Cinvanti

Cinvanti is used to prevent nausea and vomiting associated with cancer chemotherapy. Cinvanti is taken on Day 1 of chemotherapy.

Cinvanti Overview

Reviewed: November 21, 2017
Updated: 

Cinvanti is a prescription medication used to prevent nausea and vomiting that may occur after receiving chemotherapy treatment. It is typically used with other medications that help relieve nausea and vomiting. Cinvanti belongs to a group of drugs called antiemetics. These work by blocking the action of neurokinin, a natural substance in the brain that causes nausea and vomiting.

This medication is available in an injectable form to be given directly into a vein (IV) by a healthcare professional on day 1 of chemotherapy.

Common side effects of Cinvanti include tiredness, burping, and headache. Do not drive or operate heavy machinery until you know how Civanti affects you.

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Cinvanti Cautionary Labels

precautionsprecautions

Uses of Cinvanti

Cinvanti is a prescription medication used to prevent nausea and vomiting that may occur after receiving chemotherapy treatment. Cinvanti can prevent nausea and vomiting that may occur within 24 hours and within several days after receiving chemotherapy medications. It is typically used with other medications.

Cinvanti is not used to treat nausea and vomiting that you already have.

Cinvanti should not be used continuously for a long time (chronic use).

It is not known if Cinvanti is safe and effective in children.

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

Cinvanti Drug Class

Cinvanti is part of the drug class:

Side Effects of Cinvanti

Serious side effects have been reported with Cinvanti. See the “Cinvanti Precautions” section.

Common side effects of Cinvanti include the following:

  • tiredness
  • burping or belching
  • reation at the infusion site
  • headache

This is not a complete list of Cinvanti side effects. Ask your doctor or pharmacist for more information.

Tell your doctor if you have any side effects that bother you or that do not go away.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Cinvanti Interactions

Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you take:

  • pimozide
  • warfarin
  • hormonal contraceptives such as oral birth control, skin patches, implants, and certain IUDs
  • corticosteroids such as dexamethasone or methylprednisolone
  • benzodiazepines such as midazolam, alprazolam, or triazolam
  • other antiemetic agents such as ondansetron, granisetron, and dolasetron
  • medications that block a protein in the body (CYP3A4) such as some macrolide antibiotics (clarithromycin, telithromycin), some HIV protease inhibitors (indinavir, nelfinavir, ritonavir, saquinavir), some HCV protease inhibitors (boceprevir, telaprevir), some azole antifungals (ketoconazole, itraconazole, posaconazole, voriconazole), delavirdine (Rescriptor), and nefazodone
  • medications that increase the activity of the enzyme CYP3A4 such as carbamazepine (Tegretol, Equetro, Carbatrol), phenobarbital, phenytoin (Dilantin), rifampin (Rifadin), and St John's wort

This is not a complete list of Cinvanti drug interactions. Ask your doctor or pharmacist for more information.

Cinvanti Precautions

Serious side effects have been reported with Cinvanti including the following:

  • serious allergic reactions. Allergic reactions can happen with aprepitant and may be serious. Stop taking aprepitant and call your doctor right away if you have any of these signs or symptoms of an allergic reaction:
    • hives
    • rash
    • itching
    • trouble breathing or swallowing.
  • reaction at the site of infusion. Tell your healthcare provider if you have any redness, warmth, or swelling at the infusion.

Do not take Cinvanti if you:

  • are allergic to Cinvanti or to any of its ingredients
  • are taking pimozide

Cinvanti Food Interactions

Medications can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of Cinvanti, there are no specific foods that you must exclude from your diet when receiving this medication.

Inform MD

Before taking Cinvanti, tell your doctor about all of your medical conditions. Especially tell your doctor if you:

  • are allergic to Cinvanti or to any of its ingredients
  • have liver problems
  • are pregnant or plan to become pregnant
  • are breastfeeding or plan to breastfeed

Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements.

Cinvanti and Pregnancy

Tell your doctor if you are pregnant or plan to become pregnant.

No well-controlled studies have been done in humans. However, Cinvanti should be avoided during pregnancy because of the alcohol content.

For women you use hormone-containing birth control (such as oral birth control, implants, and certain IUDs), it is recommended to use a back-up method of birth control that does not contain hormones (such as condoms) during treatment with Cinvanti and for 1 month after receiving the last dose of Cinvanti.

Cinvanti and Lactation

Tell your doctor if you are breastfeeding or plan to breastfeed.

It is not known if Cinvanti crosses into human milk. Because many medications can cross into human milk and because of the possibility for serious adverse reactions in nursing infants with use of this medication, a choice should be made whether to stop nursing or stop the use of this medication. Your doctor and you will decide if the benefits outweigh the risk of using Cinvanti.

Cinvanti Usage

Cinvanti is given on Day 1 of chemotherapy for the following regimens:

High emetogenic chemotherapy (Single Dose Regimen):

  • Cinvanti is administered on Day 1 only as an infusion over 30 minutes initiated approximately 30 minutes prior to chemotherapy. Cinvanti is part of a regimen to prevent nausea and vomiting induced by chemotherapy that includes a corticosteroid and a 5-HT3 antagonist. 

Moderate emetogenic chemotherapy (3-Day Dosing Regimen):

  • Cinvanti is administered on Day 1 as an infusion over 30 minutes initiated approximately 30 minutes prior to chemotherapy. Civanti e part of a regimen to prevent nausea and vomiting induced by chemotherapy that includes a corticosteroid, a 5-HT3 antagonist, and aprepitant.

Cinvanti Dosage

The Cinvanti dose you receive is based on the type of chemotherapy you are receiving. Your heatlhcare provider will decide which dose is right for you.

High emetogenic chemotherapy (Single Dose Regimen):

  • The recommended dose of Cinvanti for the prevention of nausea and vomiting for high emetogenic chemotherapy is 130 mg given to you by intravenous (IV) injection 30 minutes before you start your chemotherapy treatment.

Moderate emetogenic chemotherapy (3-Day Dosing Regimen):

  • The recommended dose of Cinvanti for the prevention of nausea and vomiting for moderate emetogenic chemotherapy is 100 mg given to you by intravenous (IV) injection 30 minutes before you start your chemotherapy treatment.

Cinvanti Overdose

If Cinvanti is administered by a healthcare provider in a medical setting, it is unlikely that an overdose will occur. However, if overdose is suspected, seek emergency medical attention.