can lead to painful, red, itchy, burning plaques on the skin. Skyrizi works by binding to excess IL-23. This can help reduce the inflammation inside the body that leads to plaques on the skin.

This medication is available in an injectable form to be given directly into the skin (subcutaneously).

Common side effects include upper respiratory infections, headache and tiredness. 

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Uses of Skyrizi

Skyrizi is a prescription medicine used to treat adults with moderate to severe plaque psoriasis who may benefit from taking injections or pills (systemic therapy) or treatment using ultraviolet or UV light (phototherapy).

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.


For more information on this medication choose from the list of selections below.

Skyrizi Drug Class

Skyrizi is part of the drug class:

Side Effects of Skyrizi

Serious side effects have been reported with Skyrizi. See the "Skyrizi Precautions" section.

Common side effects of Skyrizi include the following:

  • upper respiratory infections (cold-like symptoms)
  • headache
  • tiredness
  • injection-site reactions (redness, skin irritation)
  • tinea infections (skin rashes caused by fungi)

This is not a complete list of Skyrizi side effects. Ask your doctor or pharmacist for more information.

Tell your doctor if you have any side effect that bothers you or does not go away.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Skyrizi Interactions

No drug interactions have been studied by the manufacturer. However, you should tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Not all drug interactions are known or reported and new drug interactions are continually being reported.

Additionally, tell your doctor if you are scheduled to take any vaccines or have recently received a vaccine.

Skyrizi Precautions

Serious side effects have been reported with Skyrizi including the following:

  • Infections. Skyrizi may lower the ability of your immune system to fight infections and may increase your risk of infections. Your healthcare provider should check you for infections and tuberculosis (TB) before starting treatment with Skyrizi and may treat you for TB before you begin treatment with Skyrizi if you have a history of TB or have active TB. Your healthcare provider should watch you closely for signs and symptoms of TB during and after treatment with Skyrizi. Tell your healthcare provider right away if you have an infection or have symptoms of an infection, including:
  • fever, sweats, or chills
  • cough
  • shortness of breath
  • blood in your mucus (phlegm)
  • muscle aches
  • warm, red, or painful skin or sores on your body different from your psoriasis
  • weight loss
  • diarrhea or stomach pain
  • burning when you urinate  or urinating more often than normal

Do not take Skyrizi if you are allergic to any of its ingredients.

Skyrizi Food Interactions

Medications can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of Skyrizi, there are no specific foods that you must exclude from your diet when receiving this medication.

Inform MD

Before taking Skyrizi, tell your doctor about all of your medical conditions. Especially tell your doctor if you:

  • are allergic to any of its ingredients
  • have an active infection or suspect you may have an infection
  • have ever had TB (tuberculosis) or been in contact with someone with TB
  • have recently received or are scheduled to receive a vaccination
  • are pregnant or plan to become pregnant
  • are breastfeeding or plan to breastfeed

Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements.

Skyrizi and Pregnancy

Tell your doctor if you are pregnant or plan to become pregnant.

There are no well-done studies that have been done in humans with Skyrizi. In animal studies, pregnant animals were given this medication and the babies did not show any medical issues related to this medication. However, the animals did have an increased number of miscarriages. Therefore, this medication may be used if the potential benefits to the mother outweigh the potential risks to the unborn child.

Skyrizi and Lactation

Tell your doctor if you are breastfeeding or plan to breastfeed.

It is not known if Skyrizi crosses into human milk. Because many medications can cross into human milk and because the possibility for serious adverse reactions in nursing infants with use of this medication, a choice should be made whether to stop nursing or stop the use of this medication. Your doctor and you will decide if the benefits outweigh the risk of using Skyrizi.

Skyrizi Usage

Take Skyrizi exactly as prescribed. 

See the detailed “Instructions for Use” that comes with Skyrizi for information on how to prepare and inject a dose of Skyrizi, and how to properly throw away (dispose of) used Skyrizi prefilled syringes.

This medication is available in an injectable form to be given directly into the skin (subcutaneously). 

If you miss a dose, take the missed dose as soon as you remember. If it is almost time for the next dose, skip the missed dose and take your next dose at the regular time. Do not take 2 doses of Skyrizi at the same time. 

Skyrizi Dosage

Take this medication exactly as prescibed by your doctor. Follow the directions on your prescription label carefully. 

The recommended dose is 150 mg (two 75 mg injections) administered by subcutaneous injection at Week 0, Week 4, and every 12 weeks thereafter.

Skyrizi Overdose

If you take too much Skyrizi, call your healthcare provider or local poison control center, or seek emergency medical attention right away.

Other Requirements

  • Store Skyrizi in the refrigerator between 36°F to 46°F (2°C to 8°C).
  • Do not freeze Skyrizi.
  • Do not shake Skyrizi.
  • Keep Skyrizi in the original carton to protect it from light.
  • Keep Skyrizi and all medicines out of the reach of children.