A Study of Palbociclib (PD-0332991) + Letrozole vs. Letrozole For 1st Line Treatment Of Postmenopausal Women With ER+/HER2- Advanced Breast Cancer (PALOMA-2)
Overview[ - collapse ][ - ]
| Purpose | The study is designed to compare the clinical benefit following treatment with letrozole in combination with PD-0332991 versus letrozole in combination with placebo in postmenopausal women with ER(+)/HER2(-) advanced breast cancer who have not received prior systemic anti cancer therapies for their advanced/metastatic disease. | 
|---|---|
| Condition | Breast Neoplasms | 
| Intervention | Drug: PD-0332991 Drug: Letrozole Drug: Placebo Drug: Letrozole | 
| Phase | Phase 3 | 
| Sponsor | Pfizer | 
| Responsible Party | Pfizer | 
| ClinicalTrials.gov Identifier | NCT01740427 | 
| First Received | November 26, 2012 | 
| Last Updated | April 24, 2014 | 
| Last verified | April 2014 | 
Tracking Information[ + expand ][ + ]
| First Received Date | November 26, 2012 | 
|---|---|
| Last Updated Date | April 24, 2014 | 
| Start Date | February 2013 | 
| Estimated Primary Completion Date | March 2016 | 
| Current Primary Outcome Measures | Progression-Free Survival (PFS) [Time Frame: Baseline up to 2.5 years] [Designated as safety issue: No]Median time from the first dose of study treatment to the first documentation of objective tumor progression or to death due to any cause, whichever occurs first. | 
| Current Secondary Outcome Measures | 
 | 
Descriptive Information[ + expand ][ + ]
| Brief Title | A Study of Palbociclib (PD-0332991) + Letrozole vs. Letrozole For 1st Line Treatment Of Postmenopausal Women With ER+/HER2- Advanced Breast Cancer (PALOMA-2) | 
|---|---|
| Official Title | A Randomized, Multicenter, Double-Blind Phase 3 Study Of PD-0332991 (Oral CDK 4/6 Inhibitor) Plus Letrozole Versus Placebo Plus Letrozole For The Treatment Of Postmenopausal Women With ER (+), HER2 (-) Breast Cancer Who Have Not Received Any Prior Systemic Anti Cancer Treatment For Advanced Disease | 
| Brief Summary | The study is designed to compare the clinical benefit following treatment with letrozole in combination with PD-0332991 versus letrozole in combination with placebo in postmenopausal women with ER(+)/HER2(-) advanced breast cancer who have not received prior systemic anti cancer therapies for their advanced/metastatic disease. | 
| Detailed Description | Not Provided | 
| Study Type | Interventional | 
| Study Phase | Phase 3 | 
| Study Design | Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment | 
| Condition | Breast Neoplasms | 
| Intervention | Drug: PD-0332991 PD-0332991, 125mg, orally once daily on Day 1 to Day 21 of every 28-day cycle followed by 7 days off treatment Drug: Letrozole Letrozole, 2.5mg, orally once daily (continuously) Drug: Placebo Placebo, 125mg, orally once daily on Day 1 to Day 21 of every 28-day cycle followed by 7 days off treatment Drug: Letrozole Letrozole, 2.5mg, orally once daily (continuously) | 
| Study Arm (s) | 
 | 
Recruitment Information[ + expand ][ + ]
| Recruitment Status | Recruiting | 
|---|---|
| Estimated Enrollment | 450 | 
| Estimated Completion Date | March 2016 | 
| Estimated Primary Completion Date | March 2015 | 
| Eligibility Criteria | Inclusion Criteria: - Adult women with locoregionally recurrent or metastatic disease not amenable to curative therapy. - Confirmed diagnosis of ER positive breast cancer - No prior systemic anti-cancer therapy for advanced ER+ disease. - Postmenopausal women - Measurable disease as per Response Evaluation Criterion in Solid Tumors [RECIST] or bone-only disease - Eastern Cooperative Oncology Group [ECOG] 0-2 - Adequate organ and marrow function - Patient must agree to provide tumor tissue Exclusion Criteria: - Confirmed diagnosis of HER2 positive disease - Patients with advanced, symptomatic, visceral spread that are at risk of life threatening complication in the short term - Known uncontrolled or symptomatic CNS metastases - Prior (neo)adjuvant treatment with letrozole or anastrozole with DFI ≤ 12-months from completion of treatment. - Prior treatment with any CDK 4/6 inhibitor. | 
| Gender | Female | 
| Ages | 18 Years | 
| Accepts Healthy Volunteers | No | 
| Contacts | Contact: Pfizer CT.gov Call Center 1-800-718-1021 | 
| Location Countries | United States, Australia, Belgium, Canada, Czech Republic, France, Germany, Hungary, Ireland, Italy, Japan, Korea, Republic of, New Zealand, Poland, Russian Federation, Spain, Taiwan, Ukraine, United Kingdom | 
Administrative Information[ + expand ][ + ]
| NCT Number | NCT01740427 | 
|---|---|
| Other Study ID Numbers | A5481008 | 
| Has Data Monitoring Committee | Yes | 
| Information Provided By | Pfizer | 
| Study Sponsor | Pfizer | 
| Collaborators | Not Provided | 
| Investigators | Study Director: Pfizer CT.gov Call Center Pfizer | 
| Verification Date | April 2014 | 
Locations[ + expand ][ + ]
| UCLA Hematology Oncology | Alhambra, California, United States, 91801Contact: Audrey Roque-Tayag | ARTayag@mednet.ucla.edu Recruiting | 
|---|---|
| Kaiser Permanente - Anaheim | Anaheim, California, United States, 92806 Active, not recruiting | 
| Kaiser Permanente Baldwin Park Medical Offices | Baldwin Park, California, United States, 91706 Active, not recruiting | 
| Southern California Kaiser Medical Center - Bellflower Medical Offices | Bellflower, California, United States, 90706 Active, not recruiting | 
| Beverly Hills Cancer Center | Beverly Hills, California, United States, 90211Contact: Roxanne Mendez | 310-432-8931 | rmendez@bhcancercenter.com Recruiting | 
| Kaiser Foundation Hospital | Fontana, California, United States, 92335 Active, not recruiting | 
| St. Jude Heritage Healthcare - Virginia K. Crosson Cancer Center | Fullerton, California, United States, 92835Contact: Gayle Madden-Mathes | 714-446-5900 | gmadden@mednet.ucla.edu Recruiting | 
| Kaiser Permanente | Harbor City, California, United States, 90710 Active, not recruiting | 
| UCLA/TRIO US Network | Irvine, California, United States, 92604Contact: Audrey Roque-Tayag | ARTayag@mednet.ucla.edu Recruiting | 
| Kaiser Permanente Irvine Medical Offices | Irvine, California, United States, 92618 Active, not recruiting | 
| UCLA West Medical Pharmacy | Los Angeles, California, United States, 90095-1772Contact: Alison Fernandez | 805-739-3724 | alison.fernandez@dignityhealth.org Recruiting | 
| UCLA School of Medicine | Los Angeles, California, United States, 90095Contact: Audrey Roque-Tayag | ARTayag@mednet.ucla.edu Recruiting | 
| TRIO-US Central Administration | Los Angeles, California, United States, 90095Contact: Erikan I Enyong | 805-543-5577 | eenyong@ohmacc.com Recruiting | 
| UCLA West Medical Pharmacy | Los Angeles, California, United States, 90095-1772Contact: Laci Wilkins | 970-298-7125 | laci.wilkins@sclhs.net Recruiting | 
| Kaiser Permanente | Los Angeles, California, United States, 90027 Active, not recruiting | 
| TRIO-US Central Administration | Los Angeles, California, United States, 90095Contact: Laci Wilkins | 970-298-7125 | laci.wilkins@sclhs.net Recruiting | 
| TRIO-US Central Administration | Los Angeles, California, United States, 90095Contact: Sherry Hutcherson | 310-750-3300 | shutcherson@mednet.ucla.edu Recruiting | 
| TRIO-US Central Administration | Los Angeles, California, United States, 90095Contact: Gayle Madden-Mathes | 714-446-5900 | gmadden@mednet.ucla.edu Recruiting | 
| Kaiser Permanente Hospital | Los Angeles, California, United States, 90034 Active, not recruiting | 
| TRIO-US Central Administration | Los Angeles, California, United States, 90095Contact: Alisa Penrod | alisa.penrod@CSNF.US Recruiting | 
| UCLA West Medical Pharmacy | Los Angeles, California, United States, 90095-1772Contact: Jowanna Kerr | 678-312-3835 | jkerr@gwinnettmedicalcenter.org Recruiting | 
| UCLA West Medical Pharmacy | Los Angeles, California, United States, 90095-1772Contact: Erikan I Enyong | 805-543-5577 | eenyong@ohmacc.com Recruiting | 
| UCLA Hematology Oncology | Los Angeles, California, United States, 90095Contact: Audrey Roque-Tayag | ARTayag@mednet.ucla.edu Recruiting | 
| Ronald Reagan UCLA Medical Center | Los Angeles, California, United States, 90095Contact: Audrey Roque-Tayag | ARTayag@mednet.ucla.edu Recruiting | 
| TRIO-US Central Administration | Los Angeles, California, United States, 90095Contact: Alison Fernandez | 805-739-3724 | alison.fernandez@dignityhealth.org Recruiting | 
| UCLA West Medical Pharmacy | Los Angeles, California, United States, 90095-7349Contact: Sherry Hutcherson | 310-750-3300 | shutcherson@mednet.ucla.edu Recruiting | 
| UCLA West Medical Pharmacy | Los Angeles, California, United States, 90095-1772Contact: Alisa Penrod | alisa.penrod@CSNF.US Recruiting | 
| Westwood Bowyer Clinic | Los Angeles, California, United States, 90095Contact: Audrey Roque-Tayag | ARTayag@mednet.ucla.edu Recruiting | 
| UCLA West Medical Pharmacy | Los Angeles, California, United States, 90095-1772Contact: Sue Yates | 702-384-0013 | sue.yates@usoncology.com Recruiting | 
| Los Angeles Hematology/Oncology Medical Group | Los Angeles, California, United States, 90017Contact: Kim Long | 626-204-7893 | klong@healthcarepartners.com Recruiting | 
| TRIO-US Central Administration | Los Angeles, California, United States, 90095Contact: Jowanna Kerr | 678-312-3835 | jkerr@gwinnettmedicalcenter.org Recruiting | 
| TRIO-US Central Administration | Los Angeles, California, United States, 90095Contact: Jayme Ion | 954-265-2615 | jion@mhs.net Recruiting | 
| Keck School of Medicine, University of Southern California | Los Angeles, California, United States, 90033 Not yet recruiting | 
| UCLA West Medical Pharmacy, Attn: Steven L. Wong | Los Angeles, California, United States, 90095-7349Contact: Gayle Madden-Mathes | 714-446-5900 | gmadden@mednet.ucla.edu Recruiting | 
| UCLA West Medical Pharmacy | Los Angeles, California, United States, 90095-1772Contact: Jayme Ion | 954-265-2615 | jion@mhs.net Recruiting | 
| TRIO-US Central Administration | Los Angeles, California, United States, 90095Contact: Sue Yates | 702-384-0013 | sue.yates@usoncology.com Recruiting | 
| Kaiser Permanente | Panorama City, California, United States, 91402 Active, not recruiting | 
| UCLA/Pasadena HealthCare | Pasadena, California, United States, 91105Contact: Audrey Roque-Tayag | ARTayag@mednet.ucla.edu Recruiting | 
| UCLA Hematology Oncology-Porter Ranch | Porter Ranch, California, United States, 91326Contact: Audrey Roque-Tayag | ARTayag@mednet.ucla.edu Recruiting | 
| Cancer Care Associates Medical Group, Inc. | Redondo Beach, California, United States, 90277Contact: Sherry Hutcherson | 310-750-3300 | shutcherson@mednet.ucla.edu Recruiting | 
| Kaiser Permanente Riverside Medical Offices | Riverside, California, United States, 92505 Active, not recruiting | 
| Kaiser Permanente Medical Center | San Diego, California, United States, 92120 Active, not recruiting | 
| University of California, San Francisco | San Francisco, California, United States, 94115Contact: Courtney Grosvenor | GrosvenorC@cc.ucsf.edu Recruiting | 
| Coastal Integrative Cancer Care | San Luis Obispo, California, United States, 93401Contact: Erikan I Enyong | 805-543-5577 | eenyong@ohmacc.com Recruiting | 
| Kaiser Permanente | San Marcos, California, United States, 92069 Active, not recruiting | 
| Central Coast Medical Oncology Corporation | Santa Maria, California, United States, 93454Contact: Alison Fernandez | 805-739-3724 | alison.fernandez@dignityhealth.org Recruiting | 
| UCLA Hematology Oncology - Santa Monica | Santa Monica, California, United States, 90404Contact: Audrey Roque-Tayag | ARTayag@mednet.ucla.edu Recruiting | 
| UCLA Santa Monica Medical Center and Orthopaedic Hospital | Santa Monica, California, United States, 90404Contact: Audrey Roque-Tayag | ARTayag@mednet.ucla.edu Recruiting | 
| UCLA Hematology Oncology Santa Monica | Santa Monica, California, United States, 90404Contact: Audrey Roque-Tayag | ARTayag@mednet.ucla.edu Recruiting | 
| Stanford School of Medicine | Stanford, California, United States, 94305Contact: Karen Lau | 650-723-0658 | kkwlau@stanford.edu Recruiting | 
| UCLA/Santa Clarita Valley Cancer Center | Valencia, California, United States, 91355Contact: Audrey Roque-Tayag | ARTayag@mednet.ucla.edu Recruiting | 
| UCLA Cancer Center | Westlake Village, California, United States, 91361Contact: Audrey Roque-Tayag | ARTayag@mednet.ucla.edu Recruiting | 
| Kaiser Permanente Woodland Hills Medical Offices | Woodland Hills, California, United States, 91365 Active, not recruiting | 
| St. Mary's Hospital Regional Cancer Center | Grand Junction, Colorado, United States, 81501Contact: Laci Wilkins | 970-298-7125 | laci.wilkins@sclhs.net Recruiting | 
| Yale University School of Medicine | New Haven, Connecticut, United States, 06510Contact: Rebecca Lilian | 203-737-2226 | rebecca.lilian@yale.edu Recruiting | 
| Smilow Cancer Center at Yale New Haven | New Haven, Connecticut, United States, 06510Contact: Rebecca Lilian | 203-737-2226 | rebecca.lilian@yale.edu Recruiting | 
| Whittingham Cancer Center @ Norwalk Hospital | Norwalk, Connecticut, United States, 06856Contact: Rita L Ort | 203-852-3063 | rita.ort@norwalkhealth.org Recruiting | 
| Washington Cancer Institute at MedStar Washington Hospital Center | Washington, District of Columbia, United States, 20010Contact: Nellie Novielle | noviella@georgetown.edu Recruiting | 
| Lombardi Comprehensive Cancer Center - Podium A | Washington, District of Columbia, United States, 20007-2197Contact: Nellie Novielle | noviella@georgetown.edu Recruiting | 
| University of Miami | Deerfield, Florida, United States, 33442Contact: Olga M Aguero | 305-243-9811 | omachado1@med.miami.edu Recruiting | 
| Cancer Specialist of North Florida/Fleming Island | Fleming Island, Florida, United States, 32003Contact: Alisa Penrod | alisa.penrod@CSNF.US Recruiting | 
| Michael & Dianne Bienes Cancer Center | Fort Lauderdale, Florida, United States, 33308Contact: Eileen Georgi | 954-267-7700 | Eileen.Georgi@holy-cross.com Not yet recruiting | 
| Memorial Cancer Institute East | Hollywood, Florida, United States, 33021Contact: Jayme Ion | 954-265-2615 | jion@mhs.net Recruiting | 
| Memorial Regional Hospital | Hollywood, Florida, United States, 33021Contact: Jayme Ion | 954-265-2615 | jion@mhs.net Recruiting | 
| Memorial Cancer Institute/Breast Cancer Center | Hollywood, Florida, United States, 33021Contact: Jayme Ion | 954-265-2615 | jion@mhs.net Recruiting | 
| Cancer Specialist of North Florida/Baptist Medical Center- South | Jacksonville, Florida, United States, 32258Contact: Alisa Penrod | alisa.penrod@CSNF.US Recruiting | 
| Cancer Specialist of North Florida/Baptist Medical Center- downtown | Jacksonville, Florida, United States, 32207Contact: Alisa Penrod | alisa.penrod@CSNF.US Recruiting | 
| Cancer Specialist of North Florida- Southside | Jacksonville, Florida, United States, 32258Contact: Alisa Penrod | alisa.penrod@CSNF.US Recruiting | 
| Cancer Specialist of North Florida/ St. Vincent's | Jacksonville, Florida, United States, 32204Contact: Alisa Penrod | alisa.penrod@CSNF.US Recruiting | 
| Cancer Specialist of North Florida | Jacksonville, Florida, United States, 32256Contact: Alisa Penrod | alisa.penrod@CSNF.US Recruiting | 
| University of Miami Hospital and Clinics | Miami, Florida, United States, 33136Contact: Olga M Aguero | 305-243-9811 | omachado1@med.miami.edu Recruiting | 
| Orlando Health, Inc. | Orlando, Florida, United States, 32806Contact: Tina Anderson | 321-841-2285 | tanderson@ocrc.et Recruiting | 
| Memorial Hospital WEST | Pembroke Pines, Florida, United States, 33028Contact: Jayme Ion | 954-265-2615 | jion@mhs.net Recruiting | 
| Memorial Cancer Institute West | Pembroke Pines, Florida, United States, 33028Contact: Jayme Ion | 954-265-2615 | jion@mhs.net Recruiting | 
| Memorial Cancer Institute | Pembroke Pines, Florida, United States, 33028Contact: Jayme Ion | 954-265-2615 | jion@mhs.net Recruiting | 
| University of Miami | Plantation, Florida, United States, 33324Contact: Olga M Aguero | 305-243-9811 | omachado1@med.miami.edu Recruiting | 
| Cancer Specialist of North Florida/St. Augustine | St. Augustine, Florida, United States, 32086Contact: Alisa Penrod | alisa.penrod@CSNF.US Recruiting | 
| Northeast Georgia Cancer Care, LLC | Athens, Georgia, United States, 30607Contact: Jamie M Hodgson | 706-353-2990279 | jhodgson@negacancer.com Not yet recruiting | 
| Emory University Hospital Midtown | Atlanta, Georgia, United States, 30308Contact: Stephanie McMillan | 404-778-4326 | sjmcmil@emory.edu Recruiting | 
| Emory Clinic | Atlanta, Georgia, United States, 30322Contact: Stephanie McMillan | 404-778-4326 | sjmcmil@emory.edu Recruiting | 
| Emory University Hospital | Atlanta, Georgia, United States, 30322Contact: Stephanie McMillan | 404-778-4326 | sjmcmil@emory.edu Recruiting | 
| Grady Health System | Atlanta, Georgia, United States, 30303Contact: Stephanie McMillan | 404-778-4326 | sjmcmil@emory.edu Recruiting | 
| Winship Cancer Institute, Emory University School of Medicine | Atlanta, Georgia, United States, 30322Contact: Stephanie McMillan | 404-778-4326 | sjmcmil@emory.edu Recruiting | 
| Gwinnett Hospital System Inc.-d/b/a-The Center for Cancer Care | Duluth, Georgia, United States, 30096Contact: Jowanna Kerr | 678-312-3835 | jkerr@gwinnettmedicalcenter.org Recruiting | 
| Gwinnett Hospital System Inc. -d/b/a-The Center for Cancer Care | Lawrenceville, Georgia, United States, 30046Contact: Jowanna Kerr | 678-312-3835 | jkerr@gwinnettmedicalcenter.org Recruiting | 
| Gwinnett Hospital System Inc.-d/b/a-The Center for Cancer Care | Lawrenceville, Georgia, United States, 30046Contact: Jowanna Kerr | 678-312-3835 | jkerr@gwinnettmedicalcenter.org Recruiting | 
| Northwest Georgia Oncology Centers, PC | Marietta, Georgia, United States, 30060Contact: Mary Gilley | 770-281-5131 | mgilley@ngoc.com Recruiting | 
| Gwinnett Hospital System Inc.-d/b/a-The Center for Cancer Care | Snellville, Georgia, United States, 30078Contact: Jowanna Kerr | 678-312-3835 | jkerr@gwinnettmedicalcenter.org Recruiting | 
| Kootenai Cancer Center | Coeur d'Alene, Idaho, United States, 83814Contact: Robin Gustin | 208-666-3800 | rgustin@niccresearch.org Recruiting | 
| Carle Foundation Hospital DBA Carle Cancer Center | Danville, Illinois, United States, 61832Contact: Christine Canfield | 217-383-3010 | christine.canfield@carle.com Recruiting | 
| Carle Foundation Hospital DBA Carle Cancer Center | Effingham, Illinois, United States, 62401Contact: Christine Canfield | 217-383-3010 | christine.canfield@carle.com Recruiting | 
| Carle Foundation Hospital DBA Carle Cancer Center | Mattoon, Illinois, United States, 61938Contact: Christine Canfield | 217-383-3010 | christine.canfield@carle.com Recruiting | 
| Orchard Healthcare Research Inc. | Skokie, Illinois, United States, 60076Contact: Joy Jardinico | 847-731-4143 | joy.jardinico@ctca-hope.com Recruiting | 
| Carle Foundation Hospital DBA Carle Cancer Center | Urbana, Illinois, United States, 61801Contact: Christine Canfield | 217-383-3010 | christine.canfield@carle.com Recruiting | 
| JG Brown Cancer Center | Louisville, Kentucky, United States, 40202Contact: Belma KAntardzic | 502-594-5349 | bnkant01@louisville.edu Recruiting | 
| Harry and Jeanette Weinberg Cancer Institute at Franklin Square | Baltimore, Maryland, United States, 21237-3998Contact: Nellie Novielle | noviella@georgetown.edu Recruiting | 
| University of Maryland | Baltimore, Maryland, United States, 21201Contact: Jane Lewis | 410-328-7609 | jlewis@umm.edu Not yet recruiting | 
| Walter Reed National Military Medical Center | Bethesda, Maryland, United States, 20889-5600Contact: Joanna Shay | 301-400-0056 | joanna.l.shay.ctr@health.mil Recruiting | 
| University of Michigan Health System | Ann Arbor, Michigan, United States, 48100Contact: Deborah K Anderson | 734-763-5437 | debcarl@med.umich.edu Recruiting | 
| U of M Internal Medicine Oncology | Ann Arbor, Michigan, United States, 48109Contact: Deborah K Anderson | 734-763-5437 | debcarl@med.umich.edu Recruiting | 
| Sparrow Regional Cancer Center | Lansing, Michigan, United States, 48912Contact: Siamak Hejabian | 517-364-2467 | Siamak.Hejabian@sparrow.org Not yet recruiting | 
| Park Nicollet Frauenshuh Cancer Center | St. Louis Park, Minnesota, United States, 55426Contact: Alissa Gavenda | 952-993-6705 | Alissa.gavenda@parknicollet.com Recruiting | 
| The West Clinic | Corinth, Mississippi, United States, 38834Contact: Cindy Inman | 901-260-9276 | cinman@sosacorn.com Recruiting | 
| The West Clinic | Southaven, Mississippi, United States, 38671Contact: Cindy Inman | 901-260-9276 | cinman@sosacorn.com Recruiting | 
| Mercy Clinic St. Louis Cancer and Breast Institute | Ballwin, Missouri, United States, 63011Contact: Samia Das | 636-256-5294 | Samia.Das@Mercy.Net Recruiting | 
| Mercy Hospital St. Louis | St. Louis, Missouri, United States, 63141Contact: Samia Das | 636-256-5294 | Samia.Das@Mercy.Net Recruiting | 
| Mercy Clinic St. Louis Cancer and Breast Institute | St. Louis, Missouri, United States, 63109Contact: Samia Das | 636-256-5294 | Samia.Das@Mercy.Net Recruiting | 
| St. John's Mercy, David C. Pratt Cancer Center | St. Louis, Missouri, United States, 63141Contact: Samia Das | 636-256-5294 | Samia.Das@Mercy.Net Recruiting | 
| Saint Francis Cancer Treatment Center | Grand Island, Nebraska, United States, 68803Contact: Rebecca Haydenfeld | 308-398-5450 | rhadenfeldt@sfmc-gi.org Recruiting | 
| Saint Francis Medical Center | Grand Island, Nebraska, United States, 68803Contact: Rebecca Haydenfeld | 308-398-5450 | rhadenfeldt@sfmc-gi.org Recruiting | 
| Saint Frances Medical Center | Hastings, Nebraska, United States, 68901Contact: Rebecca Haydenfeld | 308-398-5450 | rhadenfeldt@sfmc-gi.org Recruiting | 
| Comprehensive Cancer Centers of Nevada Research Department | Henderson, Nevada, United States, 89052Contact: Sue Yates | 702-384-0013 | sue.yates@usoncology.com Recruiting | 
| Comprehensive Cancer Centers of Nevada | Henderson, Nevada, United States, 89052Contact: Sue Yates | 702-384-0013 | sue.yates@usoncology.com Recruiting | 
| Comprehensive Cancer Centers of Nevada | Henderson, Nevada, United States, 89074Contact: Sue Yates | 702-384-0013 | sue.yates@usoncology.com Recruiting | 
| Comprehensive Cancer Centers of Nevada | Las Vegas, Nevada, United States, 89148Contact: Sue Yates | 702-384-0013 | sue.yates@usoncology.com Recruiting | 
| Comprehensive Cancer Centers of Nevada | Las Vegas, Nevada, United States, 89169Contact: Sue Yates | 702-384-0013 | sue.yates@usoncology.com Recruiting | 
| Comprehensive Cancer Centers of Nevada | Las Vegas, Nevada, United States, 89128Contact: Sue Yates | 702-384-0013 | sue.yates@usoncology.com Recruiting | 
| Mount Kisco Medical Group | Mount Kisco, New York, United States, 10549Contact: Ahn Phung | 914-666-1366 | aphung@nwhc.net Recruiting | 
| Northern Westchester Hospital | Mt Kisco, New York, United States, 10549Contact: Ahn Phung | 914-666-1366 | aphung@nwhc.net Recruiting | 
| Columbia University Medical Center | New York, New York, United States, 10032Contact: Man Chi Ngan | 212-304-5580 | mn2527@cumc.columbia.edu Recruiting | 
| Herbert Irving Comprehensive Cancer Center | New York, New York, United States, 10032Contact: Man Chi Ngan | 212-304-5580 | mn2527@cumc.columbia.edu Recruiting | 
| Stony Brook University Medical Center Cancer Center | Stony Brook, New York, United States, 11794-8446Contact: Michele McCauley | michele.mccauley@stonybrookmedicine.edu Recruiting | 
| Northwest Cancer Specialists, P.C. | Portland, Oregon, United States, 97227Contact: Margaret E Bigler | 503-231-2612 | margaret.bigler@usoncology.com Recruiting | 
| Northwest Cancer Specialists, PC | Portland, Oregon, United States, 97213Contact: Margaret E Bigler | 503-231-2612 | margaret.bigler@usoncology.com Recruiting | 
| Kaiser Permanente Northwest Region | Portland, Oregon, United States, 97227Contact: Marjorie Erwin | 503-331-6294 | marjorie.erwin@kpchr.org Recruiting | 
| Oregon Health and Science University | Portland, Oregon, United States, 97201-3098Contact: Bridget C Gilbert-Ghormley | 503-498-9736 | boylebr@ohsu.edu Recruiting | 
| Northwest Cancer Specialists, P.C. | Tualatin, Oregon, United States, 97062Contact: Margaret E Bigler | 503-231-2612 | margaret.bigler@usoncology.com Recruiting | 
| Medical University of South Carolina | Charleston, South Carolina, United States, 29425Contact: Sarah Daanen Recruiting | 
| The West Clinic | Memphis, Tennessee, United States, 38120Contact: Cindy Inman | 901-260-9276 | cinman@sosacorn.com Recruiting | 
| The West Clinic | Memphis, Tennessee, United States, 38104Contact: Cindy Inman | 901-260-9276 | cinman@sosacorn.com Recruiting | 
| The Sarah Cannon Cancer Center | Nashville, Tennessee, United States, 37203Contact: Julie Trundle | 615-329-7413 | Julie.Trundle@scresearch.net Recruiting | 
| Texas Oncology-Baylor Charles A. Sammons Cancer Center | Dallas, Texas, United States, 75246Contact: Jonathan Huntzinger | 214-370-1942 | Jonathan.huntzinger@usoncology.com Recruiting | 
| Texas Oncology, PA | Dallas, Texas, United States, 75231Contact: Amy Jordan | 214-346-3508 | amy.jordan@usoncology.com Recruiting | 
| El Paso Cancer Treatment Center | El Paso, Texas, United States, 79915Contact: Sylvia Corchado | 915-747-4878 | sylvia.corchado@usoncology.com Recruiting | 
| Texas Oncology-El Paso Cancer Treatment Center Joe Battle | El Paso, Texas, United States, 79939Contact: Sylvia Corchado | 915-747-4878 | sylvia.corchado@usoncology.com Recruiting | 
| Texas Oncology-El Paso Cancer Treatment Center Grandview | El Paso, Texas, United States, 79902Contact: Sylvia Corchado | 915-747-4878 | sylvia.corchado@usoncology.com Recruiting | 
| Investigational Products Center (IPC) | Fort Worth, Texas, United States, 76177Contact: Christine Canfield | 217-383-3010 | christine.canfield@carle.com Recruiting | 
| Investigational Products Center (IPC) | Fort Worth, Texas, United States, 76177Contact: Sylvia Corchado | 915-747-4878 | sylvia.corchado@usoncology.com Recruiting | 
| Investigational Products Center (IPC) | Fort Worth, Texas, United States, 76177Contact: Margaret E Bigler | 503-231-2612 | margaret.bigler@usoncology.com Recruiting | 
| Investigational Products Center (IPC) | Fort Worth, Texas, United States, 76177Contact: Kristy Lee | 972-867-3577 | kristy.lee@usoncology.com Not yet recruiting | 
| Investigational Products Center (IPC) | Fort Worth, Texas, United States, 76177Contact: Elaine Wilton | 757-262-4633 | elaine.wilton@usoncology.com Recruiting | 
| US Oncology Research and Clinical Pharmacy (Drug Shipment Only) | Fortworth, Texas, United States, 76177Contact: Jennifer Stewart | 214-778-4127 | Jennifer.Stewart2@usoncology.com Not yet recruiting | 
| US Oncology Research and Clinical Pharmacy (Drug Shipment Only) | Fortworth, Texas, United States, 76177Contact: Heather Boyd | Heather.boyd@usoncology.com Recruiting | 
| US Oncology Research and Clinical Pharmacy (Drug Shipment Only) | Fortworth, Texas, United States, 76177Contact: Jonathan Huntzinger | 214-370-1942 | Jonathan.huntzinger@usoncology.com Recruiting | 
| US Oncology Research and Clinical Pharmacy (Drug Shipment Only) | Fortworth, Texas, United States, 76177Contact: Amy Jordan | 214-346-3508 | amy.jordan@usoncology.com Recruiting | 
| Texas Oncology - Garland | Garland, Texas, United States, 75042Contact: Jennifer Stewart | 214-778-4127 | Jennifer.Stewart2@usoncology.com Not yet recruiting | 
| The University of Texas MD Anderson Cancer Center, Department of Breast Medical Oncology | Houston, Texas, United States, 77030-4009Contact: Gil R Guerra | 713-792-2860 | grguerra@mdanderson.org Recruiting | 
| Texas Oncology - Plano West | Plano, Texas, United States, 75093Contact: Jennifer Stewart | 214-778-4127 | Jennifer.Stewart2@usoncology.com Not yet recruiting | 
| Texas Oncology-Plano East | Plano, Texas, United States, 75075-7787Contact: Kristy Lee | 972-867-3577 | kristy.lee@usoncology.com Not yet recruiting | 
| Oncology & Hematology Associates of Southwest Virginia, INC., D.B.A. Blue Rigde Cancer Care | Blacksburg, Virginia, United States, 24060Contact: Joyce Whitfield | joyce.whitfield@usoncology.com Recruiting | 
| Virginia Oncology Associates | Chesapeake, Virginia, United States, 23320Contact: Elaine Wilton | 757-262-4633 | elaine.wilton@usoncology.com Recruiting | 
| Virginia Oncology Associates | Hampton, Virginia, United States, 23666Contact: Elaine Wilton | 757-262-4633 | elaine.wilton@usoncology.com Recruiting | 
| Oncology & Hematology Associates of Southwest Virginia, Inc. D.B.A Blue Ridge Cancer Care | Low Moor, Virginia, United States, 24457Contact: Joyce Whitfield | joyce.whitfield@usoncology.com Recruiting | 
| Virginia Oncology Associates | Newport News, Virginia, United States, 23606Contact: Elaine Wilton | 757-262-4633 | elaine.wilton@usoncology.com Recruiting | 
| Virginia Oncology Associates | Norfolk, Virginia, United States, 23502Contact: Elaine Wilton | 757-262-4633 | elaine.wilton@usoncology.com Recruiting | 
| Oncology & Hematology Associates of Southwest Virginia, Inc. D.B.A Blue Ridge Cancer Care | Roanoke, Virginia, United States, 24014Contact: Joyce Whitfield | joyce.whitfield@usoncology.com Recruiting | 
| Oncology & Hematology Associates of Southwest Virginia, Inc. D.B.A Blue Ridge Cancer Care | Salem, Virginia, United States, 24153Contact: Joyce Whitfield | joyce.whitfield@usoncology.com Recruiting | 
| Virginia Oncology Associates | Virginia Beach, Virginia, United States, 23456Contact: Elaine Wilton | 757-262-4633 | elaine.wilton@usoncology.com Recruiting | 
| Shenandoah Oncology, P.C. | Winchester, Virginia, United States, 22601Contact: Heather Boyd | Heather.boyd@usoncology.com Recruiting | 
| Oncology & Hematology Associates of Southwest Virginia, Inc. D.B.A Blue Ridge Cancer Care | Wytheville, Virginia, United States, 24382Contact: Joyce Whitfield | joyce.whitfield@usoncology.com Recruiting | 
| Evergreen Hospital Medical Center | Kirkland, Washington, United States, 98034Contact: Melissa Griffin | 206-288-7051 | griffmj@u.washington.edu Recruiting | 
| Seattle Cancer Care Alliance at Evergreen Health | Kirkland, Washington, United States, 98034Contact: Melissa Griffin | 206-288-7051 | griffmj@u.washington.edu Recruiting | 
| Seattle Cancer Care Alliance | Seattle, Washington, United States, 98109Contact: Melissa Griffin | 206-288-7051 | griffmj@u.washington.edu Recruiting | 
| Northwest Cancer Specialists, P.C. | Vancouver, Washington, United States, 98683Contact: Margaret E Bigler | 503-231-2612 | margaret.bigler@usoncology.com Recruiting | 
| Northwest Cancer Specialists P.C. | Vancouver, Washington, United States, 98684Contact: Margaret E Bigler | 503-231-2612 | margaret.bigler@usoncology.com Recruiting | 
| West Virginia University - Department of Medicine | Morgantown, West Virginia, United States, 26506-9162Contact: Patricia Beal | 304-293-0609 | pbeal@hsc.wvu.edu Recruiting | 
| UW Carbone Comprehensive Cancer Center | Madison, Wisconsin, United States, 53792Contact: Tamara M Koehn | tmkoehn@medicine.wisc.edu Recruiting | 
| North Coast Cancer Institute/Port Macquarie Base Hospital | Port Macquarie, New South Wales, Australia, 2444Contact: Katie Firkin Recruiting | 
| Calvary Mater Newcastle | Waratah, New South Wales, Australia, 2310Contact: Sue Brew | +61 (02) 4921-1459 | sue.brew@calvarymater.org.au Recruiting | 
| Icon Cancer Care Wesley | Auchenflower, Queensland, Australia, 4066Contact: Jane Holt | +610737374576 | jholt@hoca.com.au Recruiting | 
| Nambour General Hospital | Nambour, Queensland, Australia, 4560Contact: Karen Simmons | +61 (07) 5470-6202 | Karen.Simmons@health.qld.gov.au Recruiting | 
| Princess Alexandra Hospital | Wooloongabba, Queensland, Australia, 4102Contact: Jennifer M Suffolk | 07 317 67825 | JenniferM.Suffolk@health.qld.gov.au Recruiting | 
| Royal Adelaide Hospital, Department of Medical Oncology | Adelaide, South Australia, Australia, 5000Contact: Pushparaj Velayudham | Pushparaj.Velayudham@health.sa.gov.au Recruiting | 
| Day Oncology, Northern Hospital | Epping, Victoria, Australia, 3076Contact: Anastasia Hutchinson | +61 (03) 8405-8480 | anastasia.hutchinson@nh.org.au Recruiting | 
| Royal Melbourne Hospital | Parkville, Victoria, Australia, 3050Contact: Jaren Caine | Jaren.Caine@mh.org.au Recruiting | 
| Epworth Hospital | Richmond, Victoria, Australia, 3121Contact: Felicity Osmond | +61 (03) 9936-8055 | felicity.osmond@epworth.org.au Recruiting | 
| Maroondah Hospital | Ringwood East, Victoria, Australia, 3135Contact: Amy Tang | amy.tang@easternhealth.org.au Recruiting | 
| Bendigo Hospital | Bendigo, Australia, VIC 3550Contact: Janet Holland | +61354548821 | JHolland@bendigohealth.org.au Recruiting | 
| Kinghorn Cancer Centre / St Vincent's Hospital (Sydney) Pty Ltd | Darlinghurst, Australia, 2010Contact: Lynne Jolly | +61 2 93555617 | ljolly@stvincents.com.au Recruiting | 
| Royal Perth Hospital, Department of Medical Oncology | Perth, Australia, 6000Contact: Gabrielle Howarth | +61 8 9224 1346 | gabrielle.howarth@health.wa.gov.au Recruiting | 
| Goulburn Valley Health | Shepparton, Australia, 3630Contact: Vicki Clowes | +61 3 58323778 | vicki.clowes@gvhealth.org.au Recruiting | 
| UZ Brussel | Brussel, Belgium, 1090Contact: Alex Dewaele | 32-2-4775459 | alex.dewaele@uzbrussel.be Recruiting | 
| Oncologie | Brussels, Belgium, 1200Contact: Vanessa QUIBUS | vanessa.quibus@uclouvain.be Recruiting | 
| Institut Jules Bordet | Brussels, Belgium, 1000Contact: Berline Tako Mouafo | +32 2 541 3142 | berline.takomouafo@bordet.be Recruiting | 
| Grand Hopital de Charleroi / Service d'Hematologie et Oncologie | Charleroi, Belgium, 6000Contact: Stephanie Adam | +3271104762 | stephanie.adam@ghdc.be Recruiting | 
| Universitair Ziekenhuis Leuven - Campus Gasthuisberg | Leuven, Belgium, 3000Contact: Chantal Blomme | 32-16-34-08-30 | CHANTAL.BLOMME@UZLEUVEN.BE Recruiting | 
| CHU de Liege | Liege 1, Belgium, 4000Contact: Maude Piron | +32 4 366 71 11 bip 4454 | mpiron@chu.ulg.ac.be Recruiting | 
| Centre Hospitalier Peltzer - La Tourelle, Service de Cancerologie | Verviers, Belgium, 4800Contact: Valérie Graindorge | 32-84-212319 | valerie.graindorge@chplt.be Recruiting | 
| GZA ziekenhuizen Campus, Sint-Augustinusziekenhuis | Wilrijk, Belgium, 2610Contact: Jan Van der Eycken | +32 3 443 37 59 | cto@gza.be Recruiting | 
| Tom Baker Cancer Centre | Calgary, Alberta, Canada, T2N 4N2Contact: Marny Yar | Marny.Yar@albertahealthservices.ca Recruiting | 
| Cross Cancer Institute | Edmonton, Alberta, Canada, T6G 1Z2Contact: Ann Chisotti | 780-432-8967 | ann.chisotti@albertahealthservices.ca Recruiting | 
| BC Cancer Agency-Fraser Valley Centre | Surrey, British Columbia, Canada, V3V 1Z2Contact: Monica Fourt | 604-930-4064 | mfourt@bccancer.bc.ca Recruiting | 
| British Columbia Cancer Agency-Vancouver Centre | Vancouver, British Columbia, Canada, V5Z 4E6Contact: Shifania Premji | 16048776098 | SPremji@bccancer.bc.ca Recruiting | 
| QEII Health Sciences Centre, Victoria General Site | Halifax, Nova Scotia, Canada, B3H 2Y9Contact: Angela MacDonald | 902-473-7351 | angela.macdonald@cdha.nshealth.ca Recruiting | 
| QEII Health Sciences Centre, Nova Scotia Cancer Centre | Halifax, Nova Scotia, Canada, B3H 1V7Contact: Angela MacDonald | 902-473-7351 | angela.macdonald@cdha.nshealth.ca Recruiting | 
| London Regional Cancer Program | London, Ontario, Canada, N6A 4L6Contact: Lorraine Hewett | 519-685-8618 | Lorraine.Hewett@lhsc.on.ca Recruiting | 
| Southlake Regional Health Centre / Stronach Regional Cancer Centre | Newmarket, Ontario, Canada, L3Y2P9Contact: Shelina Sabur | 905-895-4521 ext. 2297 | SSabur@southlakeregional.org Recruiting | 
| Northeast Cancer Centre of Health Sciences North | Sudbury, Ontario, Canada, P3E 5J1Contact: Mark Whissell | 705-522-6237 x 2402 | mawhissell@hrsrh.on.ca Not yet recruiting | 
| St. Michaels Hospital | Toronto, Ontario, Canada, M5B 1W8Contact: Antonio Estacio | 416-864-6060 x 3838 | EstacioA@smh.ca Recruiting | 
| Sunnybrook Research Institute | Toronto, Ontario, Canada, M4N 3M5Contact: Tammy Taite | 416-480-5000 x 7934 | tammy.taite@sunnybrook.ca Recruiting | 
| Princess Margaret Hospital - University Health Network | Toronto, Ontario, Canada, M5G 2M9Contact: Lindsay Culala | Lindsay.Culala@uhn.ca Recruiting | 
| Royal Victoria Hospital | Montreal, Quebec, Canada, H3A 1A1Contact: Rajesh Sharma | 514-934-1934 Ext: 35920 | rajesh.sharma@muhc.mcgill.ca Recruiting | 
| St. Mary's Hospital | Montreal, Quebec, Canada, H3T 1M5Contact: Rajesh Sharma | 514-934-1934 Ext: 35920 | rajesh.sharma@muhc.mcgill.ca Recruiting | 
| Hopital du Sacre-Coeur | Montreal, Quebec, Canada, H4JIC5Contact: Anne-Marie Laliberté | 514-338-2222 ext. 2818 | anne-marie.laliberte@crhsc.rtss.qc.ca Recruiting | 
| Jewish General Hospital | Montreal, Quebec, Canada, H3T 1E2Contact: Rajesh Sharma | 514-934-1934 Ext: 35920 | rajesh.sharma@muhc.mcgill.ca Recruiting | 
| Allan Blair Cancer Centre | Regina, Saskatchewan, Canada, S4T 7T1Contact: Joanne Allen | 306-766-2554 | joanne.allen@saskcancer.ca Recruiting | 
| Center Hospitalier Affilie Universitaire de Quebec, Hopital du Saint Sacrement | Quebec, Canada, G1S 4L8Contact: Eric Vachon | 418-682-7511 ext. 4728 | eric.vachon.cha@ssss.gouv.qc.ca Recruiting | 
| Compr Cancer Ctr of University Hospital Hradec Kralove | Hradec Kralove, Czech Republic, 500 05Contact: Simona Sediva | +420 495832489 | simona.sediva@fnhk.cz Recruiting | 
| Fakultni nemocnice Olomouc | Olomouc, Czech Republic, 775 20Contact: Monika Steckerova | 011420588442522 | monika.steckerova@fnol.cz Not yet recruiting | 
| Institut de Cancerologie de I'Ouest-Paul Papin | Angers Cedex 9, France, 49933Contact: Pierre Celea | +33 2 41 35 27 00 | Pierre.Celea@ico.unicancer.fr Recruiting | 
| Centre François Baclesse | Caen Cedex 5, France, 14076Contact: Sara Grossi | +33 2 31 45 51 87 | s.grossi@baclesse.fr Recruiting | 
| Centre Georges François Leclerc | Dijon Cedex, France, 21079Contact: Erwan PETIT | + 33 3 80 73 77 56 | epetit@dijon.fnclcc.fr Recruiting | 
| Centre hospitalier Departemental les Oudairies | La Roche-Sur-Yon, France, 85025Contact: Isabelle Lepage | +33251446161 | isabelle.lepage@chd-vendee.fr Recruiting | 
| Centre Oscar Lambret | Lille, France, 59020Contact: nathalie devienne | 03.20.29.59.35 | n-devienne@o-lambret.fr Not yet recruiting | 
| Centre Val d'Aurelle, | Montpellier CEDEX 5, France, 34298Contact: Christine Gestin Boyer | 33-4-67-61-25-15 | Christine.Gestin-Boyer@icm.unicancer.fr Not yet recruiting | 
| Centre Antoine Lacassagne | Nice cedex 2, France, 06189Contact: Beatrice De Clercq | +334 92 03 16 62 | beatrice.declercq@nice.unicancer.fr Recruiting | 
| Institut Curie, Département d'Oncologie Médicale | Paris Cedex 05, France, 75248Contact: Daisylia Delanoe | +33 (0) 1.56.24.56.39 | daisylia.delanoe@curie.fr Recruiting | 
| Institut Jean Godinot | Reims, France, 51056Contact: Sandrine Meunier | + 33 3 26 50 44 85 | Sandrine.MEUNIER@reims.unicancer.fr Not yet recruiting | 
| Centre Eugene Marquis | Rennes, France, 35062Contact: Manuel Croix | +33 2 99 25 29 35 | m.croix@rennes.unicancer.fr Recruiting | 
| Institut Curie - Hopital Rene Huguenin | Saint-Cloud, France, 92210Contact: Mitra Coulon | 01-47-11-23-81 (Poste 30 36) | mitra.coulon@curie.fr Recruiting | 
| Centre Rene Gauducheau | St Herblain, France, 44805Contact: Severine Maury | 0240679167 | Severine.Maury@ico.unicancer.fr Not yet recruiting | 
| Institut Claudius Regaud | Toulouse, France, 31000Contact: Marta Dabek | 33 (0)5 67 22 27 54 | Dabek.Marta@claudiusregaud.fr Recruiting | 
| Institut Gustave Roussy | Villejuif, France, 94805Contact: Aranjah Thevarajah | + 33 (0)1 42 11 42 11 (poste 3 | Aranjah.THEVARAJAH@igr.fr Recruiting | 
| University of Kiel | Kiel, SH, Germany, 24105Contact: Silke Kassner | 0049-431-597 4089 | sgo@uksh.de Recruiting | 
| Klinikum St. Marien | Amberg, Germany, 92224Contact: Jacqueline Roy | +49-9621-381381 | roy.jacqueline@klinikum-amberg.de Not yet recruiting | 
| Klinikverbund Sudwest - Kliniken Sidelfingen-Boblingen | Boeblingen, Germany, 71032Contact: Silke Biermann | +49703166829114 | S.Biermann@klinikverbund-suedwest.de Recruiting | 
| Universitaetsklinikum Dresden | Dresden, Germany, 01307Contact: Christine Leffler | 0049-351-458 3508 | Christine.Leffler@uniklinikum-dresden.de Recruiting | 
| Universitaetsklinikum Erlangen, Klinik fuer Frauenheilkunde | Erlangen, Germany, 91054Contact: Saskia Langner | +49-9131-8536167 | saskia.langner@uk-erlangen.de Recruiting | 
| Klinik Esslingen - Klinik Fur Frauenheilkunde Und Geburtshilfe | Esslingen am Neckar, Germany, 73730Contact: Angelika Jursik | +49 711 3103 3064 | angelikajursik@gmx.de Not yet recruiting | 
| Uniklinik Frankfurt | Frankfurt, Germany, 60590Contact: Stefan M Loitsch | +49-69-6301-6850 | stefanmarcel.loitsch@kgu.de Not yet recruiting | 
| Staedtische Kliniken Frankfurt am Main-Hoechst Frauenklinik | Frankfurt am Main, Germany, 65929Contact: Christina Weissmueller | +496930059945 | christina.weissmueller@skfh.de Not yet recruiting | 
| Klinikum Fulda gAG | Fulda, Germany, 36043Contact: Kerstin Bellof-Thrams | +49 661 84 5487 | kerstin.bellof-thrams@klinikum-fulda.de Not yet recruiting | 
| Universitaetsklinikum Hamburg-Eppendorf | Hamburg, Germany, 20246Contact: Krenkel Sylke | +49 40 7410 58130 | s.krenkel@uke.de Recruiting | 
| St. Elisabeth-Kh - Gynakologie | Koeln, Germany, 50924Contact: Gabriele Haarmann | Gabriele.Haarmann@hohenlind.de Not yet recruiting | 
| Universitaetsklinikum Magdeburg A.oe.R. | Magdeburg, Germany, 39108Contact: Christel Besseler | 0391/6717438 | christel.besseler@med.ovgu.de Recruiting | 
| Katholisches Klinikum Mainz | Mainz, Germany, 55131Contact: Ursula Winter | +496131-575 831420 | gyn-onk@kkmainz.de Recruiting | 
| Frauenklinik und Poliklinik Klinikum rechts der Isar, Technische Universitaet Muenchen | Muenchen, Germany, 81675Contact: Rita Rosenkranz | +498941406629 | rita.rosenkranz@mri.tum.de Recruiting | 
| Klinikum Grosshadern | Muenchen, Germany, 81337Contact: Gabriele Breu | +49 89 5160-4317 | gabriele.breu@med.uni-muenchen.de Recruiting | 
| Onkologische Praxis Muenchen | Muenchen, Germany, 80336Contact: Simone Schiersner | +49 89-599888830 | S.Schiersner@ioz-muenchen.de Recruiting | 
| Rotkreuzklinikum Munchen Gmbh | München, Germany, 80637Contact: Harry Reisch | +49-89-15706-661 | harry.reisch@swmbrk.de Recruiting | 
| Universitätsfrauenklinik und Poliklinik am Klinikum Südstadt Rostock | Rostock, Germany, 18059Contact: Beatrice Engel | 0049 381 4401-6143 | beatrice.engel@kliniksued-rostock.de Not yet recruiting | 
| Mutterhaus der Borromaeerinnen, Innere Medizin I | Trier, Germany, 54290Contact: Ali Reza Waladkhani | +496519472571 | waladkhani@mutterhaus.de Recruiting | 
| Országos Onkológiai Intézet | Budapest, Hungary, 1122Contact: Rita Fozo | +36-20-225-7653 | rita.fozo@coordination.hu Recruiting | 
| Semmelweis Egyetem Általános Orvostudományi Kar | Budapest, Hungary, 1083Contact: Andrea Makra | +36206663185 | trial.sote@gmail.com Not yet recruiting | 
| Szent Margit Korhaz Onkologia | Budapest, Hungary, 1032Contact: Zsuzsanna Toth | +3612502420 ext. 1270 | zsuzsanna.toth@coordination.hu Recruiting | 
| Petz Aladar Megyei Oktato Korhaz, Onkoradiologia | Gyor, Hungary, 9024Contact: Marta Janoki | +36 70 451-05-68 | janoki.m@gmail.com Recruiting | 
| Petz Aladar Megyei Oktato Korhaz | Gyor, Hungary, 9024Contact: Marta Janoki | +36 70 451-05-68 | janoki.m@gmail.com Recruiting | 
| Josa Andras Hospital | Nyiregyhaza, Hungary, 4400Contact: Angela Litvai | +3642599700 ext. 1895 | litvai.angela@szszbmk.hu Recruiting | 
| Szegedi Egyetem Onkologiai Klinika | Szeged, Hungary, 6720Contact: Iren Tanczos | 36-62-544943 | tanczika70@freemail.hu Recruiting | 
| Bon Secours Hospital | Cork, IrelandContact: Sarah Thompson | +353 (0) 21 454 28072663 P | sthompson@bonsecours.ie Recruiting | 
| Mater Misericordiae University Hospital | Dublin, Ireland, Dublin 7Contact: Martina Smith | +353 (0)1 8034834 | msmith@mater.ie Recruiting | 
| Beaumont Hospital | Dublin, Ireland, 9Contact: Derval Kehily | +353 (0)1 8092010 | dervalkehily@beaumont.ie Recruiting | 
| St. James Hospital | Dublin, Ireland, 8Contact: Ingrid Kiernan | +353 1 4103754 | ikiernan@stjames.ie Recruiting | 
| St Vincents University Hospital | Dublin 4, IrelandContact: Deirdre McDonnell | 00353 1 2214893 | deirdre.mcdonnell@ccrt.ie Recruiting | 
| Mater Private Hospital | Dublin 7, IrelandContact: Martina Smith | +353 (0) 1 8034834 | msmith@mater.ie Not yet recruiting | 
| Department of Medical Oncology | Galway, IrelandContact: Mary Byrne | +353 (0) 91 542954 | marymarg.byrne@hse.ie Recruiting | 
| Mid Western Regional Hospital | Limerick, IrelandContact: Melissa Browne | +35361485148 | melissa.browne@hse.ie Recruiting | 
| Waterford Regional Hospital | Waterford, IrelandContact: Flordeliza Calacsan | 00353 51 848590 | Flordeliza.Calacsan@hse.ie Recruiting | 
| Divisione Oncologia Medica Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, IRST | Meldola, FC, Italy, 47014Contact: Daniele Andreis | +39 0543 739264 | d.andreis@irst.emr.it Recruiting | 
| IRCCS - Istituto Europeo di Oncologia | Milano, Milan, Italy, 20141Contact: Claudia Sangalli | +390257489840 | claudia.sangalli@ieo.it Recruiting | 
| Azienda Ospedaliera San Giuseppe Moscati | Avellino, Italy, 83100 Not yet recruiting | 
| Policlinico Sant'Orsola-Malpighi | Bologna, Italy, 40138Contact: Sara Tomasini | +390516364547 | sara.tomasini@aosp.bo.it Not yet recruiting | 
| Universita' Degli Studi di Napoli Federico II | Napoli, Italy, 80131Contact: Antonio Pepe | 39-081-7463662 | studiclinici.oncologia@unina.it Not yet recruiting | 
| Azienda Ospedaliero-Universitaria Pisana | Pisa, Italy, 56126Contact: Cinzia Orlandini | 39-050-993173 | c.orlandini@med.unipi.it Not yet recruiting | 
| Istituto Regina Elena - Struttura Complessa Oncologia Medica A | Roma, Italy, 00144Contact: Ilaria Carbone | 39-06-52662745 | carbone.ilax@yahoo.it Recruiting | 
| Ospedale SS Trinita | Sora (FR), Italy, 03039 Recruiting | 
| Aichi Cancer Center Hospital | Nagoya, Aichi, JapanContact: Akemi Katayama | jutaku_n@aichi-cc.jp Recruiting | 
| National Cancer Center Hospital East | Kashiwa, Chiba, JapanContact: Yuko Ito | +81-4-7133-1111 | yukito@east.ncc.go.jp Recruiting | 
| National Hospital Organization Hokkaido Cancer Center | Sapporo, Hokkaido, JapanContact: Shinya Takada | 81-11-811-9111 | cr12@sap-cc.go.jp Recruiting | 
| Saitama Cancer Center | Kita-adachi-gun, Saitama, JapanContact: Yoko Kinokiri | 01181353192723 | y-kinokiri@epmint.co.jp Recruiting | 
| National Cancer Center Hospital | Chuo-Ku, Tokyo, JapanContact: Rie Nakano | +81-3-3542-2511 | rnakano@ncc.go.jp Recruiting | 
| Chiba Cancer Center | Chiba, JapanContact: Chiyoko Motomura | 81-43-264-5431 | cmotomura@chiba-cc.jp Recruiting | 
| National Hospital Organization Shikoku Cancer Center | Ehime, JapanContact: Mika Okamoto | 01181899991111 | mokamoto@shikoku-cc.go.jp Recruiting | 
| National Hospital Organization Kyushu Cancer Center | Fukuoka, JapanContact: Kiyo Aramaki | 01181925413231 | karamaki@nk-cc.go.jp Recruiting | 
| Hiroshima City Hospital | Hiroshima, JapanContact: Miki Ichisawa | 81-82-221-5233 | m-ichisawa@epmint.co.jp Recruiting | 
| Iwate Medical University Hospital | Iwate, JapanContact: Yukiko Honda | 81196515111 | yukiko.honda@j.iwate-med.ac.jp Recruiting | 
| Hakuaikai Medical Corporation Sagara Hospital | Kagoshima, JapanContact: Yuka Hidaka | 81-99-224-1800 | yuka-hidaka@sagara.or.jp Recruiting | 
| Kumamoto University Hospital | Kumamoto, JapanContact: Rumiko Minami | 81-96-373-5842 | minami-kmm@umin.ac.jp Recruiting | 
| Kumamoto City Hospital | Kumamoto, JapanContact: eriko taguchi | 81-90-1996-8111 | taguchi@csnt.co.jp Recruiting | 
| Niigata Cancer Center Hospital 2-15-3 | Niigata, JapanContact: Akiko Oya | 81-25-266-5111 | akiko-o@niigata-cc.jp Recruiting | 
| National Hospital Organization Osaka National Hospital | Osaka, JapanContact: Kaoru Ishiyama | 81669463581 | ishiyama@onh.go.jp Recruiting | 
| National Cancer Center, Center for Breast Cancer | Goyang-si, Gyeonggi-do, Korea, Republic of, 410-769Contact: Ji Hee Kim | +82-31-920-0417 | 73206@ncc.re.kr Recruiting | 
| Seoul National University Bundang Hospital | Seongnam-si, Gyeonggi-do, Korea, Republic of, 463-707Contact: Eun Kyung Kim | +82-31-787-4880 | pulssaugi@naver.com Recruiting | 
| Severance Hospital, Yonsei University Health System | Seodaemun-Gu, Seoul, Korea, Republic of, 120-725Contact: Are-rang Oh | +82-2-2228-8024 | forefeel22@naver.com Recruiting | 
| Seoul National University Hospital / Department of Internal Medicine | Seoul, Korea, Republic of, 110-744Contact: Hae Eun Kim | kheun8062@naver.com Recruiting | 
| Asan Medical Center, Division of Oncology, Department of Internal Medicine | Seoul, Korea, Republic of, 138-736Contact: Shin Ae Park | 55phon@amc.seoul.kr Recruiting | 
| Samsung Medical Center, Division of Hematology-Oncology, Department of Medicine | Seoul, Korea, Republic of, 135-710Contact: Ji Young Kwon | 82-2-3410-0953 | jiyoung31.kwon@samsung.com Recruiting | 
| Christchurch Hospital | Christchurch, Canterbury, New Zealand, 8011Contact: Katharine Moore | +64 3 364 1823 | Katharine.moore@cdhb.health.nz Not yet recruiting | 
| Uniwersyteckie Centrum Kliniczne | Gdańsk, Poland, 80-952Contact: Anita Zakrzewska | +48 58 349 2282 | zakrzewska@gumed.edu.pl Recruiting | 
| Europejskie Centrum Zdrowia Otwock | Otwock, Poland, 05-400Contact: Magdalena Granat | 48-22-6440024 | magdac@coi.waw.pl Not yet recruiting | 
| Wojskowy Instytut Medyczny, Klinika Onkologii CSK MON, ul. Szaserow 128 | Warszawa, Poland, 04-141Contact: Agata Kielkiewicz | 48-22-6103098 | akielkiewicz@wim.mil.pl Not yet recruiting | 
| Niepubliczny Zakład Opieki Zdrowotnej "Onko-Dent" SP.P. G.L. Słomian | Zory, Poland, 44-240Contact: Urszula Lanucha-Wajzer | +48 32 469 04 25 | salomea@autograf.pl Not yet recruiting | 
| Regional Budgetary Healthcare Institution Kursk Regional Clinical | Kursk, Kursk Region, Russian FederationContact: Irina Sudakova | +7(906)6912374 | isudakova46@gmail.com Recruiting | 
| State Budget Healthcate Institution "Leningrad Region Oncology Dispensary" | Kuzmolovo, Leningrad region, Russian Federation, 188663 Recruiting | 
| State Medical Care Institution | Chelyabinsk, Russian Federation, 454087Contact: Svetlana Markova | 7 351 232 93 76 | gladkov_o@rambler.ru Not yet recruiting | 
| GUZ Republic Clinical Oncology Dispensary of Ministry of Health of Republic of Tatarstan | Kazan, Russian Federation, 420029Contact: Svetlana Fazulyanova Recruiting | 
| City Oncology Clinical Hospital #62, Chemotherapy Department | Moscow, Russian Federation, 143423Contact: Lyubov Krasnolutskaya | 7-495-536-0100 | protocol-62@mail.ru Recruiting | 
| Federal State Budget Institution | Moscow, Russian Federation, 115478Contact: Svetlana Khokhlova | +7 499 324 9479 | svkhokhlova@mail.ru Recruiting | 
| State Budget Institution of Healthcare | Omsk, Russian Federation, 644046Contact: Ivan Tsygankov | oncoomsk@mail.ru Recruiting | 
| State Budget Institution of Healthcare | Omsk, Russian Federation, 644013Contact: Ivan Tsygankov | oncoomsk@mail.ru Recruiting | 
| Ryazan Regional Clinical Oncology Dispensary | Ryazan, Russian Federation, 390011Contact: Ilya B Sudakov | 7-491-244-88-25 | Sudakovil@yandex.ru Not yet recruiting | 
| State educational institution of higher education "Ryazan State Medical University named after IP Pa | Ryazan, Russian Federation, 390026Contact: Ilya B Sudakov | 7-491-244-88-25 | Sudakovil@yandex.ru Not yet recruiting | 
| Saint-Petersburg State Budget Healthcare Institution (SBHCI) | Saint-Petersburg, Russian Federation, 197022Contact: Tatyana Kotkova | kotkova95@mail.ru Not yet recruiting | 
| Non-state institution of Healthcare "Railway Clinical Hospital at OJSC "RR" | St. Petersburg, Russian Federation, 195271Contact: Konstantin Penkov | penkov76@gmail.com Recruiting | 
| State Budget Medical Institution Republican Clinical Oncology | Ufa, Russian Federation, 450054Contact: Leysyan Mirkhaydarova | lmirkhaydarova@bk.ru Recruiting | 
| Hospital Universitari Germans Trias i Pujol | Badalona, Barcelona, Spain, 08916Contact: Saudy Patricia Pelaez Bonilla | +34-934978729 | pelaezbonilla.saudy@gmail.com Recruiting | 
| Consorci Sanitari de Terrassa | Terrassa, Barcelona, Spain, 08227Contact: Carme Aracil | 01134937003612 | caracil@cst.cat Recruiting | 
| Hospital Universitari Son Espases | Palma de Mallorca, Islas Baleares, Spain, 07010Contact: Joana Maria Mascaro Ferrer | +34-671-03-26-20 | juanam.mascaro@ssib.es Recruiting | 
| Hospital Universitario Fundacion de Alcorcon | Alcorcon, Madrid, Spain, 28922Contact: Ruth Martinez Cabañes | +34-916219256 | rmartinezca@fhalcorcon.es Recruiting | 
| Hospital Universitario Infanta Cristina | Badajoz, Spain, 06080Contact: Paloma Moyano Lopez | 34 924 21 80 40 X 48350 | palomamoyano@gmail.com Recruiting | 
| Hospital Universitari Vall d'Hebron | Barcelona, Spain, 08035Contact: Anna Serrano Fargas | +34 93 274 60 00 X 4707 | aserrano@vhebron.net Recruiting | 
| Hospital Clinic I Provincial | Barcelona, Spain, 08036Contact: Montserrat Fontanillas Isern | +34932275400 x 3456 | mfontani@clinic.cat Recruiting | 
| Hospital del Mar | Barcelona, Spain, 08003Contact: Clara Carreras Vila | +34 93 248 36 09 | CCarreras@imas.imim.es Recruiting | 
| Hospital de Donostia | Donostia- San Sebastian, Spain, 20014Contact: Maria Diez Zubizarreta | +34-943006002 | maria.diez@biodonostia.org Recruiting | 
| Complejo Hospitalario de Jaen | Jaen, Spain, 23007Contact: Monica Fernandez Navarro | +34953220306 | oncojaen@fibao.es Recruiting | 
| Instituto Catalan de Oncologia L'Hospitalet | L'Hospitalet de Llobregat (Barcelona), Spain, 08908Contact: marta pamias nogue | +34-932607333 | mpamies@iconcologia.net Recruiting | 
| Centro Oncologico de Galicia | La Coruna, Spain, 15009Contact: Begoña Uriarte Carbon | 0034 981 287 499 Ext. 324 | Uriarte.b@gmail.com Recruiting | 
| Hospital Universitario de Canarias | La Laguna (Santa Cruz de Tenerife), Spain, 38320Contact: Lucas De Vera | +34922678745 | lucasdevera.huc@hotmail.com Recruiting | 
| Hospital Universitario Arnau De Vilanova de Lleida | Lleida, Spain, 25198Contact: David Martinez Ortin | +34973705342 | eoncolleida@gmail.com Recruiting | 
| Hospital Madrid Universitario Sanchinarro | Madrid, Spain, 28050Contact: Miriam Delgado Sanchez | +34 91 756 78 00 Ext - 4816 | mdelgado@hmhospitales.com Recruiting | 
| Centro Oncologico MD Anderson Internacional España | Madrid, Spain, 28033Contact: Maria Jose Lopez de Paredes | 01134917878600 | mjlopez.fundacion@mdanderson.es Recruiting | 
| Hospital General Universitario Gregorio Marañon | Madrid, Spain, 28007Contact: Sara Fernandez Gonzalez | 0034 91 330 30 00 ext 7545 | sarafergon@hotmail.com Recruiting | 
| Hospital Clinico San Carlos | Madrid, Spain, 28040Contact: Sara Fernandez Gonzalez | 0034 91 330 30 00 ext 7545 | sarafergon@hotmail.com Recruiting | 
| Hospital 12 de Octubre | Madrid, Spain, 28041Contact: Rosa Rodriguez Notario | +34 913908626 | rrnotario@h12o.es Recruiting | 
| Hospital Universitario Virgen del Rocio | Sevilla, Spain, 41013Contact: Maria Angeles Oyarzabal Cespedes | 01134955012000 | ensayosclinicos.hvr.sspa@juntadeandalucia.es Recruiting | 
| Hospital Universitario Virgen Macarena | Sevilla, Spain, 41009Contact: Maria Angeles Lobo Acosta | +34955926578 | oncomacarena@gmail.com Recruiting | 
| Instituto Valenciano de Oncologia | Valencia, Spain, 46009Contact: Laura Calabuig Bendicho | +34961114013 | coordinacion@fincivo.org Recruiting | 
| Veterans General Hospital-Taipei | Taipei, ROC, Taiwan, 112Contact: Shu-Hui Yueh | oe0922@yahoo.com.tw Not yet recruiting | 
| National Taiwan University Hospital | Taipei, Taiwan, 106Contact: Ching-Yueh Cheng | loverene5122@gmail.com Recruiting | 
| Municipal Institution "City Multi-field Clinical Hospital #4 of Dnipropetrovsk Regional Council" | Dnipropetrovsk, Ukraine, 49102Contact: Iliya Balakin | 380-56-377-7797 | oncodsma@ukr.net Recruiting | 
| Kharkiv Regional Clinical Oncology Hospital | Kharkiv, Ukraine, 61070Contact: Nataliia Kryzhanovska | +38 057 315 1248 | natali.krz@gmail.com Recruiting | 
| Lviv State Oncologic Regional Treatment and Diagnostic Center | Lviv, Ukraine, 79031Contact: Ivanna Duda | +38 032 295 6306 | ivankaduda@ukr.net Recruiting | 
| Makiivka City Hospital n2 of Donetsk Region | Makiivka, Ukraine, 86120Contact: Tetiana Kuliaba | +38 062 320 12 34 | dubrova_t@mail.ru Recruiting | 
| Sumy Regional Clinical Oncology Dispensary | Sumy, Ukraine, 40005Contact: Oleksandr I Vynnchenko | +380542781306 | vynnychenkool@ukr.net Recruiting | 
| Institute of Postgraduate education and preuniversity preparing of Uzhgorod National University | Uzhgorod, Ukraine, 88000Contact: Marta Melnyk | +380312642145 | melnyk-m@yandex.ua Recruiting | 
| Zaporizhzhia Regional Clinical Oncology Dispensary | Zaporizhzhya, Ukraine, 69040Contact: Feroz Shah | 380-61-287-03-59 | f_shah@ukr.net Recruiting | 
| Kent Oncology Department | Maidstone, Kent, United Kingdom, ME16 9QQContact: Clare Calvert | 00 44 (0) 1622 227078 | clare.calvert@nhs.net Recruiting | 
| Medical Oncology, Christie Hospital | Withington, Manchester, United Kingdom, M20 4BXContact: Jagtar Sandhu | (0161) 446 8604 | Jagtar.Sandhu@christie.nhs.uk Not yet recruiting | 
| Beatson Institute for Cancer Research | Glasgow, Scotland, United Kingdom, G12 0YNContact: Jill Flemming | 00 44 141 301 7230internal 57 | Jill.Fleming@glasgow.ac.uk Recruiting | 
| The Royal Marsden NHS Foundation Trust | Sutton, Surrey, United Kingdom, SM2 5PTContact: Lyra Del Rosario | 0207 352 8171 ext: 2712 / 4652 | Lyra.DelRosario@rmh.nhs.uk Recruiting | 
| Western General Hospital | Edinburgh, United Kingdom, EH4 2XUContact: Paul Ramage | Paul.Ramage@nhslothian.scot.nhs.uk Recruiting | 
| Charing Cross Hospital | London, United Kingdom, W6 8RFContact: Kathryn Brownless | 020 3313 0664 | Kathryn.Brownless@imperial.nhs.uk Recruiting | 
| Guy's and St. Thomas' NHS Foundation Trust | London, United Kingdom, SE1 9RTContact: Claire Partridge | 0207 188 7188 ext 51694 | claire.partridge@gstt.nhs.uk Not yet recruiting | 
