Prefest is a prescription medication used after menopause to reduce moderate to severe hot flashes, treat moderate to severe menopausal changes in and around the vagina, and help reduce your chances of getting osteoporosis (thin weak bones). Prefest contains two hormones, estradiol and norgestimate, and belongs to a group of drugs called estrogen and progestin combinations. Prefest works as a hormone replacement to relieve issues caused by hormonal changes. 

Prefest comes in tablet form and is usually taken once daily, with or without food. 

Common side effects of Prefest include headache, breast pain, and irregular vaginal bleeding or spotting.

Estrogens increase the chance of getting cancer of the uterus.

Do not use estrogens to prevent heart disease, heart attacks, or strokes.