Ibandronate

Ibandronate is a prescription medication used to treat or prevent the thinning of bones, known medically as osteoporosis, in postmenopausal women. Ibandronate belongs to a group of drugs called bisphosphonates, which slow the breakdown of bone.

This medication comes in tablet form. It is taken once a month, on an empty stomach with a glass of water. 

This medication is also available in an injectable form to be given directly into a vein (IV) by a healthcare professional.

Common side effects include back pain, heartburn, and abdominal (stomach area) pain.

Oral:

• Ibandronate is a prescription medicine used to treat or prevent osteoporosis (thinning of bones and increased risk of bones breaking). It is used in women who have gone through menopause (the end of menstrual periods).
• This medication may be prescribed for other uses.  Ask your doctor or pharmacist for more information.

Injectable:

• Ibandronate is a prescription medicine used to treat or prevent osteoporosis (thinning of bones and increased risk of bones breaking).
• This medication may be prescribed for other uses.  Ask your doctor or pharmacist for more information.

Take ibandronate exactly as your doctor has prescribed it. Carefully follow the directions on your prescription label.

Oral:

• The ibandronate 2.5 mg tablet is taken once daily.
• The ibandronate 150 mg tablet should be taken once on the same date each month. 
• The recommended dose of ibandronate injection for postmenopausal osteoporosis is 3 mg every 3 months.

Injectable:

• This medication is available in an injectable form to be dosed by a healthcare professional.

Oral/Injectable:

Ibandronate can cause serious side effects including:

1. Esophagus problems
2. Low calcium levels in your blood (hypocalcemia)
3. Bone, joint or muscle pain
4. Severe jaw bone problems (osteonecrosis)
5. Unusual thigh bone fractures

• It is important that you take ibandronate exactly as prescribed to help lower your chance of getting esophagus problems.
• Stop taking ibandronate and call your doctor right away if you get chest pain, new or worsening heartburn, or have trouble or pain when you swallow.

• Spasms, twitches, or cramps in your muscles
• Numbness or tingling in your fingers, toes, or around your mouth

Call your doctor right away if you have any of these side effects.

Do not take ibandronate if you:

• Have certain problems with your esophagus, the tube that connects your mouth with your stomach
• Cannot stand or sit upright for at least 60 minutes
• Have low levels of calcium in your blood
• Are allergic to ibandronate or any of its ingredients

Oral/Injectable:

Ibandronate may cause serious side effects. See "Ibandronate Precautions".

Common side effects include:

• Back pain
• Heartburn
• Stomach area (abdominal) pain
• Pain in your arms and legs
• Diarrhea
• Headache
• Muscle pain
• Flu-like symptoms

You may get allergic reactions, such as hives or, in rare cases, swelling of your face, lips, tongue or throat.

Tell your doctor if you have any side effect that bothers you or that does not go away.

These are not all the possible side effects of ibandronate. For more information, ask your doctor or pharmacist.

Tell your doctor about all the medicines you take or plan to take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you take:

• aspirin
• ibuprofen (Motrin, Advil)
• other NSAIDS (non-steroidal anti-inflammatory drugs) 
• antacids, supplements, or medicines containing aluminum, calcium, or magnesium

This is not a complete list of ibandronate drug interactions. Ask your doctor or pharmacist for more information.

Tell your doctor if you are pregnant or plan to become pregnant.

The FDA categorizes medications based on safety for use during pregnancy. Five categories - A, B, C, D, and X, are used to classify the possible risks to an unborn baby when a medication is taken during pregnancy.

Ibandronate falls into category C. In animal studies, pregnant animals were given this medication and had some babies born with problems. No well-controlled studies have been done in humans, though. Therefore, this medication may be used if the potential benefits to the mother outweigh the potential risks to the unborn child.

It is not known if ibandronate crosses into human milk. Because many medications can cross into human milk and because of the possibility for serious adverse reactions in nursing infants with use of this medication, a choice should be made whether to stop nursing or stop the use of this medication. Your doctor and you will decide if the benefits outweigh the risk of using ibandronate.

Take 1 ibandronate tablet after you get up for the day and before taking your first food, drink, or other medicine.

Do not chew or suck on a tablet of ibandronate.

Swallow ibandronate tablet with a full glass (6-8 oz) of plain water only.

Take ibandronate while you are sitting or standing.

After swallowing ibandronate tablet, wait at least 60 minutes before:

• lying down. You may sit, stand or walk, and do normal activities like reading.
• you take your first food or drink except for plain water
• you take other medicines, including antacids, calcium, and other supplements and vitamins