Opana treats moderate to severe pain. Do not drink alcohol while taking this medication.

Opana Overview

Reviewed: November 20, 2014

Opana is a prescription medication used to treat moderate to severe pain. 

Opana belongs to a group of drugs called called opiate (narcotic) analgesics. These work by changing the way the body responds to pain.

Opana is available in a tablet form and is usually given every four to six hours. It will depend on how intense your pain is. 

Opana tablets should be taken on an empty stomach, at least 1 hour before or 2 hours after meals. 

Opana is also available in an injectable form to be given directly into a vein (IV), in the muscle (IM), and under your skin (subcutaneously) by a healthcare professional.

Common side effects include constipation, nausea, and vomiting.

Opana can also cause drowsiness and dizziness. Do not drive or operate heavy machinery until you know how Opana affects you.

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Opana Cautionary Labels


Uses of Opana

Opana is a prescription medication used to relieve moderate to severe pain for those who need pain medication around the clock.

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.



For more information on this medication choose from the list of selections below.

Opana Drug Class

Opana is part of the drug class:

Side Effects of Opana

Serious side effects have been reported with Opana. See the “Opana Precautions” section.

Common side effects of Opana tablets include the following:

  • constipation
  • nausea
  • vomiting
  • tiredness
  • headache
  • stomach pain
  • drowsiness
  • dizziness
  • increased sweating
  • dry mouth
  • diarrhea
  • insomnia  (difficulty falling asleep or staying asleep)
  • fatigue (tired)
  • decreased appetite
  • itching

Common side effects of Opana injection include the following:

  • blurred vision
  • fast heart rate
  • nausea
  • vomiting
  • constipation
  • fatigue (tired)
  • euphoric mood (feeling high)
  • rash
  • low blood pressure
  • flushing
  • itching

This is not a complete list of Opana side effects. Ask your doctor or pharmacist for more information.

Tell your doctor if you have any side effect that bothers you or that does not go away.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.