Zofran

Zofran is a prescription medication used to prevent nausea and vomiting caused by chemotherapy or surgery. Zofran belongs to a group of drugs called serotonin 5-HT3 antagonists, which block serotonin, a natural chemical in the body, from causing nausea and vomiting.

This medication comes in several oral forms: tablets and and solution (liquid). Zofran is also available in an injectable form to be given directly into a vein (IV) by a healthcare professional.

The first oral dose of Zofran is usually taken 30 minutes before the start of chemotherapy, 1 to 2 hours before the start of radiation therapy, or 1 hour before surgery.

Common side effects include headache, tiredness, and constipation. Zofran can cause dizziness. Do not drive or operate heavy machinery until you know how it affects you.

Zofran is a prescription medication used for the:

• prevention of nausea and vomiting associated with chemotherapy
• prevention of nausea and vomiting caused by radiation therapy
• prevention of nausea and vomiting caused by surgery 

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

Take Zofran exactly as prescribed by your doctor. Follow the directions on your prescription label carefully.

Surgery

The recommended Zofran dose for preventing nausea and vomiting after surgery is 16 mg taken one hour before anesthesia is administered.

Chemotherapy

High-risk (for nausea and vomiting) chemotherapy: The dose of Zofran for high-risk chemotherapy is 24 mg 30 minutes before chemotherapy.

Medium-risk (for nausea and vomiting) chemotherapy: The dose of Zofran for medium-risk chemotherapy is 8 mg twice daily.

• The first dose should be taken 30 minutes before chemotherapy.
• The second dose should be taken eight hours after the first dose.
• After that, Zofran should be taken twice a day (about every 12 hours) until one to two days after chemotherapy.

​Radiation

The recommended oral dosage of Zofran is one 8 mg given 3 times a day.

Total body irradiation: The dose of Zofran for total body irradiation is 8 mg taken one to two hours before radiotherapy each day of radiation treatment.

Single high-dose fraction radiotherapy to the abdomen:The recommended dose is 8 mg taken one to two hours before radiotherapy followed by 8 mg every eight hours until one to two days after radiation.

Daily fractionated radiotherapy to the abdomen: The recommended dose is 8 mg taken each day one to two hours before radiotherapy, with subsequent doses every 8 hours after the first dose for each day radiotherapy is given.

Dose in Patients with Liver Disease

The dose of Zofran is decreased for people who have poor liver function (hepatic function). People with severely impaired liver function should not take more than 8 mg Zofran total each day.

Serious side effects have been reported with Zofran including:

• hypotension. Zofran and apomorphine (Apokyn) should not be taken at the same time as there is a risk of dangerously low blood pressure and loss of consciousness.
• severe allergic reactions. Hypersensitivity (allergic) reactions have been reported in patients who are allergic to other selective 5-HT3 receptor antagonists.
• changes in heart rhythm. ECG changes including QT interval prolongation has been seen in patients receiving Zofran. 
• masking symptoms of intestinal blockage. Using Zofran after abdominal surgery or chemotherapy may mask the symptoms of an intestinal blockage (abdominal ileus). 

Do not take Zofran if you:

• are allergic to Zofran or any ingredient in it
• are taking apomorphine (Apokyn)
• have long QT syndrome (condition that increases the risk of developing an irregular heartbeat that may cause fainting or sudden death)

Zofran can cause drowsiness. Do not drive or operate heavy machinery until you know how Zofran affects you.

Zofran can cause serious side effects. See "Drug Precautions" section.

Common side effects include:

• headache
• tiredness
• constipation
• diarrhea
• dizziness

This is not a complete list of Zofran side effects. Ask your doctor or pharmacist for more information.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you take:

• apomorphine (Apokyn)
• medications for irregular heart beat
• carbamazepine (Carbatrol, Epitol, Equetro, Tegretol)
• phenytoin (Dilantin, Phenytek)
• rifampicin (Rifadin)
• tramadol (Rybix, Rybix ODT, Ultram, Ultram ER)

This is not a complete list of Zofran drug interactions. Ask your doctor or pharmacist for more information.

Tell your doctor if you are pregnant or plan to become pregnant.

The FDA categorizes medications based on safety for use during pregnancy. Five categories - A, B, C, D, and X, are used to classify the possible risks to an unborn baby when a medication is taken during pregnancy.

Zofran falls into category B. There are no good studies that have been done in humans with Zofran. But in animal studies, pregnant animals were given this medication, and the babies did not show any medical issues related to this medication.

It is not known if Zofran crosses into human milk. Because many medications can cross into human milk and because of the possibility for serious adverse reactions in nursing infants with use of this medication, a choice should be made whether to stop nursing or stop the use of this medication. Your doctor and you will decide if the benefits outweigh the risk of using Zofran.

Tell your doctor if you have phenylketonuria (PKU). The orally disintegrating tablets (ondansetron ODT) contain aspartame that forms phenylalanine.

The first oral dose of ondansetron is usually taken 30 minutes before the start of chemotherapy, 1 to 2 hours before the start of radiation therapy, or 1 hour before surgery.

For ondansetron orally disintegrating tablets (ODTs), you should keep each tablet in its original blister pack until you need it. Do not try to push the tablet through the foil (the tablet is delicate and would be crushed). Instead, gently peel the foil away and remove the tablet.