Nilutamide

Nilutamide treats prostate cancer. Can cause hot flashes.

Nilutamide Overview

Reviewed: September 24, 2013
Updated: 

Nilutamide is a prescription medication used together with surgery to treat prostate cancer. Nilutamide belongs to a group of drugs called antiandrogens. It works by blocking the effects of testosterone (a male hormone), to stop the growth and spread of prostate cancer cells.

This medication comes in tablet form. It is taken once daily, with or without food.

Common side effects include nausea, constipation, and hot flashes. Nilutamide can cause dizziness. Do not drive or operate heavy machinery until you know how it affects you.

How was your experience with Nilutamide?

First, a little about yourself

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What are you taking Nilutamide for?

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  • Other
  • Carcinoma
  • Prostatic Neoplasms

How long have you been taking it?

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  • Less than a week
  • A couple weeks
  • A month or so
  • A few months
  • A year or so
  • Two years or more

How well did Nilutamide work for you?

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Uses of Nilutamide

Nilutamide is a prescription medication used to treat prostate cancer in men who have had surgery to remove the testicles (known medically as surgical castration).

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

Nilutamide Brand Names

Nilutamide may be found in some form under the following brand names:

Nilutamide Drug Class

Nilutamide is part of the drug class:

Side Effects of Nilutamide

Common side effects include:

  • constipation
  • hot flashes
  • nausea
  • headache
  • dizziness
  • impaired vision

This is not a complete list of nilutamide side effects. Ask your doctor or pharmacist for more information.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Nilutamide FDA Warning

Interstitial Pneumonitis

Interstitial pneumonitis has been reported in 2% of patients in controlled clinical trials in patients exposed to nilutamide. A small study in Japanese subjects showed that 8 of 47 patients (17%) developed interstitial pneumonitis. Reports of interstitial changes including pulmonary fibrosis that led to hospitalization and death have been reported rarely post-marketing. Symptoms included exertional dyspnea, cough, chest pain, and fever. X-rays showed interstitial or alveolo-interstitial changes, and pulmonary function tests revealed a restrictive pattern with decreased DLco. Most cases occurred within the first 3 months of treatment with nilutamide, and most reversed with discontinuation of therapy. A routine chest X-ray should be performed prior to initiating treatment with nilutamide. Baseline pulmonary function tests may be considered. Patients should be instructed to report any new or worsening shortness of breath that they experience while on nilutamide. If symptoms occur, nilutamide should be immediately discontinued until it can be determined if the symptoms are drug related.