Treximet (generic: sumatriptan/naproxen) is a prescription medication used to treat migraines in adults. Treximet comes as a tablet containing two prescription drugs. Sumatriptan belongs to a group of drugs called selective serotonin receptor agonists or "triptans", which narrow blood vessels in the head and prevent pain signals in the brain. Naproxen belongs to a group of drugs called non-steroidal anti-inflammatory drugs (NSAID), which prevent pain and inflammation.
This medication comes in tablet form and is one tablet is taken at the first sign of a migraine headache, with or without food. A second tablet may be taken after 2 hours if needed.
Common side effects of Treximet include drowsiness, diarrhea, and pain in the chest, neck, throat, or stomach.
Treximet is a prescription medicine used to treat adults with migraine attacks, once they have started.
This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.
Serious side effects include:
- heart attack
- heartbeat problems
- high blood pressure
- heart failure from body swelling (fluid retention)
- kidney problems including kidney failure
- bleeding and ulcers in the stomach and intestine
- low red blood cells (anemia)
- life-threatening skin reactions
- life-threatening allergic reactions
- liver problems including liver failure
- asthma attacks in people who have asthma
- loss of blood circulation to areas of your body
- serotonin syndrome
Other side effects include:
- pain, tightness, or pressure in the chest, neck, and throat
- stomach pain
- tingling and numbness
- unusual body sensations
- redness of face (flushed)
Get emergency help right away if you have any of the following symptoms:
- shortness of breath or trouble breathing
- chest pain
- swelling of the face or throat
- weakness in one part or on one side of your body
- slurred speech.
Stop Treximet and call your healthcare provider right away if you have any of the following symptoms:
- nausea that seems out of proportion to your migraine
- stomach pain
- sudden/severe pain in your belly
- vomit blood
- blood in your bowel movement or it is black and sticky like tar
- skin rash or blisters with fever
- yellow skin or eyes
- swelling of the arms and legs, hands, feet, face, lips, or tongue
- unusual weight gain
- more tired or weaker than usual
- flu-like symptoms
- serotonin syndrome. See "Drug Precautions".
Tell your healthcare provider if you have any side effects that bother you or do not go away. These are not all of the side effects of Treximet. For more information ask your healthcare provider.
Tell your healthcare provider about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements. Especially tell your healthcare provider if you take medicines for migraines, depression, or other health problems such as MAO inhibitors, SSRIs, or SNRIs. Examples include:
- isocarboxazid (Marplan)
- phenelzine (Nardil)
- selegiline (Emsam, Eldepryl)
- tranylcypromine (Parnate)
- dihydroergotamine (D.H.E. 45, Migranal)
- methysergide (Sansert)
- almotriptan (Axert)
- eletriptan (Relpax)
- frovatriptan (Frova)
- naratriptan (Amerge)
- rizatriptan (Maxalt, Maxalt-MLT)
- zolmitriptan (Zomig)
- citalopram (Celexa)
- escitalopram (Lexapro)
- fluoxetine (Prozac, Sarafem, in Symbyax)
- fluvoxamine (Luvox)
- paroxetine (Paxil)
- sertraline (Zoloft)
- duloxetine (Cymbalta)
- sibutramine (Meridia)
- venlafaxine (Effexor)
This is not a complete list of Treximet drug interactions. Ask your doctor or pharmacist for more information.
1. Treximet may increase your chance of a heart attack or stroke that can lead to death. Treximet contains 2 medicines: sumatriptan and naproxen sodium (a nonsteroidal anti-inflammatory drug [NSAID]).
Your chance of a heart attack or stroke increases:
- with longer use of NSAID medicines
- if you have heart disease.
2. Treximet should never be used right before or after a heart surgery called a coronary artery bypass graft (CABG).
3. Treximet can cause ulcers and bleeding in the stomach and intestines at any time during your treatment.
Ulcers and bleeding:
- can happen without warning symptoms
- may cause death.
Your chance of getting an ulcer or bleeding increases with:
- the use of medicines called steroid hormones (corticosteroids) and blood thinners (anticoagulants)
- longer use
- more frequent use
- drinking alcohol
- older age
- having poor health.
4. Treximet is not recommended for people with risk factors for heart disease unless a heart exam is done and shows no problems.
Risk factors for heart disease include:
- high blood pressure
- high cholesterol levels
- family history of heart disease
- female who has gone through menopause
- male over age 40.
5. “Serotonin syndrome” is a serious and life-threatening problem that may occur with Treximet, especially if used with antidepressant medicines called selective serotonin reuptake inhibitors (SSRIs) or selective norepinephrine reuptake inhibitors (SNRIs).
Commonly used SSRIs are:
- Celexa (citalopram HBr)
- Lexapro (escitalopram oxalate)
- Paxil (paroxetine)
- Prozac/Sarafem (fluoxetine)
- Symbyax (olanzapine/fluoxetine)
- Zoloft (sertraline)
- Luvox (fluvoxamine).
Commonly used SNRIs are:
- Cymbalta (duloxetine)
- Effexor (venlafaxine).
Call your healthcare provider if you have symptoms of serotonin syndrome, which include:
- mental changes (hallucinations, agitation, coma)
- fast heartbeat
- changes in blood pressure
- high body temperature or sweating
- tight muscles
- trouble walking
- nausea, vomiting, diarrhea.
6. Treximet should only be used:
- exactly as prescribed
- at the lowest dose possible for your treatment
- for the shortest time needed.
7. Treximet already contains an NSAID (naproxen). Do not use Treximet with other medicines to lessen pain or fever without talking to your healthcare provider first, because they may contain an NSAID also.
Do not take Treximet right before or after heart bypass surgery. Do not take Treximet if you have or have had:
- uncontrolled high blood pressure
- hemiplegic or basilar migraine. (Ask your doctor if you are not sure what type of migraine you have.)
- liver problems
- an asthma attack, hives, or other allergic reaction with aspirin or any other NSAID medicine
- a heart attack or a history or symptoms of heart disease (such as chest pain or angina)
- a stroke, mini-stroke (transient ischemic attack or TIA), or other stroke-like syndrome
- problems with blood circulation to parts of your body, such as less blood flow to your intestines (ischemic bowel disease)
- allergic reactions to sumatriptan, naproxen, or other ingredients in Treximet.
Do not take Treximet if you take or have taken an antidepressant medicine called a monoamine oxidase (MAO) inhibitor within the last 2 weeks. Common MAO inhibitors are isocarboxazid (Marplan), phenelzine (Nardil), tranylcypromine (Parnate), and selegiline (Eldepryl, Emsam). Ask your healthcare provider if you are not sure if your medicine is an MAO inhibitor.
Do not take Treximet if you have taken other migraine medicines in the last 24 hours such as:
- ergotamine-containing medicine or
- another triptan medicine.
Medicines can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of Treximet there are no specific foods that you must exclude from your diet when receiving Treximet.
Before starting Treximet, tell your healthcare provider about:
- all of your medical conditions including kidney or liver problems;
- all allergies to any medicines;
- chest pain, shortness of breath, irregular heartbeats;
- medicines you may take for migraines, depression, or other health problems such as MAO inhibitors, SSRIs, or SNRIs;
- all the prescription and non-prescription medicines you take, including vitamins and herbal supplements. Some medicines can interact with Treximet and cause serious side effects.
Keep a list of your medicines to show to your healthcare provider. Before starting Treximet, tell your healthcare provider if you:
- are pregnant, think you might be pregnant, or are trying to become pregnant. Treximet should not be used by pregnant women late in their pregnancy.
- are breastfeeding;
- have a headache that is different from your usual migraine;
- have or have had epilepsy or seizures.
Tell your healtcare provider if you are pregnant, think you might be pregnant, or are trying to become pregnant. Treximet should not be used by pregnant women late in their pregnancy.
Tell your doctor if you are breastfeeding or plan to breastfeed. Both active ingredients in Treximet, sumatriptan and naproxen sodium, may be excreted in human breast milk.
- Take 1 Treximet tablet to treat your migraine headache. Do not take more than 2 Treximet tablets in 24 hours. Doses should be separated by at least 2 hours.
- Treximet can be taken with or without food.
- Do not split, crush, or chew Treximet tablets.
Take Treximet exactly as prescribed. Follow the directions on your prescription label carefully.
The recommended dose is one tablet. Do not take more than 2 Treximet tablets in 24 hours.
If you take too much Treximet, call your local Poison Control Center or seek emergency medical attention right away.
Active ingredients: sumatriptan succinate and naproxen sodium
Inactive ingredients: croscarmellose sodium, dextrose monohydrate, dibasic calcium phosphate, FD&C Blue No. 2, lecithin, magnesium stearate, maltodextrin, microcrystalline cellulose, povidone, sodium bicarbonate, sodium carboxymethylcellulose, talc, and titanium dioxide.
- Store Treximet at room temperature, 59° to 86°F (15° to 30°C).
- Keep Treximet and all medicines out of the reach of children.
Cardiovascular Risk: Treximet may cause an increased risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke, which can be fatal. This risk may increase with duration of use. Patients with cardiovascular disease or risk factors for cardiovascular disease may be at greater risk (see WARNINGS: Cardiovascular Effects).
Gastrointestinal Risk: Treximet contains a nonsteroidal anti-inflammatory drug (NSAID). NSAID-containing products cause an increased risk of serious gastrointestinal adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. These events can occur at any time during use and without warning symptoms. Elderly patients are at greater risk for serious gastrointestinal events (see WARNINGS: Risk of Gastrointestinal Ulceration, Bleeding, and Perforation With Nonsteroidal Anti-inflammatory Drug Therapy).