Dantrium

Dantrium relieves spasms and increases muscle tone caused by multiple sclerosis, stroke, or brain or spinal injury. May cause drowsiness. Do not drive until you know how it affects you.

Dantrium Overview

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Dantrium is a prescription medication used to relieve spasms and increased muscle tone caused by multiple sclerosis, stroke, or brain or spinal injury. Dantrium belongs to a group of drugs called muscle relaxants. Dantrium causes muscle relaxation by interfering with calcium release within the muscle.

This medication comes in the form of a capsule and a liquid for injection. The capsule is usually taken by mouth 3 or 4 times daily. The injection is given directly into a vein (IV) by a healthcare provider.

Common side effects include diarrhea, drowsiness, and dizziness. Do not drive or operate machinery until you know how it affects you. It is best to avoid alcohol while taking Dantrium.

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  • Other
  • Cerebral Infarction
  • Cerebral Palsy
  • Malignant Hyperthermia
  • Multiple Sclerosis
  • Muscle Spasticity
  • Neuroleptic Malignant Syndrome
  • Spinal Cord Injuries

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Dantrium Cautionary Labels

precautionsprecautionsprecautionsprecautions

Uses of Dantrium

Dantrium is a prescription medication, which in capsule form, is used to relieve spasms and increased muscle tone caused by multiple sclerosis, stroke, or brain or spinal injury.

Dantrium capsules and injection are both approved to treat or prevent malignant hyperthermia, an inherited, potentially fatal condition in which body temperature quickly rises and severe muscle contraction occurs when the affected person receives anesthesia during surgery.

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

Manufacturer

Dantrium Drug Class

Dantrium is part of the drug class:

Side Effects of Dantrium

Oral Capsules:

Common side effects include:

  • drowsiness
  • dizziness
  • weakness
  • feeling of discomfort (malaise)
  • fatigue
  • diarrhea
  • loss of grip strength and weakness in the legs (particularly when Dantrium is given by IV injection)

Injection:

Common side effects include:

  • drowsiness
  • dizziness
  • loss of grip strength and weakness in the legs (particularly when dantrolene is given by IV injection)
  • injection site reactions
  • pulmonary edema
  • hives

This is not a complete list of Dantrium side effects. Ask your doctor or pharmacist for more information.

Serious side effects have been reported. See "Drug Precautions" section.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Dantrium Interactions

Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you take:

  • alcohol
  • baclofen (Lioresal)
  • estrogen
  • benzodiazepines (drugs used to treat anxiety, panic attacks and other conditions) such as alprazolam (Xanax), chlordiazepoxide (Librium), clobazam (Onfi), clonazepam (Klonopin), diazepam (Valium), lorazepam (Ativan), temazepam (Restoril) and others
  • calcium channel blocker medications such as verapamil (Calan, Covera HS, Verelan) and others
  • opioids (narcotic pain medicines) such as hydrocodone (in Lortab, in Vicodin), morphine (Avinza, Kadian, MS Contin, others), oxycodone (Oxycontin)
  • tricyclic antidepressants such as amitriptyline, amoxapine, desipramine (Norpramin), doxepin, imipramine (Tofranil), nortriptyline (Pamelor), protriptyline (Vivactil), and trimipramine (Surmontil)
  • sleep medicines such as eszopiclone (Lunesta), ramelteon (Rozerem), zaleplon (Sonata), zolpidem (Ambien)
  • other medicines that cause sedation
  • medications for seizures, allergies, colds, or coughs
  • warfarin (Coumadin, Jantoven)

This is not a complete list of Dantrium drug interactions. Ask your doctor or pharmacist for more information.

Dantrium Precautions

Serious side effects may occur including:

  • liver injury. The risk of liver injury appears to be greater in females, in patients over 35 years of age, and in patients taking other medication. Your doctor may monitor your liver function while you are taking this medication.
  • drowsiness. Dantrium can cause drowsiness, especially when used with alcohol. Do not drive or operate machinery until you know how this medication affects you.
  • cancer or tumors. Some animals treated with Dantrium for prolonged periods at high doses developed tumors and cancers. It is not known if this medication can cause these effects in humans.
  • swallowing problems. Dantrium injection has been reported to cause difficulty swallowing.
  • increased risk of sunburn and other sun reactions to skin. Avoid unnecessary or prolonged exposure to sunlight and to wear protective clothing, sunglasses, and sunscreen. Dantrium may make your skin sensitive to sunlight.

Do not take Dantrium if you:

  • are allergic to any component of this medication
  • have liver disease
  • are unable to maintain balance and upright posture while walking without muscle spasticity

Dantrium Food Interactions

Medications can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of Dantrium, there are no specific foods that you must exclude from your diet when receiving this medication.

Inform MD

Before taking Dantrium, tell your doctor about all of your medical conditions. Especially tell your doctor if you:

  • are allergic to any ingredient in Dantrium
  • have liver, heart, rheumatic, or lung disease
  • have had seizures or epilepsy
  • are pregnant or breastfeeding

Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements.

Dantrium and Pregnancy

Tell your doctor if you are pregnant or plan to become pregnant.

The FDA categorizes medications based on safety for use during pregnancy. Five categories - A, B, C, D, and X, are used to classify the possible risks to an unborn baby when a medication is taken during pregnancy.

Dantrium falls into category C. There are no adequate and well-controlled studies in pregnant women. Dantrolene should be given to a pregnant woman only if clearly needed.

Dantrium and Lactation

Tell your doctor if you are breastfeeding or plan to breastfeed.

Dantrium has been detected in human breast milk. Because of the possibility for adverse reactions in nursing infants from Dantrium, a choice should be made whether to stop nursing or to stop use of this medication. The importance of the drug to the mother should be considered.

Dantrium Usage

Take Dantrium exactly as prescribed.

  • Dantrium comes in capsule form, as well as in an injectable form to be given directly into a vein by a healthcare provider.
  • Dantrium capsules are usually taken 3 or 4 times daily.
  • Dantrium can be taken with or without food. If it bothers your stomach try taking it with food.
  • If you miss a dose, take the missed dose as soon as you remember. If it is almost time for the next dose, skip the missed dose and take your next dose at the regular time. Do not take two doses of Dantrium at the same time.

Dantrium Dosage

Take Dantrium exactly as prescribed by your doctor. Follow the directions on your prescription label carefully.

The Dantrium dose your doctor recommends will be based on the following:

  • the condition being treated
  • other medical conditions you have
  • other medications you are taking
  • how you respond to this medication
  • how you are receiving Dantrium (orally or intravenously)
  • your weight
  • your age

​The maximum recommended dose of oral Dantrium (dantrolene) is 100 mg taken 4 times daily. Your doctor will start you at a low dose then titrate you up to a dose that works for you. 

The recommended dose of Dantrium (dantrolene) injection for malignant hyperthermia is 2.5 mg/kg given through the vein (IV) and will continue until the symptoms resolve or the maximum dose of 10 mg/kg is met. 

Dantrium Overdose

If you take too Dantrium much call your healthcare provider or local Poison Control Center, or seek emergency medical attention right away.

If Dantrium is administered by a healthcare provider in a medical setting, it is unlikely that an overdose will occur. However, if overdose is suspected, seek emergency medical attention.

Other Requirements

  • Store Dantrium capsules at room temperture between 20° to 25°C (68° to 77°F).
  • Keep this and all medications out of the reach of children.

Dantrium FDA Warning

Dantrium has a potential for hepatotoxicity, and should not be used in conditions other than those recommended. Symptomatic hepatitis (fatal and non-fatal) has been reported at various dose levels of the drug. The incidence reported in patients taking up to 400 mg/day is much lower than in those taking doses of 800 mg or more per day. Even sporadic short courses of these higher dose levels within a treatment regimen markedly increased the risk of serious hepatic injury. Liver dysfunction as evidenced by blood chemical abnormalities alone (liver enzyme elevations) has been observed in patients exposed to Dantrium for varying periods of time. Overt hepatitis has occurred at varying intervals after initiation of therapy, but has been most frequently observed between the third and twelfth month of therapy. The risk of hepatic injury appears to be greater in females, in patients over 35 years of age, and in patients taking other medication(s) in addition to Dantrium. Spontaneous reports suggest a higher proportion of hepatic events with fatal outcome in elderly patients receiving Dantrium. However, the majority of these cases were complicated with confounding factors such as intercurrent illnesses and/or concomitant potentially hepatotoxic medications. Dantrium should be used only in conjunction with appropriate monitoring of hepatic function including frequent determination of SGOT or SGPT. If no observable benefit is derived from the administration of Dantrium after a total of 45 days, therapy should be discontinued. The lowest possible effective dose for the individual patient should be prescribed.