Quinapril

Quinapril treats high blood pressure. This medication should not be used during pregnancy. Avoid salt substitutes containing potassium.

Quinapril Overview

Reviewed: July 1, 2013
Updated: 

Quinapril is a prescription medication used to treat high blood pressure and congestive heart failure. Quinapril belongs to a group of drugs called angiotensin converting enzyme (ACE) inhibitors, which relax blood vessels to lower blood pressure and make the heart more efficient.

This medication comes in tablet form and is taken once or twice daily. It should be taken on an empty stomach - one hour before, or two hours after a meal.

Common side effects of quinapril include headache, fatigue, and cough. Quinapril may cause dizziness. Do not drive or operate heavy machinery until you know how this medication affects you.

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  • Diabetic Nephropathies
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Quinapril Cautionary Labels

precautionsprecautionsprecautionsprecautionsprecautions

Uses of Quinapril

Quinapril is a prescription medication used to treat high blood pressure and congestive heart failure in adults.

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

Quinapril Brand Names

Quinapril may be found in some form under the following brand names:

Quinapril Drug Class

Quinapril is part of the drug class:

Side Effects of Quinapril

Serious side effects have been reported with quinapril. See “Drug Precautions” section.

Common side effects include:

  • headache
  • fatigue
  • dizziness
  • cough
  • extremely low blood pressure
  • nausea
  • vomiting
  • stomach pain

This is not a complete list of quinapril side effects. Ask your doctor or pharmacist for more information.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Quinapril Interactions

Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you take:

  • potassium-sparing diuretics such as:
  • other diuretics such as:
    • furosemide (Lasix)
    • hydrochlorothiazide
    • torsemide (Demadex)
  • aliskiren (Tekturna)
  • angiotensin receptor blockers such as candesartan (Atacand), losartan (Cozaar), and telmisartan (Micardis, Twynsta)
  • aspirin and other NSAIDs (non-steroidal anti-inflammatory drugs) such as:
    • celecoxib (Celebrex)
    • diclofenac (Cambia, Cataflam, Flector, Voltaren, Zipsor and others)
    • etodolac (Lodine)
    • ibuprofen (Advil, Motrin, Nuprin)
    • indomethacin (Indocin, Indocin SR)
    • ketoprofen (Orudis, Actron, Oruvail)
    • ketorolac (Toradol)
    • meloxicam (Mobic)
    • nabumetone (Relafen)
    • naproxen (Naprosyn)
    • naproxen sodium (Aleve, Anaprox, Naprelan)
    • oxaprozin (Daypro)
    • piroxicam (Feldene)
  • lithium (Eskalith, Lithobid)
  • potassium supplements
  • injectable gold (sodium aurothiomalate)

This is not a complete list of quinapril drug interactions. Ask your doctor or pharmacist for more information.

Quinapril Precautions

Serious side effects have been reported with quinapril including:

  • Hypotension: excessive perspiration and dehydration may lead to an excessive fall in blood pressure (hypotension). Vomiting or diarrhea may also lead to a fall in blood pressure.
  • Decline in kidney function: Your doctor may need to perform tests to determine the stability of the function of your kidneys, especially in patients who already have kidney dysfunction.
  • Hyperkalemia: Quinapril may lead to increased levels of potassium, which could lead to side effects such as heart arrhythmias (irregular heartbeat) and nausea.
  • Cough: Persistent dry cough has been reported with all ACE inhibitors, and will resolve after discontinuation of therapy.
  • Valvular Stenosis: Those with aortic stenosis (stiffening of the main artery that carries blood away from the heart) might be at risk of decreased blood flow to the rest of the body.
  • Angioedema: Tell your healthcare profession right away if you have signs or symptoms of angioedema, which include:
    • swelling of face, eyes, lips, tongue, larynx and extremities
    • difficulty in swallowing or breathing
    • hoarseness (having difficulty making sounds when trying to speak)
  • Neutropenia: report any sign of infection such as sore throat or fever, which may be a sign of neutropenia (a decreased amount of white blood cells).
  • Edema: report any sign of edema (increase in swelling of the arms or legs), which may be a sign of declining kidney function.
  • Heart failure patients: caution is advised against rapid increases in exercise or physical activity for those who are being treated for heart failure.
  • Intestinal Angioedema: Intestinal angioedema (swelling within the gut) has been reported in patients treated with ACE inhibitors. Report signs and symptoms of intestinal angioedema, including abdominal (stomach-area) pain, with or without nausea or vomiting.
  • Liver failure: This is a rare occurrence. Nevertheless, report any signs or symptoms of hepatic failure, including:
    • yellowing of the skin or eyes
    • nausea
    • vomiting
    • fatigue
    • itching

Quinapril can cause dizziness. Do not drive or operate heavy machinery until you know how quinapril affects you.

Do not take quinapril if you are hypersensitive to this product. Signs of a hypersensitivity reaction include:

  • chest pain
  • swelling of the face, eyes, lips, tongue, arms, or legs
  • difficulty breathing or swallowing
  • fainting
  • rash

Quinapril Food Interactions

Medications can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of quinapril, salt substitutes containing potassium should be avoided.

 

Inform MD

Before taking quinapril, tell your doctor about all of your medical conditions. Especially tell your doctor if you:

  • have a history of angioedema (swelling under the skin)
  • have diabetes (high blood sugar) and you are taking aliskiren (Tekturna; also in Amturnide, Tekamlo, Tekturna HCT). Your doctor will probably tell you not to take quinapril if you have diabetes and you are also taking aliskiren.
  • have or have ever had heart or kidney disease or diabetes
  • have liver disease
  • are having surgery, including dental surgery. Inform the doctor or dentist that you are taking quinapril.
  • are using salt substitutes containing potassium. If your doctor prescribes a low-salt or low-sodium diet, follow these instructions carefully.
  • pregnant or breastfeeding

Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements.

Quinapril and Pregnancy

Tell your doctor if you are pregnant or plan to become pregnant. Quinapril is usually not recommended for use during pregnancy. See "FDA Warning" section.

The FDA categorizes medications based on safety for use during pregnancy. Five categories - A, B, C, D, and X, are used to classify the possible risks to an unborn baby when a medication is taken during pregnancy.

Quinapril falls into category D. It has been shown that use of quinapril in pregnant women caused some babies to be born with problems. More specifically, it has been shown that use of drugs like quinapril during the second and third trimesters of pregnancy harms the unborn baby’s kidneys and even increases the risk of death to the unborn baby. A more recent study showed that there may, in fact, also be an increased risk to the fetus if it is exposed to quinapril during the first trimester.

However, in some situations the benefit of using this medication may be greater than the risk of harm to the baby.

Quinapril and Lactation

Tell your doctor if you are breastfeeding or plan to breastfeed.

Quinapril has been detected in human breast milk. Because of the possibility for adverse reactions in nursing infants from quinapril, a choice should be made whether to stop nursing or to stop use of this medication. Determining the importance of the drug to the mother should be considered.

Quinapril Usage

  • Take quinapril exactly as prescribed.
  • Quinapril comes in tablet form and is taken once or twice daily.
  • Take quinapril on an empty stomach - one hour before, or two hours after a meal.
  • If you miss a dose, take the missed dose as soon as you remember. If it is almost time for the next dose, skip the missed dose and take your next dose at the regular time. Do not take two doses of quinapril at the same time.

Quinapril Dosage

Take quinapril exactly as prescribed by your doctor. Follow the directions on your prescription label carefully.

High Blood Pressure: The recommended starting dose of quinapril for the treatment of high blood pressure is 10 mg or 20 mg once daily or divided into two smaller doses.

Congestive Heart Failure: The recommended starting dose of quinapril for the treatment of congestive heart failure is 5 mg twice a day.

Based on how your body responds to the medication and side effects you experience your healthcare provider may decide to increase or decrease your dose. The dose you receive is also based on the following factors:

  • your age
  • the medical condition you are being treated for
  • other medical conditions you may have 
  • other medications you are taking including diuretics

Quinapril Overdose

If you take too much quinapril call your healthcare provider or poison control center, or seek emergency medical attention right away.

Other Requirements

Store at controlled room temperature between 15º–30ºC (59º–86ºF).

Keep this and all medications out of the reach of children.

Quinapril FDA Warning

WARNING: FETAL TOXICITY

  • When pregnancy is detected, discontinue quinapril as soon as possible.
  • Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus.