A Study Evaluating the Efficacy and Safety of Idelalisib(GS-1101) in Combination With Bendamustine and Rituximab for Previously Treated Indolent Non-Hodgkin Lymphomas
Overview[ - collapse ][ - ]
| Purpose | The purpose of this study is to evaluate the effect of idelalisib (GS-1101) on the onset, magnitude, and duration of tumor control. |
|---|---|
| Condition | Indolent Non-Hodgkin's Lymphomas |
| Intervention | Drug: Idelalisib orally 150 mg BID Drug: Placebo orally 150 mg BID Drug: Rituximab IV 375 mg/m2 every 28 days for 4 cycles Drug: Bendamustine 90 mg/m2 for 2 consecutive days every 28 days for 4 cycles |
| Phase | Phase 3 |
| Sponsor | Gilead Sciences |
| Responsible Party | Gilead Sciences |
| ClinicalTrials.gov Identifier | NCT01732926 |
| First Received | November 14, 2012 |
| Last Updated | April 8, 2014 |
| Last verified | April 2014 |
Tracking Information[ + expand ][ + ]
| First Received Date | November 14, 2012 |
|---|---|
| Last Updated Date | April 8, 2014 |
| Start Date | January 2013 |
| Estimated Primary Completion Date | September 2022 |
| Current Primary Outcome Measures | Progression-free Survival [Time Frame: From randomization to 51 months] [Designated as safety issue: No]Progression-free survival is defined as the interval from randomization to the earlier of the first documentation of definitive iNHL disease progression or death from any cause. |
| Current Secondary Outcome Measures |
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Descriptive Information[ + expand ][ + ]
| Brief Title | A Study Evaluating the Efficacy and Safety of Idelalisib(GS-1101) in Combination With Bendamustine and Rituximab for Previously Treated Indolent Non-Hodgkin Lymphomas |
|---|---|
| Official Title | A Phase 3, Randomized, Double-Blind, Placebo Controlled Study Evaluating the Efficacy and Safety of Idelalisib (GS-1101) in Combination With Bendamustine and Rituximab for Previously Treated Indolent Non-Hodgkin Lymphomas |
| Brief Summary | The purpose of this study is to evaluate the effect of idelalisib (GS-1101) on the onset, magnitude, and duration of tumor control. |
| Detailed Description | This is a Phase 3, multicenter, 2-arm, randomized, double-blind, placebo-controlled clinical trial evaluating the efficacy and safety of the phosphatidylinositol 3-kinase delta (PI3K-delta) inhibitor idelalisib (GS-1101) in combination with bendamustine and rituximab for previously treated indolent non-Hodgkin lymphomas. Eligible subjects will be randomized with a 2:1 allocation to Arm A (idelalisib + bendamustine + rituximab) vs. Arm B (placebo + bendamustine + rituximab). |
| Study Type | Interventional |
| Study Phase | Phase 3 |
| Study Design | Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Treatment |
| Condition | Indolent Non-Hodgkin's Lymphomas |
| Intervention | Drug: Idelalisib orally 150 mg BID Other Names:
Drug: Rituximab IV 375 mg/m2 every 28 days for 4 cycles Drug: Bendamustine 90 mg/m2 for 2 consecutive days every 28 days for 4 cycles |
| Study Arm (s) |
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Recruitment Information[ + expand ][ + ]
| Recruitment Status | Recruiting |
|---|---|
| Estimated Enrollment | 450 |
| Estimated Completion Date | September 2022 |
| Estimated Primary Completion Date | September 2017 |
| Eligibility Criteria | Inclusion Criteria: - Histologically confirmed diagnosis of B-cell iNHL, with histological subtype limited to the following 1. Follicular lymphoma (FL) Grade 1, 2, or 3a 2. Small lymphocytic lymphoma (SLL) 3. Lymphoplasmacytoid lymphoma/Waldenström macroglobulinemia (LPL/WM) 4. Marginal zone lymphoma (MZL) (splenic, nodal, or extra-nodal) Exclusion Criteria: - Known histological transformation to an aggressive lymphoma - Ongoing drug-induced liver injury, active hepatitis C, active hepatitis B , alcoholic liver disease, non-alcoholic steatohepatitis, primary biliary cirrhosis, extrahepatic obstruction caused by cholelithiasis, cirrhosis of the liver, or portal hypertension. - Prior treatment with bendamustine that was not effective. |
| Gender | Both |
| Ages | 18 Years |
| Accepts Healthy Volunteers | No |
| Contacts | Contact: Meredith Cain Meredith.cain@gilead.com |
| Location Countries | United States, Australia, Canada, Czech Republic, France, Italy, Poland, Russian Federation, Spain, Sweden, United Kingdom |
Administrative Information[ + expand ][ + ]
| NCT Number | NCT01732926 |
|---|---|
| Other Study ID Numbers | GS-US-313-0125 |
| Has Data Monitoring Committee | Yes |
| Information Provided By | Gilead Sciences |
| Study Sponsor | Gilead Sciences |
| Collaborators | Not Provided |
| Investigators | Study Director: Steve Abella, MD Gilead Sciences |
| Verification Date | April 2014 |
Locations[ + expand ][ + ]
| Clearview Cancer Institute | Huntsville, Alabama, United States, 35805 Contact: Kathy Cutter | 256-705-4248 | kathyc@ccihsv.comPrincipal Investigator: Marshall Schreeder, M.D. Recruiting |
|---|---|
| Ironwood Cancer and Research Center | Chandler, Arizona, United States, 85224 Contact: Kimberly Palmreuter | 480-324-52622009 | kpalmreuter@ironwoodcrc.comPrincipal Investigator: Mikhail Shtivelband Recruiting |
| Comprehensive Blood and Cancer Center (Bakersfield) | Bakersfield, California, United States, 93309 Contact: Joy Moss | 661-862-7158 | jmoss@cbccusa.comPrincipal Investigator: David Kanamori, M.D. Recruiting |
| Providence Saint Joseph Medical Center-Disney Family Cancer Center | Burbank, California, United States, 91505 Withdrawn |
| California Cancer Associates for Research and Excellence (CCARE) | Fresno, California, United States, 93720 Contact: Cherra Brum | 559-326-1222272 | cbrum@ccare.comPrincipal Investigator: Steven Hager, MD Recruiting |
| Saint Jude Heritage Healthcare (TORI) | Fullerton, California, United States, 92835 Contact: Gayle Madden-Mathes | 714-446-5804 | gayle.madden-mathes@stjoe.orgPrincipal Investigator: William Lawler, M.D. Recruiting |
| Pacific Shores Medical Group | Long Beach, California, United States, 90813 Contact: Irene De Jesus | 562-590-0345 | irened@pacshoresoncology.comPrincipal Investigator: André Liem, M.D. Recruiting |
| UCLA Medical Center | Los Angeles, California, United States, 90095 Contact: Julie Rothermich | 310-633-8400 | jrothermich@mednet.ucla.eduPrincipal Investigator: Sven De Vos Recruiting |
| Cancer Care Associates | Redondo Beach, California, United States, 90277 Contact: Sherry Hutcherson | 310-750-3376 | shutcherson@mednet.ucla.eduPrincipal Investigator: Hugo Hool, M.D. Recruiting |
| Cancer Center of Santa Barbara | Santa Barbara, California, United States, 93105 Contact: Megan Wingo | 805-898-1335 | meganw@ccsb.orgPrincipal Investigator: Daniel Greenwald, M.D. Recruiting |
| Coastal Integrative Cancer Care | Santa Maria, California, United States, 93454 Contact: Jessica Free | 805-543-5577 | jfree@ohmacc.comPrincipal Investigator: Brian DiCarlo, M.D. Recruiting |
| Central Coast Medical Oncology Group | Santa Maria, California, United States, 93454 Contact: Maria Mejia | 805-346-3466 | mariamejia@mednet.ucla.eduPrincipal Investigator: Robert Dichmann, M.D. Recruiting |
| Redwood Regional Oncology Group | Santa Rosa, California, United States, 95403 Contact: Teresa Lund | 707-521-3803 | tlund@rrmg.comPrincipal Investigator: Jarrod Holmes, M.D. Recruiting |
| Stanford University Medical Center | Stanford, California, United States, 94304 Contact: Rana Fiaz | 650-723-0670 | rfiaz@stanford.eduPrincipal Investigator: Holbrook Kohrt, MD Recruiting |
| Middlesex Hospital Cancer Center | Middletown, Connecticut, United States, 06457 Contact: Camille Servodidio | 860-358-2085 | camille.servodidio@midhosp.orgPrincipal Investigator: Robert Levy, M.D. Recruiting |
| Stamford Hospital | Stamford, Connecticut, United States, 06902 Contact: Susan Murdock | 203-276-8453 | smurdock@stamhealth.orgPrincipal Investigator: Anne Angevine Recruiting |
| Collaborative Research Group, LLC | Boynton Beach, Florida, United States, 33435 Active, not recruiting |
| Florida Cancer Specialists | Brooksville, Florida, United States, 34613 Contact: Kim Graves | 352-596-1401218 | kgraves@flcancer.comPrincipal Investigator: Raju Rao, MD Recruiting |
| Cancer Care of North Florida | Jacksonville, Florida, United States, 32256 Contact: Edrelyn Rosario | 904-739-4847 | edrelyn.rosario@cancerspecialistsnf.comPrincipal Investigator: Mehdi Moezi, M.D. Recruiting |
| Cancer and Blood Disease Center | Lecanto, Florida, United States, 34462 Contact: Linda Kruleski | 352-746-0707 | lktrials@tampabay.rr.comPrincipal Investigator: Gustavo Fonseca Recruiting |
| Sylvester Comprehensive Cancer Center/UMHC | Miami, Florida, United States, 33442 Contact: Donna Mitchell | 954-698-3673 | d.mitchell6@med.miami.eduPrincipal Investigator: Israel Wiznitzer, MD Recruiting |
| ICON Oncology | Orange Park, Florida, United States, 32073 Contact: Carla Malott | 904-276-2303 | cmalott@icononcology.comPrincipal Investigator: Linda Sylvester, MD Recruiting |
| Eisenhower Army Medical Center | Fort Gordon, Georgia, United States, 30905 Contact: Susan Rogers | 706-787-2100 | susan.d.rogers.civ@mail.milPrincipal Investigator: Jason Burris, MD Recruiting |
| Northwest Georgia Oncology Centers, PC | Marietta, Georgia, United States, 30060 Contact: Mary Gilley | 770-281-5131 | mgilley@ngoc.comPrincipal Investigator: Robert Hermann, M.D. Recruiting |
| Rush University Medical Center | Chicago, Illinois, United States, 60612 Contact: Linda Pierchala | 312-942-3327 | linda_pierchala@rush.eduPrincipal Investigator: Parameswaran Venugopal, MD Recruiting |
| Medical and Surgical Specialists, LLC | Galesburg, Illinois, United States, 61401 Withdrawn |
| Joliet Oncology Hematology Associates Ltd. | Joliet, Illinois, United States, 60435 Contact: Karen Sceniak | 815-730-3098 | ksceniak@jolietoncology.comPrincipal Investigator: Kulumani Sivarajan, M.D. Recruiting |
| Illinois Cancer Specialists | Niles, Illinois, United States, 60714 Contact: Lisbeth Lynn | 847-827-9060 | lisbeth.lynn@usoncology.comPrincipal Investigator: Leonard Klein, M.D. Recruiting |
| Cancer Center of Kansas | Wichita, Kansas, United States, 67214 Contact: Renee Schott | 316-613-4314 | renee.schott@cancercenterofkansas.comPrincipal Investigator: Shaker Dakhil, M.D. Recruiting |
| Montgomery Cancer Center | Mount Sterling, Kentucky, United States, 40353 Contact: Kristen Wilson | 859-499-1000 | kjwilson_mcc@hotmail.comPrincipal Investigator: Muhammad-Ali Zaydan, MD Recruiting |
| Center for Cancer and Blood Disorders, PC | Bethesda, Maryland, United States, 20817 Contact: Christine DiSilvestre | 240-482-0535 | cdisilvestre@ccbdmd.comPrincipal Investigator: Ralph Boccia, M.D. Recruiting |
| Maryland Oncology Hematology, P.A. | Columbia, Maryland, United States, 21044 Active, not recruiting |
| Dana-Farber Cancer Institute | Boston, Massachusetts, United States, 02215 Contact: Leslie Cowen | 617-582-7292 | leslief_cowen@dfci.harvard.eduPrincipal Investigator: Caron Jacobson, MD Recruiting |
| West Michigan Cancer Center | Kalamazoo, Michigan, United States, 49007 Contact: Zelda Smith | 269-373-7447 | zsmith@wmcc.orgPrincipal Investigator: Raymond Lord, III, M.D. FACP Recruiting |
| Jackson Oncology Associates, PLLC | Jackson, Mississippi, United States, 39202 Contact: Teresa Davis | 601-974-5547 | teresadavis@mbhs.orgPrincipal Investigator: Grace Shumaker, M.D. Recruiting |
| University of Medicine and Dentistry of New Jersey | New Brunswick, New Jersey, United States, 08903 Contact: Poonam Pandit | 212-263-4424 | pp518@cinj.rutgers.eduPrincipal Investigator: Kevin David, MD Recruiting |
| Roswell Park Cancer Institute | Buffalo, New York, United States, 14263 Contact: Theresa Hodin | 716-845-4485 | theresa.hodin@roswellpark.orgPrincipal Investigator: Myron Czuczman Recruiting |
| North Shore Hematology/Oncolocy Associates | East Setauket, New York, United States, 11733 Contact: Loretta Pierzchanowski | 631-675-5170 | lpierzch@nshoa.comPrincipal Investigator: Jeffrey Vacirca, MD Recruiting |
| Weill Cornell Medical College | New York, New York, United States, 10002 Contact: James McConnell | 212-746-2652 | jam2064@med.cornell.edPrincipal Investigator: Peter Martin, MD Recruiting |
| Cornerstone Hematology/Oncology | High Point, North Carolina, United States, 27262 Contact: Jo Thomas | 336-802-2682 | jo.thomas@cornerstonehealthcare.comPrincipal Investigator: Vallathucherry Harish, M.D. Recruiting |
| Signal Point Clinical Research Center, LLC | Middletown, Ohio, United States, 45042 Contact: Kendra Rutschilling | 513-423-0504 | kendrar@swohio.twcbc.comPrincipal Investigator: Nandagopal Vrindavanam, M.D. Recruiting |
| Hollings Cancer Center | Charleston, South Carolina, United States, 29425 Contact: Shanta Salzer | 843-792-1463 | salzers@musc.eduPrincipal Investigator: Luciano Costa, MD Recruiting |
| Bon Secours Saint Francis Hospital | Greenville, South Carolina, United States, 29601 Contact: Kristina Stoeppler-Biege | 864-255-1517 | kristina_stoeppler-biege@bshsi.orgPrincipal Investigator: Gary Spitzer Recruiting |
| Prairie Lakes Healthcare System | Watertown, South Dakota, United States, 57252 Contact: Lisa Campbell | 605-882-6800 | lisa.campbell@prairielakes.comPrincipal Investigator: Bipinkumar Amin, M.D. Recruiting |
| Wellmont Bristol Regional Medical Center | Bristol, Tennessee, United States, 37620 Contact: Tracy Bowman | 423-968-2311 | tracy.bowman@wellmont.orgPrincipal Investigator: Sue Prill, M.D. Recruiting |
| Texas Oncology, P.A. | Bedford, Texas, United States, 76022 Contact: Sandy Mathews | 817-359-9033 | sandy.mathews@usoncology.comPrincipal Investigator: Thomas Anderson, MD Recruiting |
| Charles A. Sammons Cancer Center | Dallas, Texas, United States, 75246 Contact: Nancy Ryan | 214-820-6967 | nancyry@baylorhealth.eduPrincipal Investigator: Barry Cooper, M.D. Recruiting |
| Texas Oncology, P.A. | Denton, Texas, United States, 76210 Contact: Elle Boleware | 940-380-7952 | elle.boleware@usoncology.comPrincipal Investigator: Sharad Jain, MD Recruiting |
| Texas Oncology, P.A. | Flower Mound, Texas, United States, 75028 Contact: Esperanza Jackson | 940-380-7952 | esperanza.jackson@usoncology.comPrincipal Investigator: Derrick Nguyen, MD Recruiting |
| Brooke Army Medical Center | Fort Sam Houston, Texas, United States, 78234 Contact: Peggy Smith | 210-916-3332 | peggy.s.smith56.ctr@mail.milPrincipal Investigator: Alexander Brown Recruiting |
| Texas Oncology, P.A. | Fort Worth, Texas, United States, 76104 Contact: Nori Sullivan | 817-850-2010 | nori.sullivan@usoncology.comPrincipal Investigator: Robert Ruxer, Jr., MD Recruiting |
| Texas Oncology, P.A. | Mesquite, Texas, United States, 75150 Contact: Christie Stixrud | 214-939-7837 | christe.stixrud@usoncology.comPrincipal Investigator: Sreeni Chittoor, MD Recruiting |
| Utah Cancer Specialists | Salt Lake City, Utah, United States, 84106 Contact: Sylvia Lewis | 801-281-6863 | slewis@utahcancer.comPrincipal Investigator: W. Graydon Harker Recruiting |
| Shenandoah Oncology Associates, PC | Winchester, Virginia, United States, 22601 Contact: Claudia Phillips | 540-662-1108 | claudia.phillips@usoncology.comPrincipal Investigator: William Houck, III, MD Recruiting |
| Swedish Medical Center | Seattle, Washington, United States, 98104 Contact: Cara Wiseman | 206-386-2301 | cara.wiseman@swedish.orgPrincipal Investigator: Michael Milder, M.D. Recruiting |
| Northwest Medical Specialists | Tacoma, Washington, United States, 98405 Contact: Debi Kadoun | 253-396-5334 | dkadoun@nwmsonline.comPrincipal Investigator: Moacyr de Oliveira, M.D. Recruiting |
| Froedtert Hospital and Medical College of Wisconsin | Milwaukee, Wisconsin, United States, 53226 Contact: Arielle Baim | 414-805-8745 | abaim@mcw.eduPrincipal Investigator: Timothy Fenske, MD Recruiting |
| Prince of Wales Hospital | Randwick, New South Wales, Australia, 2031 Contact: Karen McCardie | +61293829049 | karen.mccardie@sesiahs.health.nsw.gov.auPrincipal Investigator: Robert Lindeman, MD Recruiting |
| Haematology and Oncology Clinics of Australia Gold Coast | South Brisbane, Queensland, Australia, 4101 Contact: Matthew Cook | +61737374750 | mcook@hoca.com.auPrincipal Investigator: Kerry Taylor Recruiting |
| Royal Adelaide Hospital | Adelaide, South Australia, Australia, 5000 Contact: Menguin Zhu | +0882223368 | mengjun.zhu@health.sa.gov.auPrincipal Investigator: Pratyush Giri Recruiting |
| Adelaide Cancer Centre | Kurralta Park, South Australia, Australia, 5037 Contact: Helen Daykin | +61882922240 | hdaykin@adelaidecancercentre.com.auPrincipal Investigator: Shriram Nath Recruiting |
| Box Hill Hospital | Box Hill, Victoria, Australia, 3128 Contact: Yvonne Chan | +61398953203 | yvonne.chan@easternhealth.org.auPrincipal Investigator: Joseph McKendrick, MD Recruiting |
| Monash Medical Centre | Clayton, Victoria, Australia, 3168 Contact: Cheryl Coleman | +61395944044 | cheryl.coleman@southernhealth.org.auPrincipal Investigator: Stephen Opat, MD Recruiting |
| Saint Vincent's Hospital | Fitzroy, Victoria, Australia, 3065 Contact: Amber Degelia | +61392883168 | amber.degelia@svhm.org.auPrincipal Investigator: Ali Bazargan Recruiting |
| Western Hospital | Footscray, Victoria, Australia, 3011 Contact: Shannon Uren | +0383457607 | shannon.uren@wh.org.auPrincipal Investigator: William Renwick Recruiting |
| Royal Perth Hospital | Perth, Western Australia, Australia, 6000 Contact: Megan Margaria | +61892247038 | megan.margaria@health.wa.gov.auPrincipal Investigator: Paul Cannell Recruiting |
| Tom Baker Cancer Center | Calgary, Alberta, Canada, T2N 2T9 Contact: Kelly Mclachlan | 1 (403) 521-3383 | kelly.mclachlan@albertahealthservices.caPrincipal Investigator: Douglas Stewart Recruiting |
| Cross Cancer Institute | Edmonton, Alberta, Canada, T6G 1Z2 Contact: Trish Merrick | 1 (780) 989-8156 | trish.merrick@albertahealthservices.caPrincipal Investigator: Neil Chua, MD Recruiting |
| Fraser Clinical Trials, Inc. | New Westminster, British Columbia, Canada, V3L 3W4 Contact: Carol Marchand | 1 (604) 521-4500 | cmarchand@fct05.comPrincipal Investigator: Michael Noble Recruiting |
| BC Cancer Agency - Vancouver Centre | Vancouver, British Columbia, Canada, V5Z 4E6 Contact: Elena Moon | 1 (604) 707-5987 | emoon@bccancer.bc.caPrincipal Investigator: Laurie Sehn Recruiting |
| CancerCare Manitoba | Winnipeg, Manitoba, Canada, R3E 0V9 Contact: Darlene Zwarych | 1 (204) 787-8805 | darlene.zwarych@cancercare.mb.caPrincipal Investigator: Pamela Skrabek Recruiting |
| Queen Elizabeth II Health Sciences Centre, Centre for Clinical Research | Halifax, Nova Scotia, Canada, B3H 1V7 Contact: Valerie Dorcas | 1 (902) 473-4009 | valerie.dorcas@cdha.nshealth.caPrincipal Investigator: David MacDonald Recruiting |
| Royal Victoria Regional Health Centre | Barrie, Ontario, Canada, L4M 6M2 Contact: Kim Marsh-Gray | 1 (705) 728-909043340Principal Investigator: Derek Nay Recruiting |
| Sunnybrook Health Sciences Centre | Toronto, Ontario, Canada, M4N 3M5 Contact: Geetha Yogendran | 1 (416) 480-6100 ext: 89565 | geetha.yogendran@sunnybrook.caPrincipal Investigator: Matthew Cheung Recruiting |
| Centre Hospitalier Universitaire de Sherbrooke | Sherbrooke, Quebec, Canada, J1H 5N4 Contact: Anick Champoux | 1 (819) 346-111012811 | achampoux.chus@ssss.gouv.qc.caPrincipal Investigator: Hans Knecht Recruiting |
| Centre Hospitalier Affilie Universitaire de Quebec | Quebec, Canada, G1J 1Z4 Contact: Yolaine Hebert | 1 (418) 649-02525865 | yolaine.hébert.cha@ssss.gouv.qc.caPrincipal Investigator: Jean-François Larouche Recruiting |
| Fakultní Nemocnice Ostrava | Ostrava - Poruba, Severomoravsky Kraj, Czech Republic, 708 52 Contact: Martina Januskova | +420605586959 | martina.januskova@fno.czPrincipal Investigator: Roman Hájek Recruiting |
| Fakultní nemocnice Brno | Brno, Czech Republic, 625 00 Contact: Emilie Nováková | +420532233552 | enovakova@fnbrno.czPrincipal Investigator: Jiri Mayer Recruiting |
| Fakultní nemocnice Hradec Králové | Hradec Králové, Czech Republic, 500 05 Contact: Martina Havlícková | +420495834593 | martina.havlickova1@gmail.comPrincipal Investigator: David Belada Recruiting |
| CHR Metz | Metz Cedex 03, Alsace, France, 57085 Contact: Catherine Fery | +33387179885 | c.fery@chr-metz-thionville.frPrincipal Investigator: Alina Zamfir Recruiting |
| Institut Bergonié | Bordeaux Cedex, Aquitaine, France, 33076 Contact: Manuella Sombo | +33547306054 | m.sombo@bordeaux.unicancer.frPrincipal Investigator: Anna Schmitt Recruiting |
| Polyclinique de Bordeaux-Nord | Bordeaux Cedex, Aquitaine, France, 33077 Contact: Sandrine Hirt | +33556437073 | s.hirt@bordeauxnord.comPrincipal Investigator: Olivier Fitoussi Recruiting |
| Centre Henri-Becquerel | Rouen Cedex 1, Haute-normandie, France, 76038 Contact: Laure Gaillon | +33232082220 | laure.ditullio-gaillon@chb.unicancer.frPrincipal Investigator: Herve Tilly Recruiting |
| Hôpital Necker-Enfants Malades | Paris, Ile-de-france, France, 75015 Contact: Gaelle Fanet | +33144494657 | gaelle.fanet@nck.aphp.frPrincipal Investigator: Richard Delarue Recruiting |
| Hôpital Caremeau | Nîmes Cedex 9, Languedoc-roussillon, France, 30029 Contact: Rima Benmahdi | +33466683678 | rima.benmahdi@chu-nimes.frPrincipal Investigator: Eric Jourdan Recruiting |
| Centre Jean Bernard | Le Mans, Pays de La Loire, France, 72000 Contact: Anne Malhaire | +33243297988 | amalhaire_sorecoh@yahoo.frPrincipal Investigator: Katell Le Dû Recruiting |
| Centre Hospitalier Universitaire de Grenoble | La Tronche, Rhone-alpes, France, 38700 Contact: Ghislain Yrika | +33476769241 | gyirika@chu-grenoble.frPrincipal Investigator: Rémy Gressin Recruiting |
| Centre Hospitalier Lyon Sud | Pierre Bénite Cedex, Rhone-alpes, France, 69495 Contact: Samuel Moullé | +33478861203 | samuel.moulle@chu-lyon.frPrincipal Investigator: Gilles Salles, MD, PhD Recruiting |
| Centre Hospitalier Universitaire Brest | Brest Cedex, France, 29609 Contact: Dominique Gillet | +33298223245 | dominique.gillet@chu-brest.frPrincipal Investigator: Adrian Tempescul Recruiting |
| Centre Hospitalier de Dunkerque | Dunkerque, France, 59385 Contact: Virginie Paquez | +33228285633 | virginie.paquez@ch-dunkerque.frPrincipal Investigator: Jean-Michel Pignon Recruiting |
| Centre Hospitalier Départmental La Roche sur Yon | La Roche sur Yon, France, 85925 Contact: Hélène Renoul | +33251446467 | helene.renoul@chd-vendee.frPrincipal Investigator: Hervé Maisonneuve Recruiting |
| Centre Hospitalier de Versailles | Le Chesnay, France, 78157 Contact: Mélody Fort | +33139239783 | mfort@ch-versailles.frPrincipal Investigator: Stéphanie Ghez Recruiting |
| Centre Léon Bérard | Lyon Cedex 08, France, 69373 Contact: Sarah Younsi-Le Bivic | +33478782862Principal Investigator: Catherine Sebban Recruiting |
| Centre Hospitalier Universitaire de Poitiers | Poitiers Cedex, France, 86000 Contact: Alice Langlois | +33549443084 | alice.langlois@chu-poitiers.frPrincipal Investigator: Vincent Delwail Recruiting |
| Centre Hospitalier Régional et Universitaire - Hôpital Bretonneau | Tours, France, 37044 Contact: Sabrina Leclercq | +330240083270 | s.leclercq@chu-tours.frPrincipal Investigator: Emmanuel Gyan, MD, PhD Recruiting |
| Centro di Riferimento Oncologico di Aviano | Aviano, Italy, 33081 Contact: Elena Ravaioli | +390434659078 | eravaioli@cro.itPrincipal Investigator: Michele Spina Recruiting |
| Ospedale San Raffaele-IRCCS | Milano, Italy, 20132 Contact: Nunzia Orsino | +390226433919 | orsino.nunzia@hsr.itPrincipal Investigator: Andres Ferreri Recruiting |
| Azienda Ospedaliero Universitaria (AOU) "Maggiore della Carita" di Novara | Novara, Italy, 28100 Contact: Clara Deambrogi | +3903213732194 | clara.deambrogi@med.unipmn.itPrincipal Investigator: Gianluca Gaidano Recruiting |
| Azienda Ospedaliera Ospedali Riuniti Marche Nord | Pesaro, Italy, 61100 Contact: Teresa Ricciardi | +390721364022 | teresaricciardi85@gmail.comPrincipal Investigator: Giuseppe Visani Recruiting |
| Azienda Unità Sanitaria Locale di Piacenza-Ospedale Guglielmo da Saliceto | Piacenza, Italy, 29100 Contact: Vanessa Valenti | +390523303731 | valenti_vanessa@libero.itPrincipal Investigator: Daniele Vallisa Recruiting |
| Azienda Ospedaliera Città della Salute e della Scienza di Torino | Torino, Italy, 10126 Contact: Giorgio Priolo | +390116335611 | gpriolo2@cittadellasalute.to.itPrincipal Investigator: Umberto Vitolo Recruiting |
| Uniwersyteckie Centrum Kliniczne | Gdansk, Poland, 80-952 Contact: Gabriela Jadowska | +48583492230 | gjadowska@uck.gda.plPrincipal Investigator: Andrzej Hellmann Recruiting |
| Malopolskie Centrum Medyczne S.C. | Kraków, Poland, 30-510 Contact: Bozena Jachimczak | +48122954136 | mcm.bozena.jachimczak@mp.plPrincipal Investigator: Wojciech Jurczak Recruiting |
| Szpital Kliniczny nr 1, Katedra i Klinika Hematoonkologii i Transplantacji Szpiku | Lublin, Poland, 20-081 Contact: Olga Jankowska | +48691722991 | olga.jank@wp.plPrincipal Investigator: Marek Hus Recruiting |
| Wojewódzki Szpital Specjalistyczny im. Mikolaja Kopernika w Lodzi | Lódz, Poland, 93-510 Contact: Lucyna Rolczak | +48426895486 | lucyna.rolczak@wp.plPrincipal Investigator: Tadeusz Robak Recruiting |
| Samodzielny Publiczny Zaklad Opieki Zdrowotnej Ministerstwa Spraw Wewnetrznych z Warminsko-Mazurskim | Olsztyn, Poland, 10-228 Contact: Agnieszka Ornatowska | +48895398757 | agnieszka.ornatowska@poliklinika.netPrincipal Investigator: Wanda Knopinska-Posluszny Recruiting |
| Wojewódzki Szpital Specjalistyczny im. Janusza Korczaka w Slupsku | Slupsk, Poland, 76-200 Contact: Pierzchalska Magda | +48598460350 | magda.pierzchalska@wp.plPrincipal Investigator: Wojciech Homenda Recruiting |
| Instytut Hematologii i Transfuzjologii | Warszawa, Poland, 02-776 Contact: Malgorzata Makowska | +48223496468 | mmakowska@ihit.waw.plPrincipal Investigator: Ewa Lech-Maranda Recruiting |
| Centrum Onkologii i Hipertermii | Warszawa, Poland, 02-781 Contact: Jolanta Stawska | +48225462223 | jola@coi.waw.plPrincipal Investigator: Jan Walewski Recruiting |
| Central City Hospital # 7 | Ekaterinburg, Russian Federation, 620137 Contact: Viacheslav Semenov | +73433417571 | semen@cgb7.ruPrincipal Investigator: Alexander Loginov Recruiting |
| Sverdlovsk Regional Clinical Hospital #1 | Ekaterinburg, Russian Federation, 620102 Contact: Elena Pereginec | +73433511653 | e.v.pereginec@okb1.ruPrincipal Investigator: Tatyana Konstantinova Recruiting |
| N. N. Blokhin Russian Cancer Research Center | Moscow, Russian Federation, 115478 Contact: Evgenia Skvortsova | +74953249829 | evgesha0305@rambler.ruPrincipal Investigator: Dzhelil Osmanov Recruiting |
| Nizhny Novgorod Regional Clinical Hospital n.a. N.A. Semashko | Nizhniy Novgorod, Russian Federation, 603126 Contact: Larisa Samodelkina | +78314389519 | l.samodelkina@mail.ruPrincipal Investigator: Olga Samoilova Recruiting |
| Ryazan Regional Clinical Hospital | Ryazan, Russian Federation, 390039 Contact: Alexey Shaposhnikov | +74912363998 | super.alex1976@mail.ruPrincipal Investigator: Alexander Pristupa Recruiting |
| FSI "V.A. Almazov Federal Centre of Heart, Blood and Endocrinology of Rosmedtechnologies" | Saint Petersburg, Russian Federation, 197341 Contact: Irina Shakhomirova | +78127023765 | irina.shakhomirova@yandex.ruPrincipal Investigator: Andrey Zaritskiy Recruiting |
| State Educational Institution "S.M. Kirov Military Medical Academy of Ministry of Defense of Russia" | Saint Petersburg, Russian Federation, 194044 Contact: Sergey Bondarchuk | +79119552188 | dokbond@mail.ruPrincipal Investigator: Andrey Maximov Recruiting |
| FGU Russian Scientific Research Institute of Hematology and Transfusiology | Saint Petersburg, Russian Federation, 191024 Contact: Aleksei Kuvshinov | +78122743770 | xupypr83@mail.ruPrincipal Investigator: Kudrat Abdulkadyrov Recruiting |
| Saint Petersburg I.P. Pavlov State Medical University | Saint-Petersburg, Russian Federation, 197022 Contact: Natalia Mikhaylova | +78122332806 | bmt.lymphoma@gmail.comPrincipal Investigator: Boris Afanasiev Recruiting |
| Saratov State Medical University | Saratov, Russian Federation, 410 028 Contact: Varvara Bogova | +78452202294 | bogova82@mail.ruPrincipal Investigator: Tatiana Shelekhova Recruiting |
| State Healthcare Institution "Oncologic Dispensary #2" of Public Health Department of Krasnodar Region | Sochi, Russian Federation, 354057 Contact: Natalia Shapovalova | +78622614089 | sochitrials@gmail.comPrincipal Investigator: Dmitriy Udovitsa Recruiting |
| State Budgetary Healthcare Institution "Volgograd Regional Clinical Oncology Dispensary #1" | Volgograd, Russian Federation, 400138 Contact: Anna Shipaeva | +78442585219 | annahem@mail.ruPrincipal Investigator: Kamil Kaplanov Recruiting |
| Hospital Universitario Puerta de Hierro | Majadahonda, Madrid, Spain, 28222 Contact: Amaya Echave | +34911917913 | aechave.huph@gmail.comPrincipal Investigator: Jose Garcia-Marco Recruiting |
| Hospital de Navarra | Pamplona, Navarra, Spain, 31008 Contact: Ana Silva | +34848428428 | ak.silva.soto@navarra.esPrincipal Investigator: Eduardo Olavarria Recruiting |
| Hospital Universitari Germans Trias i Pujol | Badalona, Spain, 08916 Contact: Luz San Miguel | +349346512003546 | luzsanmiguel@hotmail.comPrincipal Investigator: Juan Manuel Sancho Recruiting |
| Hospital Universitario 12 de Octubre | Madrid, Spain, 28041 Contact: Pilar Portsany | +34913908525 | pilar.portasany@gmail.comPrincipal Investigator: Carlos Grande García Recruiting |
| Hospital Universitario La Princesa | Madrid, Spain, 28006 Contact: Sofia Escalona | +3491520220012212 | sofias230903@gmail.comPrincipal Investigator: Reyes Arranz Recruiting |
| Hospital General Universitario Gregorio Marañon | Madrid, Spain, 28009 Contact: Cristina Muñoz | +34915868394 | cmunozm.hgugm@salud.madrid.orgPrincipal Investigator: Patricia Font López Recruiting |
| Clínica Universitaria de Navarra | Pamplona, Spain, 31008 Contact: Miren Remon | +34948296397 | mremon@unav.esPrincipal Investigator: Carlos Panizo Santos Recruiting |
| Hospital Universitario de Canarias | San Cristobal de La Laguna, Spain, 38320 Contact: Cornelia Stoica | +34922678207Principal Investigator: Mª José Rodríguez Salazar Recruiting |
| Hospital Universitario Virgen del Rocio | Sevilla, Spain, 41013 Contact: Rocio Jiménez | +3495501325859 | rociojimenezalvarez@gmail.comPrincipal Investigator: Estrella Carrillo Cruz Recruiting |
| Hospital Universitari i Politecnic La Fé de Valencia | Valencia, Spain, 46026 Contact: Aurora Perla | +34961244190 | perla_aur@gva.esPrincipal Investigator: Isidro Jarque Recruiting |
| Länssjukhuset Ryhov | Jönköping, Sweden, 551 85 Contact: Bo Thelin | +46036325943 | bo.thelin@lj.sePrincipal Investigator: Anders Rådlund Recruiting |
| Karolinska University Hospital Huddinge | Stockholm, Sweden, 141 86 Contact: Kristina Kinneholm | +460858586855 | kristina.kinneholm@karolinska.sePrincipal Investigator: Björn Wahlin Recruiting |
| Kent and Canterbury Hospital | Canterbury, England, United Kingdom, CT1 3NG Contact: Lavinia Parsons | +4401227864129 | lavinia.parsons@nhs.netPrincipal Investigator: Christopher Pocock Recruiting |
| University Hospital Coventry | Coventry, England, United Kingdom, CV2 2DX Contact: Kimberley White | +4402476967151 | kimberley.white@uhcw.nhs.ukPrincipal Investigator: Beth Harrison Recruiting |
| Royal Bournemouth General Hospital | Dorset, England, United Kingdom, BH7 7DW Contact: Emma Tilt | +4401202726246 | emma.tilt@rbch.nhs.ukPrincipal Investigator: Renata Walewska Recruiting |
| Leeds Teaching Hospitals NHS Trust | Leeds, England, United Kingdom, LS9 7TF Contact: Lauren Birkinshaw | +01132068577 | lauren.birkinshaw@leedsth.nhs.ukPrincipal Investigator: Roderick Johnson Recruiting |
| Imperial College Healthcare NHS Trust | London, England, United Kingdom, W12 0HS Contact: Christos Paliompeis | +4402033134715 | c.paliompeis@imperial.ac.ukPrincipal Investigator: Anastasios Karadimitris Recruiting |
| Sarah Cannon Research Institute | London, England, United Kingdom, W1G 6AD Contact: Zsuzsa Michnai | +442032195200 | zsuzsa.michnai@hcahealthcare.co.ukare.co.ukPrincipal Investigator: Tobias Arkenau Recruiting |
| University College London Hospitals National Health Society Foundation Trust | London, England, United Kingdom, NW1 2PG Contact: Miranda Avery | +4402034478687 | miranda.avery@uclh.nhs.ukPrincipal Investigator: Kirit Ardeshna Recruiting |
| Guys and Saint Thomas NHS Foundation Trust | London, England, United Kingdom, SE1 9RT Contact: Claire Woodley | +440207188718851152 | claire.woodley@gstt.nhs.ukPrincipal Investigator: David Wrench Recruiting |
| Barts and The London NHS Trust | London, England, United Kingdom, EC1A 7BE Contact: Lola Famakinwa | +4402034655077 | lola.famakinwa@bartshealth.nhs.ukPrincipal Investigator: Rebecca Auer Recruiting |
| Maidstone Hospital | Maidstone, England, United Kingdom, ME16 9QQ Contact: Victoria Ingleson | +4401622227088 | victoria.ingleson@nhs.netPrincipal Investigator: Saad Rassam Recruiting |
| Christie Hospital NHS Foundation Trust | Manchester, England, United Kingdom, M20 4BX Contact: Cathy Spence | +4401619187964 | cathy.spence@christie.nhs.ukPrincipal Investigator: Kim Linton Recruiting |
| Royal Oldham Hospital | Oldham, England, United Kingdom, OL1 2JH Contact: Richard Jones | +4401616278165 | richard.jones@pat.nhs.ukPrincipal Investigator: Martin Rowlands Recruiting |
| Oxford University Hospitals NHS Trust | Oxford, England, United Kingdom, OX3 7LE Contact: Chris Levett | +4401865243232 | christopher.levett@ouh.nhs.ukPrincipal Investigator: Graham Collins Recruiting |
| Southampton General Hospital | Southampton, England, United Kingdom, SO16 6YD Contact: Samantha Chilton | +4402380796113 | s.chilton@southampton.ac.ukPrincipal Investigator: Andrew J. Davies Recruiting |
| Mount Vernon Hospital | Middlesex, United Kingdom, HA6 2RN Contact: Charina Ocampo | +4401923844982 | charina.ocampo@nhs.netPrincipal Investigator: Peter Hoskin Recruiting |
| Sunderland Royal Infirmary | Sunderland, United Kingdom, SR4 7TP Contact: Jane Cole | +0191565625647264 | jane.cole6@nhs.netPrincipal Investigator: Scott Marshall Recruiting |
| New Cross Hospital | Wolverhampton, United Kingdom, WV10 0QP Contact: Claire Beardsmore | +4401902694430 | claire.beardsmore@nhs.netPrincipal Investigator: Abraham Jacob Recruiting |