Pegaptanib

Pegaptanib is a prescription medication used to treat wet age-related macular degeneration (AMD).

Pegaptanib belongs to a group of drugs called vascular endothelial growth factor (VEGF) antagonists. These work by stopping abnormal blood vessel growth and leakage in the eye(s) that may cause vision loss in people with wet age-related macular degeneration (AMD).

This medication is available in an injectable form to be given directly into the eye by a healthcare professional once every six weeks.

Common side effects of pegaptanib include punctate keratitis (inflammation on the surface of the cornea), vitreous floaters or  opacities (small particles in the field of vision), eye pain, and increased intraocular pressure (pressure inside the eye). 

Pegaptanib can also cause blurred vision and dizziness. Do not drive or operate heavy machinery until you know how pegaptanib affects you.

Pegaptanib is a prescription medication used to treat wet age-related macular degeneration (AMD).

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

The recommended dose of Macugen (pegaptanib) is 0.3 mg and is injected into the eye once every six weeks.

Serious side effects have been reported with pegaptanib including the following:

• Endophthalmitis (inflammation of the inner coats of the eye due to an infection). In the days following pegaptanib administration, patients are at risk for developing endophthalmitis. Please seek immediate medical care If you experience any of the following: eye redness, sensitivity to light, eye pain, or changes in vision. 
• Increases in intraocular pressure. Increases in the pressure inside the eye have been seen within 30 minutes of injection with pegaptanib. Your doctor should monitor you appropriately. 
• Anaphylaxis (severe allergic reaction): Please seek immediate medical care if you experience any of the following soon after the injection: sudden onset of breathing difficulty or wheezing, swollen mouth, face, hands or feet, itching skin, fainting, rapid pulse, stomach cramps, nausea, vomiting and diarrhea.

Pegaptanib can cause blurred vision and dizziness. Do not drive or operate heavy machinery until you know how pegaptanib affects you.

Do not take pegaptanib if you:

• are allergic to pegaptanib or to any of its ingredients 
• have an eye infection in or around the eye 

Serious side effects have been reported with pegaptanib. See the “Pegaptanib Precautions” section.

Common side effects of pegaptanib include the following:

• anterior chamber inflammation (inflammation of the fluid-filled space between the iris, the colored part of the eye and the clear outer layer of the eye, cornea) 
• blurred vision 
• cataract (clouding of the lens of the eye) 
• conjunctival hemorrhage (bloodshot eye) 
• corneal edema (swelling of the clear outer layer of the eye) 
• eye discharge
• eye irritation
• eye pain
• high blood pressure
• increased intraocular pressure (pressure inside the eye)
• eye discomfort
• punctate keratitis (inflammation of the surface of the cornea, clear outer layer of the eye) 
• reduced visual acuity
• visual disturbances
• vision loss
• vitreous floaters or opacities (small particles in the field of vision)

This is not a complete list of pegaptanib side effects. Ask your doctor or pharmacist for more information.

Tell your doctor if you have any side effect that bothers you or that does not go away.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

No drug interactions have been studied by the manufacturer. However, you should tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements. Not all drug interactions are known or reported and new drug interactions are continually being reported.

Tell your doctor if you are breastfeeding or plan to breastfeed.

It is not known if pegaptanib crosses into human milk. Because many medications can cross into human milk and because of the possibility for serious adverse reactions in nursing infants with use of this medication, a choice should be made whether to stop nursing or stop the use of this medication. Your doctor and you will decide if the benefits outweigh the risk of using pegaptanib. 

The injection is given into the vitreous of the eye, the jelly-like substance inside the eye.

Before you receive a pegaptanib injection, your doctor will clean and numb your eye. After that you should not feel the injection, which is a simple and rapid procedure.

You may experience temporary visual blurring after receiving pegaptanib. Do not drive or operate heavy machinery until you know how pegaptanib affects you and/or it resolves.

Keep all appointments with your doctor. Your doctor will need to examine your eyes to see if you are developing serious side effects during the week following the injection.