Roxybond is used to treat moderate to severe pain. Roxybond may cause constipation.

Roxybond Overview

Reviewed: May 4, 2017

Roxybond is a prescription medication used to treat moderate to severe pain. This medication belongs to a group of drugs called opioids which work by stopping pain signals in the brain.

Roxybond comes in tablet form and can be taken every 4-6 hours scheduled or as needed for pain. Roxybond can cause upset stomach, but taking it with food can help. 

Common side effects of Roxybond include constipation, nausea, drowsiness, and dizziness. Do not drive or operate heavy machinery until you know how Roxybond affects you. 

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Roxybond Cautionary Labels


Uses of Roxybond

Roxybond is a prescription medication used to treat moderate to severe pain when other analgesic medications, such as ibuprofen (Advil) or acetaminophen (Tylenol), fail to treat the pain. 

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

Roxybond Drug Class

Roxybond is part of the drug class:

Side Effects of Roxybond

Serious side effects have been reported with Roxybond. See the "Roxybond Precautions" section. 

Common side effects of Roxybond include the following:

  • nausea
  • constipation
  • vomiting
  • headache
  • itching
  • insomnia
  • dizziness

This is not a complete list of Roxybond side effects. Ask your doctor or pharmacist for more information. Tell your doctor if you have side effects that bother you or that do not go away. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Roxybond Interactions

Tell your healthcare provider about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you take:

  • inhibitors of CYP3A4
    • clarithromycin (Biaxin), indinavir, ritonavir (Norvir), boceprevir (Victrelis), ketoconazole (Nizoral, Extina), itraconazole (Sporanox), posaconazole (Noxafil), nefazodone (Serzone)
  • inducers of CYP3A4
  • CNS depressants
    • barbiturate medications including
      • butalbital, pentobarbital (Nembutal), phenobarbital (Luminal)
    • benzodiazepine medications including
      • clonazepam (Klonopin), diazepam (Diastat), lorazepam (Ativan), midazolam (Versed), alprazolam (Xanax), temazepam (Restoril)
    • hypnotic medications including
      • eszopiclone (Lunesta), zeleplon (Sonata), zolpidem (Ambien)
    • first generation antihistamine medications including
      • diphenhydramine (Benedryl), doxylamine (Diclectin), promethazine (Phenergan), hydroxyzine (Vistaril), chlorpheniramine (Chlor-Trimeton)
    • muscle relaxant medications including
      • baclofen (Lioresal), carisoprodol (Somadril), cyclobenzaprine (Flexeril), methocarbamol (Robaxin), tizanidine (Zanaflex), gabapentin (Neurontin), pregabalin (Lyrica)
    • opioid pain relieving medications including
    • antidepressant medications including
    • antipsychotic medications including
      • olanzapine (Zyprexa), clozapine (Clozaril), haloperidol (Haldol), fluphenazine (Prolixin), quetiapine (Seroquel), prochlorperazine (Compazine)
  • serotonergic drugs
    • citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem), nefazodone (Serzone), trimipramine (Surmontil), nortriptyline (Pamelor, Aventyl), linezolid (Zyvox)
  • MAOI
    • isocarboxazid (Marplan), phenelzine (Nardil), tranylcypromine (Parnate), selegiline (Emsam, Eldepryl, Zelapar), rasagiline (Azilect)
  • mixed agonist/antagonist
  • muscle relaxants
    • carisoprodol (Soma), chlorzoxazone (Parafon, Lorzone), cyclobenzaprine (Fexmid, Flexeril, Amrix), metaxalone (Skelaxin, Metaxall), methocarbamol (Robaxin), tizanidine (Zanaflex)
  • diuretics
    • acetazolamide (Diamox), amiloride (Midamor), bumetanide (Bumex), chlorothiazide (Diuril), chlorothiazide (Thalitone), furosemide (Lasix), hydrochlorothiazide (Microzide, HCTZ), metolazone (Zaroxolyn, torsemide (Demadex), triamterene (Dyrenium, Dyazide, Maxzide)
  • anticholinergics
    • glycopyrrolate (Cuvposa, Robinul), trospium (Sanctura), oxybutynin (Anturol, Gelnique, Oxytrol, Ditropan), solifenacin (Vesicare), dicyclomine (Bentyl), propantheline (Pro-Banthine), atropine (Atropen, Sal-Tropine)

This is not a complete list of Roxybond drug interactions. Ask your doctor or pharmacist for more information. 

Roxybond Precautions

Serious side effects have been reported with Roxybond including the following:

Addiction, Abuse, Misuse. There is a chance of abuse or addiction with Roxybond. The chance is higher if you are or have been addicted to or abused other medicines, street drugs, or alcohol, or if you have a history of mental problems.

Serious breathing problems (Respiratory Depression). Roxybond can cause serious breathing problems that can become life-threatening, especially in patients with chronic lung disease, elderly patients, or disabled patients. Increased risk if Roxybond is used the wrong way. Call your healthcare provider right away if:

  • your breathing slows down
  • you have shallow breathing (little chest movement with breathing)
  • you feel faint, dizzy, confused, or
  • you have any other unusual symptoms

Opioid Withdrawal Syndrome in Infants. Roxybond can cause harm, potentially death, to the baby if administered to pregnant women.

Adrenal Insufficiency (adrenal glands don't make enough of these hormones). Adrenal insufficiency is confirmed, your doctor will give you steroids and slowly decrease you Roxybond dose.

Severe Low Blood Pressure. Roxybond can cause your blood pressure to drop. This can make you feel dizzy and faint if you get up too fast from sitting or lying down. Low blood pressure is also more likely to happen if you take other medicines that can also lower your blood pressure. Severe low blood pressure can happen if you lost blood or take certain other medicines.

Risk of Use in Patients with Increased Intracranial Pressure. Patients with brain tumors, head injury, coma, or impaired consciousness are at an increased risk of sedation or respiratory problems while taking Roxybond.

Risk of Use in Patients with Seizure Disorders. Roxybond can increase the frequency of seizures. 

Withdrawals. Do not stop Roxybond without first talking to your healthcare provider. Stopping Roxybond suddenly may cause serious symptoms including:

  • anxiety
  • sweating
  • insomnia
  • shaking/shivering
  • pain
  • nausea
  • diarrhea
  • upper airway symptoms
  • goosebumps

Roxybond can make you sleepy. Do not drive, operate heavy machinery, or participate in any other possibly dangerous activities until you know how you react to this medication. 

Do not drink alcohol or use prescription or over-the-counter medicines that contain alcohol while taking Roxybond. Drinking alcohol with Roxybond may cause you to overdose and die.

Do not take Roxybond if you:

  • are allergic to Roxybond or any of its ingredients
  • have an obstruction in the stomach or intestines
  • have significant respiratory depression
  • have acute or severe bronchial asthma

Roxybond Food Interactions

Medications can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In some cases of Roxybond, there are no specific foods that you must exclude from your diet when receiving this medication. 

Inform MD

Before taking Roxybond, tell your doctor about all of your medical conditions. Especially tell your doctor if you

  • are allergic to Roxybond or any of its ingredients
  • are pregnant or plan to become pregnant
  • are breastfeeding or plan to breastfeed
  • have or have had a GI blockage
  • have a seizure disorder
  • have an enlarged prostate or problems urinating

Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements.

Roxybond and Pregnancy

Tell your doctor if you are pregnant or plan to become pregnant. 

It has been shown that the use of Roxybond in pregnant women caused some babies to be born with problems. Therefore, this medication should be used during pregnancy only if the benefit outweighs the possible risk to the unborn baby. 

Roxybond and Lactation

Tell your doctor if you are breastfeeding or plan to breastfeed.

Roxybond has been detected in human breast milk. Because of the possibility for adverse reactions in nursing infants, a choice should be made whether to stop nursing or to stop Roxybond. The importance of the drug to the mother should be considered.

Roxybond Usage

Take Roxybond exactly as prescribed. 

Roxybond comes in tablet form and can be taken every 4-6 hours scheduled or as needed for pain. Roxybond can be taken for a max of 6 times a day depending on the severity of the pain. Roxybond may cause stomach upset. Taking it with food may help.

If you miss a dose, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once unless your doctor tells you to.

Roxybond Dosage

Take Roxybond exactly as prescribed by your doctor. Follow the directions on your prescription label carefully. Your doctor will determine the best dose for you. The dosage of Roxybond must be individualized.

Roxybond Overdose

If you take too much Roxybond, call your healthcare provider or local Poison Control Center, or seek emergency medical attention right away. 

Other Requirements

  • Keep Roxybond out of the reach of children. Accidental overdose by a child is dangerous and can lead to death.
  • Store Roxybond at room temperature.
  • Keep Roxybond in the container it comes in.
  • Keep the container tightly closed and away from light.

Roxybond is a federally controlled substance (CII) because it can be abused or lead to dependence. Keep this medication in a safe place to prevent misuse and abuse. Selling or giving away Roxybond may harm others, and is against the law.

Roxybond FDA Warning


  • Roxybond increases the risk of addiction, abuse, and misuse which can lead to overdose and death. Consistent monitoring is required before and during Roxybond use.
  • Serious, life-threatening, or fatal respiratory depression may occur. Monitor closely, especially upon initiation or following a dose increase.
  • Ingestion of Roxybond by children, can result in a fatal overdose of oxycodone.
  • Prolonged use of Roxybond during pregnancy can result in fetal opioid withdrawal syndrome, and can be life-threatening. If use is required in a pregnant woman, educate on the risk of neonatal opioid withdrawal syndrome and ensure that appropriate treatment will be available.
  • Concomitant use with CYP3A4 inhibitors (or discontinuation of CYP3A4 inducers) can result in a fatal overdose of Roxybond. 
  • Concomitant use of opioids with central nervous system (CNS) depressants, including alcohol, may result in profound sedation, respiratory depression, coma, and death.