Lioresal is used for spasticity due to various causes including multiple sclerosis. Stopping this medication too quickly can lead to withdrawal symptoms.

Lioresal Overview


Lioresal is a prescription medication used to relieve spasms and increased muscle tone caused by multiple sclerosis or spinal injury. This medication belongs to a group of drugs called muscle relaxants. Although the way it works is not fully understood, Lioresal may decrease the number and severity of muscle spasms by inhibiting nerve signals.

This medication comes in tablet form and are usually taken 3 or 4 times daily, with or without food.

This medication also comes as an injectable liquid to be given directly into the spinal fluid by a healthcare professional.

Common side effects include weakness, drowsiness, and dizziness. Do not drive or operate machinery until you know how this medication affects you.

Patient Ratings for Lioresal

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What are you taking Lioresal for?

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  • Other
  • Cerebral Palsy
  • Hiccup
  • Huntington Disease
  • Multiple Sclerosis
  • Muscle Spasticity
  • Myelitis, Transverse
  • Pain, Intractable
  • Spinal Cord Injuries
  • Spinal Cord Ischemia
  • Spinal Cord Neoplasms
  • Spondylolysis
  • Trigeminal Neuralgia
  • Urinary Bladder, Neurogenic

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  • A couple weeks
  • A month or so
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  • A year or so
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Lioresal Cautionary Labels


Uses of Lioresal

Lioresal is a prescription medication used to alleviate signs and symptoms of muscle spasms caused by multiple sclerosis or spinal cord injuries and other spinal cord diseases.

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.


Lioresal Drug Class

Lioresal is part of the drug class:

Side Effects of Lioresal

​Serious side effects have been reported. See "Lioresal Precautions" section.

Common side effects include:

  • drowsiness
  • dizziness
  • weakness
  • fatigue
  • headache
  • insomnia
  • nausea

Less common side effects include:

  • confusion
  • low blood pressure (hypotension)
  • constipation
  • frequent urination

This is not a complete list of Lioresal side effects. Ask your doctor or pharmacist for more information.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.


Lioresal Interactions

Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you take:

  • alcohol
  • benzodiazepines (drugs used to treat anxiety, panic attacks and other conditions) such as alprazolam (Xanax), chlordiazepoxide (Librium), clobazam (Onfi), clonazepam (Klonopin), diazepam (Valium), lorazepam (Ativan), temazepam (Restoril) and others
  • opioids (narcotic pain medicines) such as hydrocodone (in Lortab, in Vicodin), morphine (Avinza, Kadian, MS Contin, others), oxycodone (Oxycontin)
  • tricyclic antidepressants such as amitriptyline, amoxapine, desipramine (Norpramin), doxepin, imipramine (Tofranil), nortriptyline (Pamelor), protriptyline (Vivactil), and trimipramine (Surmontil)
  • sleep medicines such as eszopiclone (Lunesta), ramelteon (Rozerem), zaleplon (Sonata), zolpidem (Ambien)
  • muscle relaxants such as carisoprodol (Soma), cyclobenzaprine (Amrix, Flexeril), dantrolene (Dantrium) or metaxalone (Skelaxin)
  • other medicines that cause sedation

This is not a complete list of Lioresal drug interactions. Ask your doctor or pharmacist for more information.

Lioresal Precautions

Serious side effects have been reported including:

  • hallucinations and seizures after stopping medication too quickly. Withdrawal symptoms can occur if Lioresal is stopped too quickly. Talk to your doctor before stopping this medication, especially if you have been taking it for a long time. For intrathecal Lioresal, see "Lioresal FDA Warning" section.
  • increased risk of seizures. Lioresal can increase risk of seizures, especially in those with seizure disorders (epilepsy).
  • worsening mental illness. Talk to your doctor about mental illness.

Dose reduction may be necessary in patients with kidney disease. This medication is excreted by the kidneys. If you have kidney disease, your doctor may recommend a lower dose.

People who have suffered a stroke may be less able to tolerate baclofen and may not benefit from taking it.

Do not take Lioresal if you are allergic to any of its ingredients.

Lioresal can cause drowsiness. Do not drive or operate machinery until you know how it affects you.

Lioresal Food Interactions

Medications can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of Lioresal, there are no specific foods that you must exclude from your diet when receiving this medication.


Inform MD

Before taking Lioresal, tell your doctor about all of your medical conditions. Especially tell your doctor if you:

  • are allergic to any ingredient in Lioresal
  • have kidney disease
  • have epilepsy or seizures
  • have cerebral palsy
  • have Parkinson's disease
  • have a psychiatric condition
  • are pregnant or breastfeeding

Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements.


Lioresal and Pregnancy

Tell your doctor if you are pregnant or plan to become pregnant.

The FDA categorizes medications based on safety for use during pregnancy. Five categories - A, B, C, D, and X, are used to classify the possible risks to an unborn baby when a medication is taken during pregnancy.

Lioresal falls into category C. In animal studies, pregnant animals were given this medication and had some babies born with problems. No well-controlled studies have been done in humans, though. Therefore, this medication may be used if the potential benefits to the mother outweigh the potential risks to the unborn child.


Lioresal and Lactation

Tell your doctor if you are breastfeeding or plan to breastfeed.

Lioresal, when taken orally, has been detected in human breast milk. Because of the possibility for adverse reactions in nursing infants from Lioresal, a choice should be made whether to stop nursing or to stop use of this medication. The importance of the drug to the mother should be considered.


Lioresal Usage

Take Lioresal exactly as prescribed.


  • Lioresal comes in tablet form. It is usually taken 3 or 4 times daily, with or without food. 
  • If you miss a dose, take the missed dose as soon as you remember. If it is almost time for the next dose, skip the missed dose and take your next dose at the regular time. Do not take two doses of Lioresal at the same time.


  • Lioresal is also available in an injectable form to be used in more severe cases. It is given through a pump into the spinal fluid.

Lioresal Dosage

Take Lioresal exactly as prescribed by your doctor. Follow the directions on your prescription label carefully.

The Lioresal dose your doctor recommends will be based on the following:

  • the condition being treated
  • other medical conditions you have
  • other medications you are taking
  • how you respond to this medication


Your doctor will likely start you off on a low dosage and gradually increase your dose as necessary. The recommended dosage schedule is:

  • 5 mg three times daily for 3 days
  • 10 mg three times daily for 3 days
  • 15 mg three times daily for 3 days
  • 20 mg three times daily for 3 days

The maximum daily oral (by mouth) dose is 80 mg (20 mg four times daily).


A doctor will surgically place the pump that will deliver the dose of the medication. The dose of intrathecal Lioresal will be different for different patients and will depend on the type of muscle tightness that you have.


Lioresal Overdose

If you take too much this medication, call your healthcare provider or local Poison Control Center, or seek emergency medical attention right away.

If this medication is administered by a healthcare provider in a medical setting, it is unlikely that an overdose will occur. However, if overdose is suspected, seek emergency medical attention.

Other Requirements

  • Store at room temperature.
  • Keep this and all medications out of the reach of children.

Lioresal FDA Warning


Abrupt discontinuation of intrathecal (into the spine) Lioresal, regardless of the cause, has resulted in sequelae that include high fever, altered mental status, exaggerated rebound spasticity, and muscle rigidity, that in rare cases has advanced to rhabdomyolysis, multiple organ-system failure and death.  

Prevention of abrupt discontinuation of intrathecal Lioresal requires careful attention to programming and monitoring of the infusion system, refill scheduling and procedures, and pump alarms. Patients and caregivers should be advised of the importance of keeping scheduled refill visits and should be educated on the early symptoms of Lioresal withdrawal.  Special attention should be given to patients at apparent risk (e.g. spinal cord injuries at T-6 or above, communication difficulties, history of withdrawal symptoms from oral or intrathecal Lioresal). Consult the technical manual of the implantable infusion system for additional postimplant clinician and patient information.