Ultram

Ultram is used for moderate to moderately severe pain. It also has weak antidepressant effects. May not be suitable in people with a history of seizures.

Ultram Overview

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Ultram is a prescription medication used to relieve moderate to moderate severe pain. Ultram is in a class of medications called opiate (narcotic) pain relievers. It works by changing the way the brain and nervous system respond to pain.

This medication comes in a tablet and can be taken up to 6 times a day, with or without food.

Common side effects of Ultram include nausea, constipation, dry mouth, and fatigue. Ultram can also cause dizziness or drowsiness. Do not drive or operate heavy machinery until you know how Ultram affects you.

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Ultram Cautionary Labels

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Uses of Ultram

Ultram is a prescription medication used to treat moderate to moderately severe pain.

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

Manufacturer

Ultram Drug Class

Ultram is part of the drug class:

Side Effects of Ultram

Serious side effects have been reported with Ultram. See "Drug Precautions" section.

Common side effects of Ultram include:

  • dizziness
  • nausea
  • constipation
  • drowsiness
  • vomiting
  • itching skin
  • nervousness, agitation, or general change of mood
  • uncontrollable shaking of a part of the body
  • muscle tightness
  • heartburn or indigestion
  • dry mouth

This is not a complete list of Ultram side effects. Ask your doctor or pharmacist for more information.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Ultram Interactions

Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you take:

  • digoxin (Lanoxin)
  • warfarin (Coumadin, Jantoven)
  • central nervous system depressants such as alcohol, tranquilizers, or sedative hypnotics
  • other opioid medications such as hydrocodone (Vicodin) or oxycodone (Oxycontin)
  • medications that block the enzyme CYP3A4 such as some macrolide antibiotics (clarithromycin, telithromycin), some HIV protease inhibitors (indinavir, nelfinavir, ritonavir, saquinavir), some HCV protease inhibitors (boceprevir, telaprevir), some azole antifungals (ketoconazole, itraconazole, posaconazole, voriconazole), conivaptan (Vaprisol), delavirdine (Rescriptor), and nefazodone (Serzone)
  • medications that increase the activity of the enzyme CYP3A4 such as carbamazepine (Tegretol, Equetro, Carbatrol), phenobarbital, phenytoin (Dilantin), rifampin (Rifadin), St John's wort, and nimodipine (Nimotop)
  • medications that block the enzyme CYP2D6 such as quinidine (Qualaquin), fluoxetine (Prozac,Sarafem), amitriptyline (Elavil, Amitril, Amitid), and paroxetine (Paxil)
  • triptans such as sumatriptan (Imitrex, Treximet), eletriptan (Relpax), almotriptan (Axert), frovatriptan (Frova), naratriptan (Amerge), rizatriptan (Maxalt), and zolmitriptan (Zomig)
  • monoamine oxidase inhibitors such as tranylcypromine (Parnate), phenelzine (Nardil), selegiline (Eldepryl, Zelapar), isocarboxazid (Marplan), and rasagiline (Azilect)
  • selective serotonin reuptake inhibitors (SSRIs) such as escitalopram (Lexapro), sertraline (Zoloft), citalopram (Celexa), vilazodone (Viibryd), paroxetine (Paxil), fluoxetine (Prozac, Sarafem, Symbyax), and fluvoxamine (Luvox)
  • tricyclic antidepressants such as trimipramine (Surmontil), amitriptyline (Elavil), nortriptyline (Pamelor, Aventyl), protriptyline (Vivactil), and clomipramine (Anafranil)
  • other tricyclic compounds such as cyclobenzaprine (Flexeril) and promethazine (Phenergan)

This is not a complete list of Ultram drug interactions.  Ask your doctor or pharmacist for more information.

Ultram Precautions

Serious side effects have been reported with Ultram including the following:

  • seizures. Tell your healthcare provider right away if you have some or all of the following symptoms of seizures:
    • body convulsions (shaking and trembling)
    • temporary loss of consciousness
  • serotonin syndrome. Tell your healthcare provider right away if you have some or all of the following symptoms of serotonin syndrome:
    • hallucinations
    • fast heart rate
    • overactive reflexes
    • high blood pressure
    • restlessness or agitation
    • nausea or vomiting
    • decline in muscle coordination
    • rise in body temperature
  • discontinuation symptoms. Do not stop Ultram without first talking to your healthcare provider. Stopping Ultram suddenly may cause serious symptoms including the following:
    • anxiety
    • sweating
    • insomnia
    • shaking or shivering
    • pain
    • nausea
    • diarrhea
    • upper airway symptoms
    • goose bumps
    • rarely hallucinations

Ultram can cause dizziness or drowsiness. Do not drive or operate heavy machinery until you know how Ultram affects you.

Do not take Ultram if you:

  • are allergic to Ultram or any of its ingredients
  • have a history of respiratory depression in unmonitored settings or the absence of corrective measures
  • have a history of acute or chronic bronchial asthma or hypercapnia in unmonitored settings or the absence of corrective measures

Ultram Food Interactions

Medicines can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of Ultram, there are no specific foods that you must exclude from your diet when receiving Ultram.

Inform MD

Before taking Ultram, tell your doctor about all of your medical conditions. Especially tell your doctor if you:

  • are allergic to Ultram or to any of its ingredients
  • have respiratory problems
  • have a history of seizures or are at risk of seizures
  • have medical problems with your digestive tract
  • have or have had depression
  • have a history of substance or alcohol abuse
  • are consuming large amounts of alcohol
  • have liver problems
  • have kidney problems
  • are pregnant or breastfeeding

Tell your doctor about all the medicines you take including prescription and non-prescription medicines,

Ultram and Pregnancy

Tell your doctor if you are pregnant or plan to become pregnant.

The FDA categorizes medications based on safety for use during pregnancy. Five categories - A, B, C, D, and X, are used to classify the possible risks to an unborn baby when a medication is taken during pregnancy.

Ultram falls into category C. In animal studies, pregnant animals were given this medication and had some babies born with problems. No well-controlled studies have been done in humans. Therefore, this medication may be used if the potential benefits to the mother outweigh the potential risks to the unborn child.

Ultram and Lactation

Tell your doctor if you are breastfeeding or plan to breastfeed.

Ultram has been detected in human breast milk. Because of the possibility for adverse reactions in nursing infants from Ultram, a choice should be made whether to stop nursing or to stop use of this medication. The importance of the drug to the mother should be considered.

Ultram Usage

Take Ultram exactly as prescribed.

This medication comes in immediate release tablet and can be taken up to 6 times a day, with or without food.

If you miss a dose, take the missed dose as soon as you remember. If it is almost time for the next dose, skip the missed dose and take your next dose at the regular time. Do not take two doses of Ultram at the same time.

Ultram Dosage

Take Ultram exactly as prescribed by your doctor. Follow the directions on your prescription label carefully.

The Ultram dose your doctor recommends will be based on the following:

  • the severity of your pain
  • other medical conditions you have
  • other medications you are taking
  • how you respond to this medication
  • your age

The recommended dose range of Ultram is 50 to 100 mg every 4 to 6 hours as needed. Do not take more than 400 mg in a 24-hour period.

Ultram Overdose

If you take too much Ultram, call your healthcare provider or local Poison Control Center, or seek emergency medical attention right away.

If Ultram is administered by a healthcare provider in a medical setting, it is unlikely that an overdose will occur. However, if overdose is suspected, seek emergency medical attention.

Other Requirements

  • Store Ultram between 59°F to 86°F (15°C to 30°C).
  • Keep Ultram and all medicines out of the reach of children.