Amturnide

Amturnide treats high blood pressure. This medication has three components, aliskiren, amlodipine, and hydrochlorothiazide. Do not take Amturnide during pregnancy.

Amturnide Overview

Reviewed: August 31, 2012
Updated: 

Amturnide is a prescription medication used to treat high blood pressure. It is a single product containing 3 medications: aliskiren, amlodipine, and hydrochlorothiazide. Aliskiren belongs to a group of drugs called renin inhibitors, which work by reducing renin production in the body to reduce blood pressure. Amlodipine belongs to a group of drugs called calcium channel blockers, which help relax blood vessels. This makes it easier for the heart to pump blood. Hydrochlorothiazide belongs to a group of drugs called thiazide diuretics, which work by stopping reabsorption of salt into your body. This prevents fluid from building up in the body.

This medication comes in tablet form and is typically given once daily with or without food. Make sure to take it the same way every time. For example, always take it with food or always take it without food. 

Common side effects of Amturnide include retaining fluid (edema), headache, and infection of the nose and throat (nasopharyngitis).

Amturnide can also cause tiredness and dizziness. Do not drive or operate heavy machinery until you know how Amturnide affects you. 

This brand is no longer available. 

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Amturnide Cautionary Labels

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Uses of Amturnide

Amturnide is a prescription medication used to treat high blood pressure.

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information. 

Manufacturer

Amturnide Drug Class

Amturnide is part of the drug class:

Side Effects of Amturnide

Serious side effects have been reported with Amturnide. See the "Amturnide Precautions" section. 

Common side effects of Amturnide include the following:

  • retaining fluid (edema) that causes swelling of your ankles, feet, and hands
  • dizziness
  • headache
  • infection of the nose and throat (nasopharyngitis)
  • cough
  • tiredness
  • high levels of potassium in the blood (hyperkalemia)

This is not a complete list of Amturnide side effects. Ask your doctor or pharmacist for more information. 

Tell your doctor if you have any side effect that bothers you or that does not go away.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Amturnide Interactions

No drug interactions have been evaluated by the manufacturer for Amturnide. However, you should tell your doctor about all the medicines you take including prescription and nonprescription medicines, vitamins and herbal supplements. Not all drug interactions are known or reported and new drug interactions are continually being reported. Medicines that may cause interactions due to the medicines in Amturnide include the following:

  • a kind of medicine to control blood pressure called an angiotensin receptor blocker (ARB) or angiotensin-converting enzyme inhibitor (ACEI)
  • medicines used to lower blood pressure, water pills (also called “diuretics”),especially potassium sparing diuretics
  • medicines for treating fungus or fungal infections (like itraconazole or ketoconazole)
  • cyclosporine (Gengraf , Neoral, Sandimmune), a medicine used to suppress the immune system
  • potassium-containing medicines, potassium supplements, or salt substitutes containing potassium
  • cholesterol lowering medicines such as simvastatin (Zocor ) or atorvastatin (Lipitor ), cholestyramine (Questran, Questran Light, Cholestyramine Light, Locholest Light, Locholest, Prevalite), and colestipol (Colestipol hydrochloride, Colestid, Flavored Colestid)
  • medicines used to treat diabetes, including insulin
  • lithium, a medicine used to treat some types of depression
  • nonsteroidal anti-inflammatory drugs (NSAIDs) (like ibuprofen or naproxen), including selective Cyclooxygenase-2 inhibitors (COX-2 inhibitors)
  • medicines used to treat AIDS or HIV infections (such as ritonavir, indinavir).

Do not drink alcohol while taking this medication.

Ask your doctor or pharmacist for more information. 

Amturnide Precautions

Serious side effects have been reported with Amturnide or its ingredients including the following:

  • Allergic reactions. Tell your healthcare provider right away if you have some or all of the following symptoms:
    • swelling of the face, limbs, lips, tongue, throat
    • difficulty breathing
    • stomach (abdominal) pain (intestinal angioedema) with or without nausea or vomiting
  • Harm to an unborn baby (fetal toxicity). Do not take Amturnide if you are pregnant or will become pregnant.
  • Low blood pressure (hypotension). Your blood pressure may get too low if you also take water pills, are on a low-salt diet, get dialysis treatments, have heart problems, or get sick with vomiting or diarrhea. Drinking alcohol and taking certain medicines (barbiturates or narcotics) can cause low blood pressure to get worse. Lie down if you feel faint or dizzy, and call your doctor right away.
  • Worsening chest pain or heart attack. When you first start taking Amturnide or increase your dose, you may have a heart attack or your angina may get worse. If that happens, call your doctor right away or go directly to the nearest hospital emergency room.
  • Eye problems. One of the medicines in Amturnide can cause eye problems that may lead to vision loss. Symptoms of eye problems can happen within hours to weeks of starting Amturnide. Tell your doctor right away if you have:
    • decrease in vision
    • eye pain
  • Kidney impairment or failure. Aliskiren, one of the medicines in Amturnide, may cause kidney disorder with symptoms such as severely decreased urine output or decreased urine output.
  • Imbalances in the levels of salts and fluids in your body (electrolyte and fluid imbalance). Tell your healthcare provider right away if you have some or all of the following symptoms:
    • dry mouth
    • thirst
    • weakness
    • drowsiness
    • restlessness
    • muscle pains or cramps
    • low blood pressure
    • low output of urine
    • fast heart rate
    • nausea
    • vomiting

Amturnide can cause tiredness and dizziness. Do not drive or operate heavy machinery until you know how Amturnide affects you.

Do not take Amturnide if you:

  • are allergic to aliskiren, hydrochlorothiazide, amlodipine, other medicines that contain sulfonamide, or any other ingredients in Amturnide
  • have diabetes and are taking a kind of medicine called an angiotensin receptor blocker (ARB) or angiotensin-converting enzyme inhibitor (ACEI)
  • your kidneys do not produce urine (anuria)

Amturnide Food Interactions

Medications can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of Amturnide, salt substitutes containing potassium should be avoided. 

Inform MD

Before taking Amturnide, tell your doctor about all of your medical conditions. Especially tell your doctor if you:

  • are allergic to aliskiren, hydrochlorothiazide, amlodipine, other medicines that contain sulfonamide, or any other ingredients in Amturnide
  • have diabetes and are taking a kind of medicine called an angiotensin receptor blocker (ARB) or angiotensin-converting enzyme inhibitor (ACEI)
  • your kidneys do not produce urine (anuria)
  • have a kidney or liver problem
  • have signs of systemic lupus erythematosus (SLE)
  • have ever had an allergic reaction to another blood pressure medicine. Symptoms may include: swelling of the face, lips, tongue, throat, arms and legs, and trouble breathing (angioedema)
  • suffer from heart disorders or if you experienced a heart attack
  • are pregnant or planning to become pregnant
  • are breastfeeding or plan to breastfeed

Tell you doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements. 

 

Amturnide and Pregnancy

Tell your doctor if you are pregnant or plan to become pregnant.

The FDA categorizes medications based on safety for use during pregnancy. Five categories - A, B, C, D, and X, are used to classify the possible risks to an unborn baby when a medication is taken during pregnancy.

Amturnide falls into category D. When pregnancy is detected, discontinue Amturnide as soon as possible. Drugs that act directly on the renin-angiotensin system can cause injury and death to the unborn baby.

Amturnide and Lactation

Tell your doctor is you are breastfeeding or plan to breastfeed. 

It is not known whether aliskiren or amlodipine, two components of Amturnide, are excreted in human milk. Hydrochlorothiazide, the other component of Amturnide, has been detected in human breast milk. Because of the possibility for adverse reactions in nursing infants from Amturnide, a choice should be made whether to stop nursing or to stop taking this medication. The importance of the drug to the mother should be considered. 

Amturnide Usage

  • Take Amturnide exactly as prescribed by your doctor.
  • It is important to take Amturnide every day to control your blood pressure.
  • Take Amturnide 1 time a day, at about the same time each day.
  • Take Amturnide the same way every day, either with or without a meal.
  • Your doctor may change your dose of Amturnide if needed. Do not change the amount of Amturnide you take without talking to your doctor first.
  • If you miss a dose of Amturnide, take it as soon as you remember. If it is close to your next dose, do not take the missed dose. Just take the next dose at your regular time

Amturnide Dosage

Take this medication exactly as prescribed by your doctor. Follow the directions on your prescription label carefully.

The dose your doctor recommends may be based on the following:

  • your blood pressure
  • previous medications used and the doses tried
  • how you respond to this medication

The maximum recommended daily dose of Amturnide is aliskiren 300 mg, amlodipine 10 mg, and  hydrochlorothiazide 25 mg.

Amturnide Overdose

If you take too much Amturnide, call your healthcare provider or local Poison Control Center, or seek emergency medical attention right away. 

Other Requirements

  • Store Amturnide tablets at room temperature between 59°F to 86°F (15°C to 30°C).
  • Keep Amturnide in the original container.
  • Protect Amturnide from heat and moisture.
  • Keep this and all medications out of the reach of children. 

Amturnide FDA Warning

WARNING: FETAL TOXICITY

  • When pregnancy is detected, discontinue Amturnide as soon as possible. 
  • Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus.