Pamelor treats depression. Can cause weight gain and drowsiness. It is not recommended in those with certain heart conditions.

Pamelor Overview


Pamelor is a prescription medication used to treat the symptoms of depression. Pamelor belongs to a group of drugs called tricyclic antidepressants. These work by adjusting the levels of natural chemicals in the brain.

This medication comes in capsule form and is usually taken up to four times a day, with or without food.

Common side effects of Pamelor include nausea, weakness, and dry mouth.

Pamelor can also cause blurred vision, drowsiness, and dizziness. Do not drive or operate heavy machinery until you know how Pamelor affects you. 

Patient Ratings for Pamelor

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  • Other
  • Affective Disorders, Psychotic
  • Anxiety Disorders
  • Attention Deficit Disorder With Hyperactivity
  • Depressive Disorder
  • Enuresis
  • Pain

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Pamelor Cautionary Labels


Uses of Pamelor

Pamelor is a prescription medication used to treat the symptoms of depression.

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.


Side Effects of Pamelor

Serious side effects have been reported with Pamelor. See the "Drug Precautions" section.

Common side effects of Pamelor include the following:

  • nausea
  • drowsiness
  • dizziness
  • weakness
  • headache
  • nightmares
  • dry mouth
  • constipation
  • difficulty urinating
  • blurred vision
  • increased sweating
  • changes in sex drive
  • weight gain
  • changes in heart rhythm

This is not a complete list of Pamelor side effects. Ask your doctor or pharmacist for more information.

Tell your doctor if you have any side effect that bothers you or that does not go away.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Pamelor Interactions

Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements.

Especially tell your doctor if you take:

  • medications that use the enzyme CYP2D6 such as desipramine, dextromethorphan, atomoxetine, quinidine, propafenone and flecainide
  • medications that block a protein in the body (CYP2D6) such as quinidine (Qualaquin), fluoxetine (Prozac,Sarafem), amitriptyline (Elavil, Amitril, Amitid), and paroxetine (Paxil)
  • cimetidine (Tagamet)
  • reserpine
  • selective serotonin reuptake inhibitors (SSRIs) such as citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem), fluvoxamine (Luvox), paroxetine (Paxil), and sertraline (Zoloft)
  • MAOI's such as isocarboxazid (Marplan), phenelzine (Nardil), tranylcypromine (Parnate), and selegiline (Emsam, Eldepryl, Zelapar)
    rasagiline (Azilect)
  • linezolid (Zyvox)
  • triptans
  • fentanyl
  • lithium
  • tramadol
  • tryptophan
  • buspirone
  • St. John’s Wort

​Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

This is not a complete list of Pamelor drug interactions. Ask your doctor or pharmacist for more information.

Pamelor Precautions

Serious side effects have been reported with Pamelor including the following: 

  • Increase in suicidal thoughts. Antidepressant medicines may increase suicidal thoughts or actions in some children, teenagers, and young adults within the first few months of treatment. Tell your doctor right away if you notice new or sudden changes in mood, behavior, thoughts, or feelings. Call a healthcare provider right away if you or your family member has any of the following symptoms, especially if they are new, worse, or worry you:
    • thoughts about suicide or dying
    • attempts to commit suicide
    • new or worse depression
    • new or worse anxiety
    • feeling very agitated or restless
    • panic attacks
    • trouble sleeping (insomnia)
    • new or worse irritability
    • acting aggressive, being angry, or violent
    • acting on dangerous impulses
    • an extreme increase in activity and talking (mania)
    • other unusual changes in behavior or mood
  • Vision problems. Problems such as eye pain, changes in vision, swelling or redness in or around the eye can happen. 
  • Changes in blood sugar levels. Tell your doctor if you have diabetes. 
  • Serotonin Syndrome. Symptoms may include mental status changes such as agitation, hallucinations, delirium, fast heartbeat, dizziness, sweating, tremor, nausea, vomiting, and seizures. Serotonin Syndrome may happen if Pamelor is taken with other serotonergic drugs. 

​Avoid drinking alcohol while taking this medication. 

Do not take Pamelor if you:

  • are allergic to Pamelor or any of its ingredients
  • have had a heart attack
  • have taken a MAOI within 14 days

Pamelor Food Interactions

Medications can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of Pamelor, there are no specific foods that you must exclude from your diet when receiving this medication.

Inform MD

Before taking Pamelor, tell your doctor about all of your medical conditions. Especially tell your doctor if you:

  • are allergic to Pamelor and other tricyclic antidepressants such as desipramine (Norpramin), clomipramine (Anafranil), imipramine (Tofranil), trimipramine (Surmontil),any other medications, or any of the ingredients in nortriptyline capsules or liquid. Ask your doctor or pharmacist for a list of the ingredients.
  • are taking a monoamine oxidase (MAO) inhibitor such as isocarboxazid (Marplan), linezolid (Zyvox), methylene blue, phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), and tranylcypromine (Parnate), or if you have stopped taking an MAO inhibitor within the past 14 days. Your doctor will probably tell you not to take Pamelor. If you stop taking Pamelor, you should wait at least 14 days before you start to take an MAO inhibitor.
  • have recently had a heart attack. Your doctor may tell you not to take Pamelor.
  • have or have ever had an enlarged prostate (a male reproductive gland), difficulty urinating, diabetes, seizures, schizophrenia (a mental illness that causes disturbed or unusual thinking, loss of interest in life, and strong or inappropriate emotions), an overactive thyroid gland, or liver, kidney, or heart disease.
  • are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking Pamelor, call your doctor.
  • are having surgery, including dental surgery, tell the doctor or dentist that you are taking Pamelor.

Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements.

Pamelor and Pregnancy

Tell your doctor if you are pregnant or plan to become pregnant.

The FDA categorizes medications based on safety for use during pregnancy. Five categories - A, B, C, D, and X, are used to classify the possible risks to an unborn baby when a medication is taken during pregnancy.

Pamelor falls into category D. The safe use of Pamelor during pregnancy has not been established.

Pamelor and Lactation

The safe use of Pamelor during breastfeeding has not been established. Because of the possibility for adverse reactions in nursing infants from Pamelor, a choice should be made whether to stop nursing or to stop use of this medication. The importance of the drug to the mother should be considered.

Pamelor Usage

Take Pamelor exactly as prescribed.

Pamelor comes in capsule and an oral liquid to take by mouth once to four times a day and may be taken with or without food.

Your doctor will probably start you on a low dose of Pamelor and gradually increase your dose.

Continue to take Pamelor even if you feel well. Do not stop taking Pamelor without talking to your doctor. If you suddenly stop taking Pamelor, you may experience withdrawal symptoms such as headache, nausea, and weakness. Your doctor will probably want to decrease your dose gradually.

Your doctor may draw Pamelor levels to makes sure it is working and to avoid side effects. 

Pamelor Dosage

Take this medication exactly as prescribed by your doctor. Follow the directions on your prescription label carefully.

The recommended dose for adults is 25mg three or four times a day. The total daily dosage may be given once a day. The maximum daily dose above 150 mg is not recommended. 

The recommended dose in the elderly and in adolescent patients  is 30 to 50 mg per day, in divided doses, or the total daily dosage may be given once a day.

Pamelor Overdose

If you take too much Pamelor, call your healthcare provider or local Poison Control Center, or seek emergency medical attention right away.

Other Requirements

  • Store at 20° to 25°C (68° to 77°F).
  • Keep this medication and all other medications out of the reach of children. 

Pamelor FDA Warning

Suicidality and Antidepressant Drugs

Antidepressants increased the risk compared to placebo of suicidal thinking and behavior (suicidality) in children, adolescents, and young adults in short-term studies of major depressive disorder (MDD) and other psychiatric disorders. Anyone considering the use of Pamelor or any other antidepressant in a child, adolescent, or young adult must balance this risk with the clinical need. Short-term studies did not show an increase in the risk of suicidality with antidepressants compared to placebo in adults beyond age 24; there was a reduction in risk with antidepressants compared to placebo in adults aged 65 and older. Depression and certain other psychiatric disorders are themselves associated with increases in the risk of suicide. Patients of all ages who are started on antidepressant therapy should be monitored appropriately and observed closely for clinical worsening, suicidality, or unusual changes in behavior. Families and caregivers should be advised of the need for close observation and communication with the prescriber. Pamelor is not approved for use in pediatric patients.