Pentasa

Pentasa treats an intestinal disease called ulcerative colitis. Stop taking this medication and call your doctor if you experience severe abdominal pain, bloody diarrhea, or develop a rash.

Pentasa Overview

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Pentasa is a prescription medication used to treat ulcerative colitis, or inflammation of the lining of the colon. It helps relieve the symptoms of ulcerative colitis including diarrhea, rectal bleeding, and stomach pain. Pentasa belongs to a group of drugs called aminosalicylates. These work by stopping the body from producing a certain substance that may cause pain or inflammation in the colon.

Pentasa is available as capsules and are usually taken taken up to 4 times a day, with or without food.

Common side effects of Pentasa include diarrhea, headache, and nausea.

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  • Colitis, Ulcerative
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Pentasa Cautionary Labels

precautions

Uses of Pentasa

Pentasa is a prescription medication used to treat ulcerative colitis (UC). UC is a condition in which part or all of the lining of the colon (also known as the large intestine) is swollen or worn away. It is used to cause the disease to temporarily go away ("induce remission").

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

 

 

Manufacturer

Pentasa Drug Class

Pentasa is part of the drug class:

Side Effects of Pentasa

Serious side effects have been reported with Pentasa. See “Pentasa Precautions” section.

Common side effects of Pentasa include:

  • headache
  • stomach pain
  • nausea
  • vomiting
  • diarrhea
  • rash

Other less common side effects include:

  • abnormal liver function tests
  • hair loss
  • itching
  • upset stomach
  • back pain
  • rash
  • joint pain
  • fatigue
  • high blood pressure

This is not a complete list of Pentasa side effects. Ask your doctor or pharmacist for more information.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Pentasa Interactions

Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you take:

  • medicines that can damage the kidneys, including non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Advil) and aspirin (Ecotrin)
  • azathioprine (Imuran)
  • 6-mercaptopurine (Purinethol)
  • antacids such as Maalox, Mylanta, Mag-Ox, Caltrate, Tums, or Rolaids

This is not a complete list of Pentasa drug interactions.  Ask your doctor or pharmacist for more information.

 

Pentasa Precautions

Serious side effects have been reported with Pentasa including:

  • Kidney problems. Tell your doctor if you take non-steroidal anti-inflammatory drugs or have kidney disease. Your doctor will check your kidney function with a simple blood test before you start taking Pentasa.
  • Pentasa may worsen ulcerative colitis. Tell your doctor if you experience the following symptoms:
    • cramping
    • acute abdominal pain
    • bloody diarrhea
    • fever
    • headache
    • rash
  • Hypersensitivity reaction. An allergic reaction is possible with Pentasa. Tell your doctor if you are allergic to sulfasalazine (Azulfidine) or Pentasa. Serious reactions can lead to heart problems, like myocarditis or pericarditis.
  • Liver failure is possible with Pentasa. Tell your doctor if you have liver disease.
  • Upper GI tract obstruction. Pyloric stenosis or an obstruction in the digestive tract could prevent Pentasa from reaching the colon and treating ulcerative colitis.
  • Pericarditis (inflammation of the lining around the heart). Tell your doctor if you experience symptoms of pericarditis including chest pain, rapid heartbeat, difficulty breathing, and fever. Your doctor may want to temporarily stop use of Pentasa.

Intact, partially intact, and/or capsule shells have been reported in the stool. Contact your doctor if this occurs repeatedly.

Do not take Pentasa if you:

  • have kidney disease
  • are allergic to mesalamine or any ingredients in Pentasa
  • are allergic to salicylates (including aspirin)

Pentasa Food Interactions

Medicines can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of Pentasa, there are no specific foods that you must exclude from your diet when receiving this medication.

 

Inform MD

Before taking Pentasa, tell your doctor about all your medical conditions. Especially tell your doctor if you:

  • have had an allergic reaction to sulfasalazine (Azulfidine), salicylates (such as aspirin), or Pentasa
  • are taking nonsteroidal anti-inflammatory drugs such as ibuprofen (Advil) and aspirin (Ecotrin) or other drugs that affect the kidneys
  • are taking azathioprine (Imuran) or 6-mercaptopurine (Purinethol)
  • have cramping, abdominal pain, bloody diarrhea, fevers, headaches, or rashes
  • have a history of myocarditis or pericarditis
  • have had inflamed pancreas (pancreatitis)
  • are allergic to other things, such as foods, preservatives, or dyes
  • have kidney, liver, or heart disease
  • have a history of stomach blockage
  • repeatedly see intact, partially intact, and/or capsule shells in the stool
  • are pregnant or breastfeeding

Tell your doctor about all the medicines you take including prescription and non-prescriptions medicines, vitamins, and herbal supplements.

Pentasa and Pregnancy

Tell your doctor if you are pregnant or plan to become pregnant.  

The FDA categorizes medications based on safety for use during pregnancy. Five categories – A, B, C, D, and X, are used to classify the possible risks to an unborn baby when a medication is taken during pregnancy.

Pentasa falls into category B. Studies in animals have failed to demonstrate a risk to the unborn baby and there are no well-controlled studies in pregnant women.

Pentasa and Lactation

Tell your doctor if you are breastfeeding or plan to breastfeed. The active ingredient in Pentasa is excreted in human breast milk. The effect of Pentasa on the nursing infant is not known.

 

Pentasa Usage

Take Pentasa exactly as prescribed. Do not change the dose or stop taking Pentasa without talking to your doctor.

Pentasa is available as capsules and are usually taken taken up to 4 times a day, with or without food.

 

Pentasa Dosage

Take this medication exactly as prescribed by your doctor. Follow the directions on your prescription label carefully.

  • Pentasa (mesalamine capsules)
    • The recommended dose for the induction of remission and the symptomatic treatment of mildly to moderately active ulcerative colitis is 1 gram (4 Pentasa 250 mg capsules or 2 Pentasa 500 mg capsules) 4 times a day for a total daily dosage of 4 grams.

 

Pentasa Overdose

If you take too much this medication, call your healthcare provider or local Poison Control Center, or seek emergency medical attention right away.

 

Other Requirements

  • Store Pentasa at at 25°C (77°F).
  • Keep this and all medicines out of the reach of children.