Dyazide

Dyazide treats high blood pressure and helps with fluid retention. This medication increases urination, so take it earlier in the day to avoid having to get up in the night to urinate.

Dyazide Overview

Reviewed: September 10, 2013
Updated: 

Dyazide is a prescription medication used to treat high blood pressure and edema (swelling). It is a single medication containing two drugs, triamterene and hydrochlorothiazide. Dyazide belong to a group of drugs called diuretics, which causes the kidneys to get rid of sodium and water while holding on to potassium.

This medication comes in capsule form and is taken once daily, with or without food.

Common side effects of Dyazide include frequent urination, weakness, fatigue, and headache.

Dyazide can cause dizziness. Do not drive or operate heavy machinery until you know how this medication affects you.

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Dyazide Cautionary Labels

precautionsprecautionsprecautionsprecautions

Uses of Dyazide

Dyazide is a prescription medication used to treat:

  • hypertension, or high blood pressure
  • edema, or fluid buildup in body tissue

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

Manufacturer

Dyazide Drug Class

Dyazide is part of the drug class:

Side Effects of Dyazide

Serious side effects have been reported with Dyazide. See “Drug Precautions” section.

Common side effects of Dyazide include:

  • frequent urination
  • headache
  • dizziness
  • weakness
  • dry mouth
  • fatigue

This is not a complete list of Dyazide side effects. Ask your doctor or pharmacist for more information.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Dyazide Interactions

Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you take:

  • thiazides, such as another medication containing hydrochlorothiazide (Microzide) or chlorothiazide (Diuril)
  • lithium
  • oral anti-diabetic drugs such as chlorpropamide (Diabinese), metformin (Glucophage), and pioglitazone (Actos)
  • non-steroidal anti-inflammatory drugs (NSAIDs) such as aspirin (Ecotrin), indomethacin (Indocin), and ibuprofen (Advil)
  • ACE inhibitors, such as enalapril (Vasotec) and lisinopril (Prinivil, Zestril)
  • other potassium-sparing medications, such as spironolactone (Aldactone) and amiloride (Midamor)
  • potassium supplements

This is not a complete list of Dyazide drug interactions. Ask your doctor or pharmacist for more information.

Dyazide Precautions

Serious side effects have been reported with triamterene/hydrochlorothiazide including:

  • Hyperkalemia: Dyazide can raise your body's potassium to harmful levels, possibly causing the heart to stop beating. Tell your doctor if you have kidney disease or diabetes.
  • Metabolic or respiratory acidosis: Dyazide can increase your potassium levels, leading to acidosis.
  • Myopia (nearsightedness) or glaucoma, or vision loss due to an increase in eye pressure: Tell your healthcare provider right away if you have some or all of the following symptoms of myopia or glaucoma:
    • sudden, severe pain in one eye
    • decreased or cloudy vision
    • nausea and vomiting
    • rainbow-like halos around lights
    • red eye
    • eye feels swollen
  • Electrolyte imbalances: Dyazide can dangerously alter your electrolyte levels. Electrolytes are important for the body to maintain normal functioning. Tell your doctor if you have a history of kidney disease.
  • Hepatic coma: Tell your doctor if you have a history of liver disease.
  • Renal stones: Treatment with Dyazide can cause kidney stones.
  • Hyperuricemia: Dyazide can increase your levels of uric acid, leading to gout. Symptoms of gout include:
    • pain
    • swelling
    • discolored, peeling, or itchy skin
  • Folic acid deficiency: Periodic blood tests are recommended for patients who may be affected by a decrease in folate levels.
  • Metabolic and endocrine effects: Dyazide can impair your body’s metabolism and endocrine system. Tell your doctor if you have diabetes or parathyroid problems.
  • Hypersensitivity reaction: An allergic reaction to Dyazide can occur. Call your doctor if you have one or more of the following symptoms of a hypersensitivity reaction:
    • rash or hives
    • difficulty breathing or swallowing
    • hoarseness
    • swelling

Dyazide can cause dizziness. Do not drive or operate heavy machinery until you know how it affects you.

Do not take Dyazide if you:

  • have high potassium levels
  • take other potassium-sparing medications such as spironolactone (Aldactone) and amiloride (Midamor)
  • take potassium supplements
  • have a history of poorly functioning kidneys
  • are allergic to either triamterene or hydrochlorothiazide

Dyazide Food Interactions

Medications can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of Dyazide, salt substitutes containing potassium should be avoided.

 

Inform MD

Before taking Dyazide, tell your doctor about all of your medical conditions. Especially tell your doctor if you:

  • have a history of kidney, liver, heart, or parathyroid disease
  • have diabetes
  • have high potassium levels
  • have a history of kidney stones, gout, or lupus
  • are allergic to triamterene or hydrochlorothiazide
  • have a history or glaucoma
  • are pregnant or breastfeeding

Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements.

Dyazide and Pregnancy

Tell your doctor if you are pregnant or plan to become pregnant.

The FDA categorizes medications based on safety for use during pregnancy. Five categories - A, B, C, D, and X, are used to classify the possible risks to an unborn baby when a medication is taken during pregnancy.

Dyazide falls into category C. This medication may be given to a pregnant woman if her healthcare provider believes that its benefits to the pregnant woman outweigh any possible risks to her unborn baby.

It is not known if Dyazide will harm your unborn baby.

Dyazide and Lactation

Tell your doctor if you are breastfeeding or plan to breastfeed.

You should not take Dyazide if you are breastfeeding. It may be excreted in your breast milk and may harm your nursing child.

Dyazide Usage

Take Dyazide exactly as prescribed.

This medication comes in capsule form and is taken once daily, with or without food.

If you miss a dose, take the missed dose as soon as you remember. If it is almost time for the next dose, skip the missed dose and take your next dose at the regular time. Do not take two doses of Dyazide at the same time.

 

Dyazide Dosage

Take Dyazide exactly as prescribed by your doctor. Follow the directions on your prescription label carefully.

Your doctor will prescribe the appropriate dosage depending on your condition and response to the medication. The dosages range from 37.5 to 75 mg (triamterene) and 25 to 50 mg (hydrochlorothiazide).

Dyazide Overdose

If you take too much Dyazide, call your healthcare provider or local Poison Control Center, or seek emergency medical attention right away.

 

Other Requirements

  • Store Dyazide at 20º to 25ºC (68º to 77ºF).
  • Keep this and all medicines out of the reach of children.

Dyazide FDA Warning

Abnormal elevation of serum potassium levels (greater than or equal to 5.5 mEq/liter) can occur with all potassium-sparing diuretic combinations, including Dyazide  capsules. Hyperkalemia is more likely to occur in patients with renal impairment and diabetes (even without evidence of renal impairment), and in the elderly or severely ill. Since uncorrected hyperkalemia may be fatal, serum potassium levels must be monitored at frequent intervals especially in patients first receiving Dyazide capsules, when dosages are changed or with any illness that may influence renal function.