Adlyxin

Adlyxin is a prescription medication that is used along with diet and exercise to treat type 2 diabetes. Adlyxin belongs to a group of medications called glucagon-like peptide-1 (GLP-1) receptor agonists. It works by helping the pancreas to secrete insulin when blood sugar levels are high, decreases the amount of sugar the liver produces, and it slows the emptying of the stomach.

Adlyxin comes in an injectable form to be given just under the skin, once daily within one hour before the first meal of the day.

Common side effects include nausea, vomiting, diarrhea, and low blood sugar.

Adlyxin is an injectable prescription medicine that may improve blood sugar (glucose) control in adults with type 2 diabetes, when used with a diet and exercise program. 

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

Take Adlyxin exactly as prescribed by your healthcare provider. Follow the directions on your prescription label carefully.

Adlyxin should be initiated at 10 mcg once daily for 14 days. The 10 mcg dose is a starting dose intended to reduce gastrointestinal symptoms during initial titration, and is not effective for glycemic control. On Day 15, increase dosage to 20 mcg. 

Serious side effects may occur including:

Low blood sugar (hypoglycemia). Your risk for getting low blood sugar is higher if you take Adlyxin with another medicine that can cause low blood sugar, such as a sulfonylurea. The dose of your sulfonylurea medicine may need to be lowered while you use Adlyxin. Signs and symptoms of low blood sugar may include:

• headache
• drowsiness
• weakness
• dizziness
• confusion
• irritability
• hunger
• fast heart beat
• sweating
• feeling jittery

Talk with your healthcare provider about how to treat low blood sugar.

Kidney problems. Adlyxin may cause new or worse problems with kidney function, including kidney failure. Dialysis or kidney transplant may be needed. While taking Adlyxin: Call your healthcare provider right away if you have:

• nausea
• vomiting
• diarrhea that will not go away
• or if you cannot take liquids by mouth. You may be at increased risk for kidney problems.

Severe allergic reactions can happen with Adlyxin. Stop taking Adlyxin, and get medical help right away if you have any symptom of a severe allergic reaction. Do not use Adlyxin if you have had an allergic reaction to Adlyxin or any of the other ingredients in it.

Symptoms of a severe allergic reaction with Adlyxin may include:

• swelling of your face, lips, tongue, or throat
• problems breathing or swallowing
• severe rash or itching
• fainting or feeling dizzy
• very rapid heartbeat

Pancreatitis. Adlyxin may cause inflammation of the pancreas (pancreatitis), a potentially life-threatening condition. Tell your doctor right away if you have severe stomach pain and vomiting.

Serious side effects have been reported with Adlyxin. See "Drug Precautions" section.

The most common side effects with Adlyxin include:

• nausea. Nausea most commonly happens when first starting Adlyxin, but may become less over time.
• vomiting
• diarrhea or constipation
• dizziness
• headache
• feeling jittery
• acid stomach or indigestion
• low blood sugar

This is not a complete list of Adlyxin side effects. Ask your doctor or pharmacist for more information.

Tell your doctor about all the medicines you take including prescription and nonprescription medicines, vitamins, and herbal supplements. Adlyxin slows stomach emptying and can affect medicines that need to pass through the stomach quickly. Adlyxin may affect the way some medicines work and some other medicines may affect the way Adlyxin works.

Especially tell your doctor if you take:

• insulin, or any other anti-diabetes medicines
• birth control pills that are taken by mouth (oral contraceptives). Adlyxin may lower the amount of the medicine in your blood from your birth control pills and they may not work as well to prevent pregnancy. Take your birth control pills at least one hour before your injection of Adlyxin. If you must take your birth control pills with food, take it with a meal or snack where you do not also take Adlyxin.
• an antibiotic or acetaminophen, a pain reliever. Take these medicines at least one hour before taking Adlyxin. If you must take these medicines, take them with a meal or snack. You should not take these medicines at the same time you take Adlyxin.

This is not a complete list of Adlyxin drug interactions. Ask your doctor or pharmacist for more information.

Tell your doctor if you are pregnant or plan to become pregnant.

In animal studies, pregnant animals were given this medication and had some babies born with problems. No well-controlled studies have been done in humans, though. Therefore, this medication may be used if the potential benefits to the mother outweigh the potential risks to the unborn child.

It is not known if Adlyxin crosses into human milk.

Because many medications can cross into human milk and because of the possibility for serious adverse reactions in nursing infants with use of this medication, a choice should be made whether to stop nursing or stop the use of this medication. Your doctor and you will decide if the benefits outweigh the risk of using Adlyxin.