Refissa

Refissa is a prescription medication used to reduce fine facial wrinkles and darkening of skin (hyperpigmentation). Refissa belongs to a group of drugs called retinoids. It is not known exactly how it works to reduce fine facial wrinkles. 

Refissa comes in a cream and is applied to the face once a day at bedtime. 

Common side effects of Refissa include peeling, dry skin, and redness of the skin.

Refissa is a prescription medication that may reduce fine wrinkles and darkening of skin (hyperpigmentation). It is for patients who are using a total skin care and sunlight avoidance program. Refissa does not remove wrinkles or repair sun-damaged skin. 

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

Apply a pea-sized amount of cream to cover your entire face. Apply this medication once daily at bedtime. 

Do not use Refissa if:

• you are pregnant or plan to become pregnant
• you are sunburned or your skin is irritated
• you are highly sensitive to sunlight
• have eczema or other skin conditions
• you are allergic to any of the ingredients in the Refissa

Exposure to sunlight (including sunlamps) should be avoided or minimized during use of Refissa use because of heightened sunburn susceptibility.

Refissa has been reported to cause severe irritation to patients with eczema and should be used only with caution if you have this particular skin condition.

Avoid contact with the eyes, ears, nostrils, angles of the nose, and mouth. Refissa may cause severe redness, itching, burning, stinging, and peeling if used on these areas.

Avoid excessive exposure to wind or cold. Extremes of climate tend to dry or burn normal skin. Skin treated with Refissa may be more vulnerable to these extremes. Your physician can recommend ways to manage your acne treatment under such conditions.

Common side effects of Refissa include peeling, dry skin, redness of the skin, burning, stinging, and itching.

This is not a complete list of Refissa side effects. Ask your doctor or pharmacist for more information.

Tell your doctor if you have any side effect that bothers you or that does not go away.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you take:

• thiazide diuretics
• tetracycline antibiotics such as demeclocycline (Declomycin), doxycycline (Monodox, Vibramycin, others), minocycline (Minocin), oxytetracycline (Terramycin), and tetracycline (Sumycin, Tetrex, others)
• fluoroquinolone antibiotics
• ketoconazole (Nizoral)
• phenothiazine medications
• sulfonamide-containing medications
• aminocaproic acid (Amicar)
• certain calcium channel blockers such as diltiazem (Cardizem, Dilacor, Tiazac, others) and verapamil (Calan, Covera, Isoptin, Verelan)
• cimetidine (Tagamet)
• cyclosporine (Sandimmune, Gengraf, Neoral)
• erythromycin (E.E.S., Erythrocin, E-Mycin)
• hydroxyurea (Droxia)
• pentobarbital
• phenobarbital
• rifampin (Rifadin, Rimactane)
• oral steroids such as dexamethasone (Decadron, Dexone), methylprednisolone (Medrol), and prednisone (Deltasone)
• tranexamic acid (Cyklokapron)
• vitamin A

This is not a complete list of all drug interactions. Ask your doctor or pharmacist for more information.

You should avoid using skin products that can dry or irritate your skin because skin dryness and irritation are increased with Refissa. Skin products that can dry and irritate your skin include:

• products that contain alcohol, astringents, or spices
• acne medicines that contain benzoyl peroxide, sulfur, resorcinol, or salicylic acid
• medicated soap or skin cleansers

This is not a complete list of all drug interactions. Ask your doctor or pharmacist for more information.

Tell your doctor if you are pregnant or plan to become pregnant.

• The FDA categorizes medications based on safety for use during pregnancy. Five categories - A, B, C, D, and X, are used to classify the possible risks to an unborn baby when a medication is taken during pregnancy.
• This medication falls into category C. Do not use Refissa if you are pregnant or attempting to become pregnant. If you become pregnant while using Refissa, please contact your doctor immediately.

Tell your doctor if you are breastfeeding or plan to breastfeed.

It is not known if this medication crosses into human milk. Because many medications can cross into human milk and because of the possibility for serious adverse reactions in nursing infants with use of this medication, a choice should be made whether to stop nursing or stop the use of this medication. Your doctor and you will decide if the benefits outweigh the risk of using this medication.

Do not use tretinoin if you are pregnant or attempting to become pregnant.

Two forms of reliable contraception must be used during therapy, and must be continued for one month after tretinoin treatment has stopped.

Tretinoin should not be taken by nursing mothers since it is not known whether it is excreted in human milk.

Use a skin moisturizer at least every morning to protect the treated areas from dryness.

Use sunscreen and wear protective clothing to protect the treated areas from sunlight.