Mepsevii

Mepsevii treats Mucopolysaccharidosis VII (MPS VII), or Sly syndrome. Mepsevii is given every 2 weeks by a healthcare professional.

Mepsevii Overview

Reviewed: December 14, 2017
Updated: 

Mepsevii is a prescription medication used to treat Mucopolysaccharidosis VII (MPS VII), or Sly syndrome, in children and adults. Mucopolysaccharidosis VII is a disorder where there is a deficiency in an enzyme that breaks down sugars in the body.

Mepsevii belongs to a group of drugs called enzyme replacement therapy. These work by providing an enzyme in which patients who have Sly syndrome are deficient.

This medication is available in an injectable form to be given directly into a vein (IV) by a healthcare professional.

Common side effects of Mepsevii include infusion site reaction, diarrhea, and rash.

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Mepsevii Cautionary Labels

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Uses of Mepsevii

Mepsevii is a prescription medication used to treat Mucopolysaccharidosis VII (MPS VII), or Sly syndrome, in children and adults. Mucopolysaccharidosis VII is a disorder in which there is a deficiency in an enzyme that breaks down sugars in the body.

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

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For more information on this medication choose from the list of selections below.

Side Effects of Mepsevii

Serious side effects have been reported with Mepsevii. See the “Mepsevii Precautions” section.

Common side effects of Mepsevii include the following:

  • reaction at the infusion site
  • diarrhea
  • rash
  • allergic reaction
  • swelling of the hands, arms, feet, or legs
  • itching

This is not a complete list of Mepsevii side effects. Ask your doctor or pharmacist for more information.

Tell your doctor if you have any side effects that bother you or that do not go away.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Mepsevii Interactions

No drug interactions have been determined by the manufacturer. However, you should tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements. Not all drug interactions are known or reported and new drug interactions are continually being reported.

Mepsevii Precautions

Serious side effects have been reported with Mepsevii including the following:

  • anaphylaxis (severe allergic reaction). Tell your healthcare provider about any signs or symptoms of hypersensitivity, which include the following:
    • swelling of face, eyes, lips, tongue, larynx and extremities
    • difficulty breathing or swallowing
    • rash or skin reactions
    • low blood pressure or dizziness
    • a weak or rapid heart rate
    • nausea, vomiting or diarrhea

Do not take Mepsevii if you are allergic to Mepsevii or to any of its ingredients.

Mepsevii Food Interactions

Medications can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of Mepsevii, there are no specific foods that you must exclude from your diet when receiving this medication.

Inform MD

Before taking Mepsevii, tell your doctor about all of your medical conditions. Especially tell your doctor if you:

  • are allergic to Mepsevii or to any of its ingredients
  • are pregnant or plan to become pregnant
  • are breastfeeding or plan to breastfeed

Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements.

Mepsevii and Pregnancy

Tell your doctor if you are pregnant or plan to become pregnant.

There are no well-done studies that have been done in humans with Mepsevii. In animal studies, pregnant animals were given this medication, and the babies did not show any medical issues related to this medication.

Mepsevii and Lactation

Tell your doctor if you are breastfeeding or plan to breastfeed.

It is not known if Mepsevii crosses into human milk. Because many medications can cross into human milk and because of the possibility for serious adverse reactions in nursing infants with use of this medication, a choice should be made whether to stop nursing or stop the use of this medication. Your doctor and you will decide if the benefits outweigh the risk of using Mepsevii.

Mepsevii Usage

This medication is available in an injectable form to be given directly into a vein (IV) by a healthcare professional.

Your healthcare provider may decide to give you medications, including a non-sedating antihistamine with or without a fever-reducing medication, 30 minutes to 1 hour before the start of infusion.

If you miss a dose, talk to your healthcare provider.

Mepsevii Dosage

The recommended dose of Mepsevii for the treatment of Mucopolysaccharidosis VII, or Sly syndrome, is based on your weight. Mepsevii is given every 2 weeks into a vein (IV) by a healthcare provider.

Mepsevii Overdose

Mepsevii is administered by a healthcare provider in a medical setting making it unlikely that an overdose will occur. However, if overdose is suspected, seek emergency medical attention.

Other Requirements

  • Keep all appointments with your doctor.

Mepsevii FDA Warning

WARNING: ANAPHYLAXIS

  • Anaphylaxis has occurred with Mepsevii administration, as early as the first dose, therefore appropriate medical support should be readily available when MEPSEVII is administered. 
  • Closely observe patients during and for 60 minutes after Mepsevii infusion.
  • Immediately discontinue the Mepsevii infusion if the patient experiences anaphylaxis.