Accupril treats high blood pressure. This medication should not be used during pregnancy. Avoid salt substitutes containing potassium.

Accupril Overview


Accupril is a prescription medication used to treat high blood pressure and congestive heart failure. Accupril belongs to a group of drugs called angiotensin converting enzyme (ACE) inhibitors, which relax blood vessels to lower blood pressure and make the heart more efficient.

This medication comes in tablet form and is taken once or twice daily. It should be taken on an empty stomach - one hour before, or two hours after a meal.

Common side effects of Accupril include headache, fatigue, and cough. Accupril may cause dizziness. Do not drive or operate heavy machinery until you know how this medication affects you.

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  • Other
  • Diabetic Nephropathies
  • Heart Failure
  • Hypertension
  • Hypertrophy, Left Ventricular
  • Ventricular Dysfunction, Left

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Accupril Cautionary Labels


Uses of Accupril

Accupril is a prescription medication used to treat high blood pressure and congestive heart failure in adults.

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.


Accupril Drug Class

Accupril is part of the drug class:

Side Effects of Accupril

Serious side effects have been reported with Accupril. See “Drug Precautions” section.

Common side effects include:

  • headache
  • fatigue
  • dizziness
  • cough
  • extremely low blood pressure
  • nausea
  • vomiting
  • stomach pain

This is not a complete list of Accupril side effects. Ask your doctor or pharmacist for more information.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Accupril Interactions

Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you take:

  • potassium-sparing diuretics such as:
  • other diuretics such as:
  • aliskiren (Tekturna)
  • angiotensin receptor blockers such as candesartan (Atacand), losartan (Cozaar), and telmisartan (Micardis, Twynsta)
  • aspirin and other NSAIDs (non-steroidal anti-inflammatory drugs) such as:
    • celecoxib (Celebrex)
    • diclofenac (Cambia, Cataflam, Flector, Voltaren, Zipsor and others)
    • etodolac (Lodine)
    • ibuprofen (Advil, Motrin, Nuprin)
    • indomethacin (Indocin, Indocin SR)
    • ketoprofen (Orudis, Actron, Oruvail)
    • ketorolac (Toradol)
    • meloxicam (Mobic)
    • nabumetone (Relafen)
    • naproxen (Naprosyn)
    • naproxen sodium (Aleve, Anaprox, Naprelan)
    • oxaprozin (Daypro)
    • piroxicam (Feldene)
  • lithium (Eskalith, Lithobid)
  • potassium supplements
  • injectable gold (sodium aurothiomalate)

This is not a complete list of Accupril drug interactions. Ask your doctor or pharmacist for more information.

Accupril Precautions

Serious side effects have been reported with Accupril including:

  • Hypotension: excessive perspiration and dehydration may lead to an excessive fall in blood pressure (hypotension). Vomiting or diarrhea may also lead to a fall in blood pressure.
  • Decline in kidney function: Your doctor may need to perform tests to determine the stability of the function of your kidneys, especially in patients who already have kidney dysfunction.
  • Hyperkalemia: Accupril may lead to increased levels of potassium, which could lead to side effects such as heart arrhythmias (irregular heartbeat) and nausea.
  • Cough: Persistent dry cough has been reported with all ACE inhibitors, and will resolve after discontinuation of therapy.
  • Valvular Stenosis: Those with aortic stenosis (stiffening of the main artery that carries blood away from the heart) might be at risk of decreased blood flow to the rest of the body.
  • Angioedema: Tell your healthcare profession right away if you have signs or symptoms of angioedema, which include:
    • swelling of face, eyes, lips, tongue, larynx and extremities
    • difficulty in swallowing or breathing
    • hoarseness (having difficulty making sounds when trying to speak)
  • Neutropenia: report any sign of infection such as sore throat or fever, which may be a sign of neutropenia (a decreased amount of white blood cells).
  • Edema: report any sign of edema (increase in swelling of the arms or legs), which may be a sign of declining kidney function.
  • Heart failure patients: caution is advised against rapid increases in exercise or physical activity for those who are being treated for heart failure.
  • Intestinal Angioedema: Intestinal angioedema (swelling within the gut) has been reported in patients treated with ACE inhibitors. Report signs and symptoms of intestinal angioedema, including abdominal (stomach-area) pain, with or without nausea or vomiting.
  • Liver failure: This is a rare occurrence. Nevertheless, report any signs or symptoms of hepatic failure, including:
    • yellowing of the skin or eyes
    • nausea
    • vomiting
    • fatigue
    • itching

Accupril can cause dizziness. Do not drive or operate heavy machinery until you know how Accupril affects you.

Do not take Accupril if you are hypersensitive to this product. Signs of a hypersensitivity reaction include:

  • chest pain
  • swelling of the face, eyes, lips, tongue, arms, or legs
  • difficulty breathing or swallowing
  • fainting
  • rash

Accupril Food Interactions

Medications can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of Accupril, salt substitutes containing potassium should be avoided.


Inform MD

Before taking Accupril, tell your doctor about all of your medical conditions. Especially tell your doctor if you:

  • have a history of angioedema (swelling under the skin)
  • have diabetes (high blood sugar) and you are taking aliskiren (Tekturna; also in Amturnide, Tekamlo, Tekturna HCT). Your doctor will probably tell you not to take Accupril if you have diabetes and you are also taking aliskiren.
  • have or have ever had heart or kidney disease or diabetes
  • have liver disease
  • are having surgery, including dental surgery. Inform the doctor or dentist that you are taking Accupril.
  • are using salt substitutes containing potassium. If your doctor prescribes a low-salt or low-sodium diet, follow these instructions carefully.
  • pregnant or breastfeeding

Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements.

Accupril and Pregnancy

Tell your doctor if you are pregnant or plan to become pregnant. Accupril is usually not recommended for use during pregnancy. See "FDA Warning" section.

The FDA categorizes medications based on safety for use during pregnancy. Five categories - A, B, C, D, and X, are used to classify the possible risks to an unborn baby when a medication is taken during pregnancy.

Accupril falls into category D. It has been shown that use of Accupril in pregnant women caused some babies to be born with problems. More specifically, it has been shown that use of drugs like Accupril during the second and third trimesters of pregnancy harms the unborn baby’s kidneys and even increases the risk of death to the unborn baby. A more recent study showed that there may, in fact, also be an increased risk to the fetus if it is exposed to Accupril during the first trimester.

However, in some situations the benefit of using this medication may be greater than the risk of harm to the baby.

Accupril and Lactation

Tell your doctor if you are breastfeeding or plan to breastfeed.

Accupril has been detected in human breast milk. Because of the possibility for adverse reactions in nursing infants from Accupril , a choice should be made whether to stop nursing or to stop use of this medication. Determining the importance of the drug to the mother should be considered.

Accupril Usage

  • Take Accupril exactly as prescribed.
  • Accupril comes in tablet form and is taken once or twice daily.
  • Take Accupril on an empty stomach - one hour before, or two hours after a meal.
  • If you miss a dose, take the missed dose as soon as you remember. If it is almost time for the next dose, skip the missed dose and take your next dose at the regular time. Do not take two doses of Accupril at the same time.

Accupril Dosage

Take Accupril exactly as prescribed by your doctor. Follow the directions on your prescription label carefully.

High Blood Pressure: The recommended starting dose of Accupril for the treatment of high blood pressure is 10 mg or 20 mg once daily or divided into two smaller doses.

Congestive Heart Failure: The recommended starting dose of Accupril for the treatment of congestive heart failure is 5 mg twice a day.

Based on how your body responds to the medication and side effects you experience your healthcare provider may decide to increase or decrease your dose. The dose you receive is also based on the following factors:

  • your age
  • the medical condition you are being treated for
  • other medical conditions you may have 
  • other medications you are taking including diuretics

Accupril Overdose

If you take too much Accupril call your healthcare provider or poison control center, or seek emergency medical attention right away.

Other Requirements

Store at controlled room temperature between 15º–30ºC (59º–86ºF).

Keep this and all medications out of the reach of children.

Accupril FDA Warning


  • When pregnancy is detected, discontinue Accupril as soon as possible.
  • Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus.