Hydrocodone

Hydrocodone relieves severe pain. Hydrocodone can cause nausea, vomiting, constipation, drowsiness, and rash.

Hydrocodone Overview

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Hydrocodone is a prescription medication used to relieve severe pain. Hydrocodone belongs to a group of drugs called narcotic analgesics. These work by changing the way that the brain and nervous system respond to pain.

This medication comes in an extended release capsule and tablet form and is taken up to two times a day, depending on which formulation you are taking.

Do not chew, divide, crush, dissolve, or break hydrocodone extended release capsules and tablets. Swallow the capsules and tablets whole.

This medication is also available in many combination products. This medication page refers to the single-ingredient preparation.

Common side effects of hydrocodone include nausea, vomiting, constipation, lightheadedness, anxiety, mood changes, rash, and itching.

Hydrocodone can also cause drowsiness and dizziness. Do not drive or operate heavy machinery until you know how hydrocodone affects you.

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Hydrocodone Cautionary Labels

precautionsprecautionsprecautionsprecautions

Uses of Hydrocodone

Hydrocodone is a prescription medication used to relieve severe pain in patients who require daily, around-the-clock, long-term treatment with opioid analgesics.

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

Hydrocodone Brand Names

Hydrocodone may be found in some form under the following brand names:

Hydrocodone Drug Class

Hydrocodone is part of the drug class:

Side Effects of Hydrocodone

Serious side effects have been reported with hydrocodone. See the Hydrocodone Precautions” section.

Common side effects of hydrocodone include the following:

  • Nausea
  • Vomiting
  • Constipation
  • Drowsiness
  • Dizziness
  • Lightheadedness
  • Headache
  • Fuzzy thinking
  • Anxiety
  • Abnormally happy or abnormally sad mood
  • Dry throat
  • Difficulty urinating
  • Rash
  • Itching
  • Narrowing of the pupils
  • Upper respiratory tract infection

This is not a complete list of hydrocodone side effects. Ask your doctor or pharmacist for more information.

Tell your doctor if you have any side effect that bothers you or that does not go away.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Hydrocodone Interactions

Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you take:

  • Antidepressants
  • Antihistamines
  • Antipsychotics (medications for mental illness)
  • Ipratropium (Atrovent)
  • Medications for irritable bowel disease, motion sickness, Parkinson's disease, seizures, ulcers, or urinary problems
  • Monoamine oxidase (MAO) inhibitors, including isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), and tranylcypromine (Parnate)
  • Sedatives
  • Sleeping pills
  • Tranquilizers

This is not a complete list of hydrocodone drug interactions. Ask your doctor or pharmacist for more information.

Hydrocodone Precautions

Serious side effects have been reported with hydrocodone including the following:

  • Life-threatening respiratory depression. Tell your healthcare provider right away if you have some or all of the following symptoms of respiratory depression:
    • Slowed or irregular breathing
    • Chest tightness

Hydrocodone can cause dizziness and drowsiness. Do not drive or operate heavy machinery until you know how hydrocodone affects you.

Do not take hydrocodone if you:

  • are allergic to hydrocodone or to any of its ingredients
  • are taking any other products containing hydrocodone or other narcotic medications, such as morphine or codeine

Hydrocodone Food Interactions

Medications can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of hydrocodone, there are no specific foods that you must exclude from your diet when receiving this medication.

Do not drink alcohol or take products containing alcohol while taking hydrocodone.

Inform MD

Before taking hydrocodone, tell your doctor about all of your medical conditions. Especially tell your doctor if you:

  • are allergic to hydrocodone or to any of its ingredients
  • have or have had lung disease
  • had recent surgery
  • have croup
  • have a head injury
  • have any conditions that increases pressure in your brain
  • have an enlarged prostate
  • have a narrowing of the urethra
  • have Addison’s disease
  • have glaucoma
  • have liver problems
  • have kidney problems
  • have thyroid disease
  • have intestinal disease
  • are pregnant or breastfeeding

Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements.

Hydrocodone and Pregnancy

Tell your doctor if you are pregnant or plan to become pregnant.

The FDA categorizes medications based on safety for use during pregnancy. Five categories - A, B, C, D, and X, are used to classify the possible risks to an unborn baby when a medication is taken during pregnancy.

Hydrocodone falls into category C. In animal studies, pregnant animals were given this medication and had some babies born with problems. No well-controlled studies have been done in humans. Therefore, this medication may be used if the potential benefits to the mother outweigh the potential risks to the unborn child.

 

 

Hydrocodone and Lactation

Tell your doctor if you are breastfeeding or plan to breastfeed.

Hydrocodone has been detected in human breast milk. Because of the possibility for adverse reactions in nursing infants from hydrocodone, a choice should be made whether to stop nursing or to stop use of this medication. The importance of the drug to the mother should be considered.

Hydrocodone Usage

Take hydrocodone exactly as prescribed.

Hydrocodone comes in extended release capsule form and is taken twice daily.

Hydrocodone also comes in a extended release tablet and is taken once a day. This formulation is difficult to crush, break or dissolve to reduce abuse.

Do not chew, divide, dissolve, or break extended release hydrocodone capsules and tablets. Swallow the capsules and tablets whole.

If you miss a dose, take your next dose at your usual time. Do not take two doses of hydrocodone at the same time.

Hydrocodone Dosage

Take this medication exactly as prescribed by your doctor. Follow the directions on your prescription label carefully.

The dose your doctor recommends may be based on the following:

  • other medical conditions you have
  • other medications you are taking
  • how you respond to this medication

The recommended dose range of hydrocodone capsules for the treatment of severe pain is 10 to 100 mg every 12 hours.

The recommended dose range of hydrocodone tablets for the treatment of severe pain is 20 to 120 mg once a day.

Hydrocodone Overdose

If you take too much hydrocodone, call your healthcare provider or local Poison Control Center, or seek emergency medical attention right away.

If hydrocodone is administered by a healthcare provider in a medical setting, it is unlikely that an overdose will occur. However, if overdose is suspected, seek emergency medical attention.

 

Other Requirements

  • Store hydrocodone at room temperature
  • Keep this and all medicines out of the reach of children.

Hydrocodone FDA Warning

WARNING: ADDICTION, ABUSE, AND MISUSE; LIFE-THREATENING RESPIRATORY DEPRESSION; ACCIDENTAL INGESTION; NEONATAL OPIOID WITHDRAWAL SYNDROME; INTERACTION WITH ALCOHOL; and CYTOCHROME P450 3A4 INTERACTION

Addiction, Abuse, and Misuse
Hydrocodone exposes patients and other users to the risks of opioid addiction, abuse, and misuse, which can lead to overdose and death. Assess each patient’s risk prior to prescribing hydrocodone and monitor all patients regularly for the development of these behaviors or conditions.

Life-threatening Respiratory Depression
Serious, life-threatening, or fatal respiratory depression may occur with use of ZOHYDRO ER. Monitor for respiratory depression, especially during initiation of hydrocodone or following a dose increase. Instruct patients to swallow ZOHYDRO ER capsules whole; crushing, chewing, or dissolving hydrocodone capsules can cause rapid release and absorption of a potentially fatal dose of hydrocodone.

Accidental Ingestion
Accidental ingestion of even one dose of hydrocodone, especially by children, can result in a fatal overdose of hydrocodone.

Neonatal Opioid Withdrawal Syndrome
Prolonged use of hydrocodone during pregnancy can result in neonatal opioid withdrawal syndrome, which may be life-threatening if not recognized and treated, and requires management according to protocols developed by neonatology experts. If opioid use is required for a prolonged period in a pregnant woman, advise the patient of the risk of neonatal opioid withdrawal syndrome and ensure that appropriate treatment will be available.

Interaction with Alcohol
Instruct patients not to consume alcoholic beverages or use prescription or non-prescription products that contain alcohol while taking hydrocodone. The co-ingestion of alcohol with hydrocodone may result in increased plasma levels and a potentially fatal overdose of hydrocodone.


The concomitant use of hydrocodone with all cytochrome P450 3A4 inhibitors may result in an increase in hydrocodone plasma concentrations, which could increase or prolong adverse drug effects and may cause potentially fatal respiratory depression. In addition, discontinuation of a concomitantly used cytochrome P450 3A4 inducer may result in an increase in hydrocodone plasma concentration. Monitor patients receiving hdrocodone and any CYP3A4 inhibitor or inducer.