Sulfazine

Sulfazine Overview

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Sulfasalazine is a prescription medication used to treat the symptoms of ulcerative colitis including bowel inflammation, diarrhea (stool frequency), rectal bleeding, and abdominal pain. Sulfasalazine delayed-release (enteric-coated) is also used to treat rheumatoid arthritis in adults and children when other medications have not worked.

Sulfasalazine belongs to a group of drugs called aminosalicylates. It works by reducing inflammation (swelling) inside the body.

Sulfasalazine comes as regular and delayed-release tablets. It is usually taken four times daily after meals. Drink a full glass of water after taking sulfasalazine to protect the kidneys and to prevent kidney stones.

Common side effects include loss of appetite, nausea or vomiting, and headache.

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Sulfazine Cautionary Labels

precautionsprecautions

Uses of Sulfazine

Sulfasalazine is a prescription medication used:

  • in the treatment of mild to moderate ulcerative colitis, and as adjunctive therapy in severe ulcerative colitis; and
  • for the prolongation of the remission period between acute attacks of ulcerative colitis

​Sulfasalazine delayed-release is used to treat ulcerative colitis (as indicated above) as well as:

  • in the treatment of patients with rheumatoid arthritis who have responded inadequately to salicylates or other nonsteroidal anti-inflammatory drugs; and
  • in the treatment of pediatric patients with polyarticular-course1 juvenile rheumatoid arthritis who have responded inadequately to salicylates or other nonsteroidal anti-inflammatory drugs.

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

Sulfazine Drug Class

Sulfazine is part of the drug class:

Side Effects of Sulfazine

Serious side effects have been reported. See "Precautions".

Common side effects include:

  • diarrhea
  • headache
  • loss of appetite
  • upset stomach
  • vomiting
  • stomach pain

This is not a complete list of sulfasalazine side effects. Ask your doctor or pharmacist for more information.

Sulfazine Interactions

Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you take:

  • digoxin (Lanoxin)
  • folic acid

This is not a complete list of sulfasalazine drug interactions. Ask your doctor or pharmacist for more information.

Sulfazine Precautions

Do not take this medication if:

  • you are allergic to sulfasalazine, its metabolites, sulfonamides or salicylates
  • you have intestinal or urinary obstruction (blockage)
  • you have porphyria (enzyme problems)

This medication may make your skin more sensitive to sunlight. Avoid unnecessary or prolonged exposure to sunlight and to wear protective clothing, sunglasses, and sunscreen. 

Sulfazine Food Interactions

Medications can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of sulfasalazine, there are no specific foods that you must exclude from your diet when receiving this medication.

 

Inform MD

Before receiving sulfasalazine tell your doctor about all of your medical conditions including:

  • if you are allergic to sulfasalazine, sulfapyridine, aspirin, choline magnesium trisalicylate (Triosal, Trilisate), choline salicylate (Arthropan), mesalamine (Asacol, Pentasa, Rowasa), salsalate (Argesic-SA, Disalcid, Salgesic, others), sulfa drugs, trisalicylate (Tricosal, Trilisate),or any other drugs.
  • if you have or have ever had asthma, kidney or liver disease, porphyria, blood problems, or blockage in your intestine or urinary tract.
  • if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking sulfasalazine, call your doctor.

Tell your doctor about all of the medications you take including prescription and non-prescription medicines, vitamins, and herbal supplements.

Sulfazine and Pregnancy

Tell your doctor if you are pregnant or plan to become pregnant.

The FDA categorizes medications based on safety for use during pregnancy. Five categories - A, B, C, D, and X, are used to classify the possible risks to an unborn baby when a medication is taken during pregnancy.

Sulfasalazine falls into category B. There are no well-done studies that have been done in humans with sulfasalazine. In animal studies, pregnant animals were given this medication, and the babies did not show any medical issues related to this medication.

There have been case reports of neural tube defects (NTDs) in infants born to mothers who were exposed to sulfasalazine during pregnancy, but the role of sulfasalazine in these defects has not been established. However, oral sulfasalazine inhibits the absorption and metabolism of folic acid which may interfere with folic acid supplementation and diminish the effect of periconceptional folic acid supplementation that has been shown to decrease the risk of NTDs.

Sulfazine and Lactation

Tell your doctor if you are breastfeeding or plan to breastfeed.

Sulfasalazine has been detected in human breast milk. Because of the possibility for adverse reactions in nursing infants from sulfasalazine, a choice should be made whether to stop nursing or to stop use of this medication. The importance of the drug to the mother should be considered.

Sulfazine Usage

  • Sulfasalazine comes as regular and delayed-release (enteric-coated) tablets.
  • It usually is taken four times daily after meals in evenly spaced doses.
  • Take with a full glass of water.
  • Swallow delayed-release tablets whole; do not crush or chew them.
  • Drink plenty of fluids (at least six to eight glasses of water or other beverage per day) while taking sulfasalazine.

Sulfazine Overdose

If you take too much sulfasalazine call your local Poison Control center or seek emergency medical attention right away.

Other Requirements

  • Store at room temperature between 15–30° C (59–86° F).
  • Keep this and all medications out of the reach of children.