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Epidiolex is used to treat seizures associated with Lennox-Gastaut syndrome or Dravet syndrome in patients 2 years of age and older. This medication may make you feel sleepy.

Epidiolex Overview

Reviewed: July 5, 2018

Epidiolex is a prescription medication used to treat seizures associated with Lennox-Gastaut syndrome or Dravet syndrome in patients 2 years of age and older.

Epidiolex belongs to a group of drugs called cannabinoids. It is believed to work differently from other prescription seizure medicines, but the exact mechanisms of action (how it works) are unknown.

This medication comes in oral solution form and is taken 2 times a day with or without food.

Epidiolex can cause sleepiness. Do not drive or operate heavy machinery until you know how Epidiolex affects you. Other common side effects include decreased appetite, diarrhea, and increased liver enzymes.

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Uses of Epidiolex

Epidiolex is a prescription medication used to used to treat seizures associated with Lennox-Gastaut syndrome or Dravet syndrome in patients 2 years of age and older.

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

Side Effects of Epidiolex

Serious side effects have been reported with Epidiolex. See the “Epidiolex Precautions” section.

Common side effects of Epidiolex include the following:

  • Sleepiness
  • Decreased appetite
  • Diarrhea
  • Increase in liver enzymes
  • Feeling tired and weak
  • Rash
  • Sleep problems
  • Infections

This is not a complete list of Epidiolex side effects. Ask your doctor or pharmacist for more information.

Tell your doctor if you have any side effects that bother you or that do not go away.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Epidiolex Food Interactions

Medications can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of Epidiolex, high-fat/high-calorie meals should be avoided because they can greatly increase the concentration of the medication. Talk to your health care provider about the best way to take this medication.

Inform MD

Before taking Epidiolex, tell your doctor about all of your medical conditions. Especially tell your doctor if you:

  • are allergic to Epidiolex or to any of its ingredients
  • have or have had depression, mood problems or suicidal thoughts or behavior
  • have liver problems
  • have abused or been dependent on prescription medicines, street drugs or alcohol
  • are pregnant or plan to become pregnant
  • are breastfeeding or plan to breastfeed

Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements.

Epidiolex and Pregnancy

Tell your doctor if you are pregnant or plan to become pregnant.

In animal studies, pregnant animals were given this medication and had some babies born with problems. No well-controlled studies have been done in humans. Therefore, this medication may be used if the potential benefits to the mother outweigh the potential risks to the unborn child.

If you become pregnant while taking Epidiolex, talk to your healthcare provider about registering with the North American Antiepileptic Drug Pregnancy Registry. You can enroll in this registry by calling 1-888-233-2334. The purpose of this registry is to collect information about the safety of antiepileptic medicines during pregnancy.

Epidiolex and Lactation

Tell your doctor if you are breastfeeding or plan to breastfeed.

It is not known if Epidiolex crosses into human milk. Because many medications can cross into human milk and because of the possibility for serious adverse reactions in nursing infants with use of this medication, a choice should be made whether to stop nursing or stop the use of this medication. Your doctor and you will decide if the benefits outweigh the risk of using Epidiolex.

Epidiolex Usage

Epidiolex Overdose

If you take too much Epidiolex, call your healthcare provider or local Poison Control Center, or seek emergency medical attention right away.

Other Requirements

  • Store Epidiolex at room temperature room temperature between 68ºF to 77ºF (20ºC to 25ºC). Always store Epidiolex in its original bottle in an upright position. DO NOT refrigerate or freeze.
  • Use Epidiolex within 12 weeks of first opening the bottle. Throw away any unused medication after 12 weeks.
  • Keep this and all medicines out of the reach of children.

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