Zavesca

Zavesca is used to treat an enzyme deficiency known as type 1 Gaucher disease. It is only for people who cannot tolerate enzyme replacement therapy.

Zavesca Overview

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Zavesca is a prescription medication used to treat type 1 Gaucher's disease – a condition in which a certain fatty substance is not broken down normally in the body and instead builds up in some organs and causes liver, spleen, bone, and blood problems.

Zavesca belongs to a group of medications called enzyme inhibitors. It works by preventing the body from producing the fatty substance so that less of it will build up in the body and cause symptoms.

This medication comes in capsule form and is usually taken 3 times a day.

Do not chew, divide, or break Zavesca capsules. Swallow the capsules whole.

Common side effects of Zavesca include diarrhea, weight loss, stomach pain, gas, nausea and vomiting, headache including migraine, tremor, leg cramps, weakness, vision problems, thrombocytopenia, muscle cramps, back pain, constipation, dry mouth, heaviness in arms and legs, memory loss, unsteady walking, anorexia, indigestion, paresthesia, stomach bloating, stomach pain not related to food, and menstrual changes.

Zavesca can also cause dizziness. Do not drive or operate heavy machinery until you know how Zavesca affects you.

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Uses of Zavesca

Zavesca is a prescription medication used to treat type 1 Gaucher's disease – a condition in which a certain fatty substance is not broken down normally in the body and instead builds up in some organs and causes liver, spleen, bone, and blood problems.

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

Manufacturer

Zavesca Drug Class

Zavesca is part of the drug class:

Side Effects of Zavesca

Serious side effects have been reported with Zavesca. See the “Zavesca Precautions” section.

Common side effects of Zavesca include the following:

  • diarrhea
  • stomach pain or bloating
  • gas
  • loss of appetite
  • weight loss
  • upset stomach
  • vomiting
  • constipation
  • indigestion
  • dry mouth
  • weakness
  • muscle cramps, especially in the legs
  • feeling of heaviness in the arms or legs
  • unsteadiness when walking
  • back pain
  • dizziness
  • nervousness
  • headache
  • memory problems
  • difficult or irregular menstrual periods

This is not a complete list of Zavesca side effects. Ask your doctor or pharmacist for more information.

Tell your doctor if you have any side effect that bothers you or that does not go away.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Zavesca Interactions

Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you take imiglucerase (Cerezyme).

This is not a complete list of Zavesca drug interactions. Ask your doctor or pharmacist for more information.

Zavesca Precautions

Serious side effects have been reported with Zavesca including the following:

  • pain, burning, numbness or tingling in your hands, arms, legs, or feet
  • shaking hands that you cannot control
  • changes in vision
  • easy bruising or bleeding

Zavesca can cause dizziness. Do not drive or operate heavy machinery until you know how Zavesca affects you.

Do not take Zavesca if you are allergic to Zavesca or to any of its ingredients.

Zavesca Food Interactions

Medications can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of Zavesca, there are no specific foods that you must exclude from your diet when receiving this medication.

Inform MD

Before taking Zavesca, tell your doctor about all of your medical conditions. Especially tell your doctor if you:

  • are allergic to Zavesca or to any of its ingredients
  • have or have ever had a tremor (shaking of your hands that you cannot control
  • have or have had pain, burning, tingling, or numbness in your hands or feet
  • have or have had any disease that affects your nervous system
  • have or have had kidney disease
  • are pregnant or breastfeeding

Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements.

Zavesca and Pregnancy

Tell your doctor if you are pregnant or plan to become pregnant.

The FDA categorizes medications based on safety for use during pregnancy. Five categories - A, B, C, D, and X – are used to classify the possible risks to an unborn baby when a medication is taken during pregnancy.

Zavesca falls into category C. In animal studies, pregnant animals were given this medication and had some babies born with problems. No well-controlled studies have been done in humans. Therefore, this medication may be used if the potential benefits to the mother outweigh the potential risks to the unborn child.

Zavesca and Lactation

Tell your doctor if you are breastfeeding or plan to breastfeed.

It is not known if Zavesca crosses into human milk. Because many medications can cross into human milk and because of the possibility for serious adverse reactions in nursing infants with use of this medication, a choice should be made whether to stop nursing or stop the use of this medication. Your doctor and you will decide if the benefits outweigh the risk of using Zavesca.

Zavesca Usage

Take Zavesca exactly as prescribed.

This medication comes in capsule form and is usually taken 3 times a day.

Do not chew, divide, or break Zavesca capsules. Swallow the capsules whole.

Your doctor may prescribe another medicine (anti-diarrheal) to treat diarrhea if it is a problem for you and may recommend changes to your diet, such as avoiding foods high in carbohydrates while you are taking Zavesca. Talk with your doctor about your diet if you have diarrhea.

If you miss a dose, take the missed dose as soon as you remember. If it is almost time for the next dose, skip the missed dose and take your next dose at the regular time. Do not take two doses of Zavesca at the same time.

Zavesca Dosage

Take this medication exactly as prescribed by your doctor. Follow the directions on your prescription label carefully.

The dose your doctor recommends may be based on the following:

  • the condition being treated
  • other medical conditions you have
  • how you respond to this medication

The recommended dose of Zavesca is 100 mg three times daily. The dose may be reduced in patients who experience side effects or who have kidney problems.

Zavesca Overdose

If you take too much Zavesca, call your healthcare provider or local Poison Control Center, or seek emergency medical attention right away.

If Zavesca is administered by a healthcare provider in a medical setting, it is unlikely that an overdose will occur. However, if overdose is suspected, seek emergency medical attention.

Forms of Medication


Other Requirements

  • Store Zavesca at room temperature.
  • Protect from excess heat and moisture.
  • Keep this and all medicines out of the reach of children.