Mefloquine

Mefloquine is a prescription medication used to prevent and treat malaria. Mefloquine belongs to a group of drugs called antimalarials, which work by killing the parasite that causes malaria.

This medication comes in tablet form and is taken once a day with food and with one cup (8 ounces) of water.

Common side effects of mefloquine include nausea, vomiting, and stomach pain. Mefloquine can also cause dizziness. Do not drive or operate heavy machinery until you know how mefloquine affects you.

Mefloquine is a prescription medication used to prevent and treat malaria.

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

Take mefloquine exactly as prescribed by your doctor. Follow the directions on your prescription label carefully.

The mefloquine dose your doctor recommends will be based on the following:

• the condition being treated
• your age

The recommended dose for mefloquine in adults for the prevention of malaria is one tablet (250 mg) once weekly.

The recommended dose for mefloquine in adults for the treatment of malaria is 5 tablets (1250 mg) to be given as a single dose.

The recommended dose range for mefloquine in children (weighing 20 kg or greater) for the prevention of malaria is based on the child’s body weight.

• Over 45 kg: take one whole tablet (250 mg)
• 30 to 45 kg: take 3/4 of a tablet (187.5 mg)
• 20 to 30 kg: take 1/2 of a tablet (125 mg)

The recommended dose range for mefloquine in children (weighing 20 kg or greater) for the treatment of malaria is 20 to 25 mg/kg. Splitting the total dose into 2 doses taken 6 to 8 hours apart may reduce the occurrence or severity of adverse effects. This dose should not exceed the adult dose.

Mefloquine may cause neuropsychiatric adverse reactions that can persist after mefloquine has been discontinued.

Mefloquine should not be prescribed for prophylaxis in patients with major psychiatric disorders. During prophylactic use, if psychiatric or neurologic symptoms occur, the drug should be discontinued and an alternative medication should be substituted.

Serious side effects have been reported with mefloquine including the following:

• heart problems. Do not take halofantrine (Halfan) or ketoconazole (Nizoral) with mefloquine or within 15 weeks of your last dose of mefloquine. You may get serious heart problems (problems with the electrical system of your heart called QT prolongation) that can lead to death. Do not take quinine (Qualaquin) or quinidine (Cardioquine, Quinact, Duraquin) with mefloquine. You may get serious heart problems.
• mental problems. Symptoms of serious mental problems may include:
  • severe anxiety
  • paranoia (feelings of mistrust towards others)
  • hallucinations (seeing or hearing things that are not there)
  • depression
  • feeling restless
  • unusual behavior
  • feeling confused

Some people who take mefloquine think about suicide (putting an end to their life). Some people who were taking mefloquine committed suicide. It is not known if mefloquine was responsible for those suicides.

If you have any of these serious mental problems, or you develop other serious side effects or mental problems, you should contact your doctor right away as it may be necessary to stop taking mefloquine and use a different medicine to prevent malaria.

• problems with your body’s nervous system. Symptoms of serious nervous system problems may include:
  • dizziness
  • a feeling that you or things around you are moving or spinning (vertigo)
  • loss of balance
  • ringing sound in your ears (tinnitus)
  • convulsions (seizures) in people who already have seizures (epilepsy)
  • convulsions (seizures) in people who take quinine (Qualaquin) or chloroquine (Aralen) with mefloquine. Do not take quinine or chloroquine with mefloquine.
  • unable to sleep (insomnia)

Dizziness, vertigo, tinnitus, and loss of balance can go on for months or years after mefloquine is stopped or may become permanent in some people. Do not drive or operate heavy machinery until you know how mefloquine affects you.

Do not take mefloquine if you:

• are allergic to mefloquine or to any of its ingredients
• have or have had depression recently
• had recent mental problems, including anxiety disorder, schizophrenia, or psychosis (losing touch with reality)

• seizures or had seizures (epilepsy or convulsions)
• an allergy to quinine (Qualaquin) or quinidine (Cardioquine, Duraquin)

Serious side effects have been reported with mefloquine. See the “Drug Precautions” section.

Common side effects of mefloquine include the following:

• nausea
• vomiting
• diarrhea
• stomach pain
• headache
• muscle pain
• fever
• chills
• skin rash
• fatigue
• loss of appetite
• irregular heart beat

This is not a complete list of mefloquine side effects. Ask your doctor or pharmacist for more information.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you take:

• medications that block the enzyme CYP3A4 such as some macrolide antibiotics (clarithromycin, telithromycin), some HIV protease inhibitors (indinavir, nelfinavir, ritonavir, saquinavir), some HCV protease inhibitors (boceprevir, telaprevir), some azole antifungals (ketoconazole, itraconazole, posaconazole, voriconazole), conivaptan (Vaprisol), delavirdine (Rescriptor), and nefazodone (Serzone)
• medications that increase the activity of the enzyme CYP3A4 such as carbamazepine (Tegretol, Equetro, Carbatrol), phenobarbital, phenytoin (Dilantin), rifampin (Rifadin), St John's wort, and nimodipine (Nimotop)
• medications that block the p-glycoprotein transporter such as amiodarone (Cordarone, Pacerone), azithromycin (Zithromax, Zmax), captopril (Capoten), carvedilol (Coreg), clarithromycin (Biaxin), conivaptan (Vaprisol), cyclosporine (Neoral, Sandimmune, Gengraf), diltiazem (Cardizem), dronedarone (Multaq), erythromycin (EES, Ery-Tab), felodipine (Plendil), itraconazole (Sporanox, Onmel), ketoconazole (Nizoral), lopinavir and ritonavir (Kaletra), quinidine (Cardioquine, Duraquin), ranolazine (Ranexa), verapamil (Calan, Isoptin, Covera, Verelan)
• medications that use the p-glycoprotein transporter such as digoxin (Lanoxin), loperamide (Imodium), quinidine (Cardioquine, Duraquin), vinblastine (Velban), fexofenadine (Allegra), indinavir (Crixivan), colchicine (Colcrys), topotecan (Hycamtin), and paclitaxel (Abraxane, Onxol, Taxol)
• beta blockers such as metoprolol (Toprol XL, Lopressor), carvedilol (Coreg), bisoprolol (Zebeta), betaxolol (Kerlone), nebivolol (Bystolic), and propranolol (Inderal)
• calcium channel blockers such as nifedipine (Adalat, Nifedical, Procardia), amlodipine (Norvasc), verapamil (Calan, Isoptin, Covera, Verelan), and diltiazem (Cardizem)
• anti-arrhythmia medications such as procainamide (Procanbid, Procan), disopyramide (Norpace, Rythmodan), lidocaine (Xylocaine, Lidoderm), phenytoin (Dilantin), mexiletine (Mexitil), flecainide (Tambocor), propafenone (Rythmol), amiodarone (Cordarone, Pacerone), sotalol (Betapace), dofetilide (Tikosyn), dronedarone (Multaq), digoxin (Lanoxin), and adenosine (Adenocard)
• valproic acid (Depakene, Depakote, Stavzor)
• halofantrine (Halfan)
• chloroquine (Aralen)

This is not a complete list of mefloquine drug interactions. Ask your doctor or pharmacist for more information.

Tell your doctor if you are pregnant or plan to become pregnant.

The FDA categorizes medications based on safety for use during pregnancy. Five categories - A, B, C, D, and X, are used to classify the possible risks to an unborn baby when a medication is taken during pregnancy.

Mefloquine falls into category B. It is not known if mefloquine will harm your unborn baby. Talk to your doctor if you are pregnant or plan to become pregnant.

You should use birth control while you take mefloquine and for 3 months after you stop mefloquine. If you have an unplanned pregnancy, talk to your doctor right away.

Tell your doctor if you are breastfeeding or plan to breastfeed.

Mefloquine has been detected in human breast milk. Because of the possibility for adverse reactions in nursing infants from mefloquine, a choice should be made whether to stop nursing or to stop use of mefloquine. The importance of the drug to the mother should be considered.

You should use birth control while you take mefloquine and for 3 months after you stop mefloquine.

Do not take mefloquine on an empty stomach. Take just after the largest meal of the day and with one cup (8 ounces) of water.

You will still need to take malaria prevention medicine for another 4 weeks after you leave the malaria area.

Mefloquine does not work for all types of malaria.