Prinzide

Prinzide treats high blood pressure. Avoid salt substitutes that contain potassium.

Prinzide Overview

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Prinzide is a prescription medication used to treat high blood pressure. It is a single product containing 2 medications: lisinopril and hydrochlorothiazide. Lisinopril belongs to a group of drugs called angiotensin-converting enzyme (ACE) inhibitors. Lisinopril works by blocking the ACE enzyme, which helps blood vessels to relax and lowers blood pressure. Hydrochlorothiazide belongs to a group of drugs called thiazide diuretics, which work by stopping reabsorption of salt into your body. This prevents fluid from building up in the body.

This medication comes in tablet form and is taken once daily, with or without food.

Common side effects include dizziness, headache, and cough. 

Prinzide can cause drowsiness and dizziness. Do not drive or operate heavy machinery until you know how Prinzide affects you. 

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Prinzide Cautionary Labels

precautionsprecautionsprecautionsprecautionsprecautions

Uses of Prinzide

Prinzide is a prescription medication used to treat high blood pressure.

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information. 

Manufacturer

Prinzide Drug Class

Prinzide is part of the drug class:

Side Effects of Prinzide

Serious side effects have been reported with Prinzide. See the "Prinzide Precautions" section. 

Common side effects of Prinzide include the following:

  • dizziness
  • headache
  • cough
  • tiredness/fatigue
  • low blood pressure upon standing (orthostatic hypotension)

This is not a complete list of Prinzide side effects. Ask your doctor or pharmacist for more information. 

Tell your doctor if you have any side effect that bothers you or that does not go away.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. 

Prinzide Interactions

Tell your doctor about all the medicines you take including prescription and nonprescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you are taking:

  • certain medications that also lower blood pressure such as angiotensin-­converting enzyme (ACE) inhibitors like enalapril (Vasotec, Vaseretic) and angiotensin receptor II blockers (ARBs) like valsartan (Diovan)
  • Diuretics like furosemide (Lasix), hydrochlorothiazide (Microzide, HCTZ), spironolactone (Aldactone), and triamterene (trade name Dyrenium)
  • nitroglycerin (Nitrostat)
  • digoxin (Lanoxin)
  • potassium supplements or potassium-containing salt substitutes
  • alcohol, a class of drugs called barbiturates, or a type of pain medications called narcotics
  • diabetic medications
  • cholestyramine (Questran) and colestipol (Colestid)
  • medicines that provide relief for inflamed areas of the body (corticosteroids) such as methylprednisolone (Medrol) and dexamethasone (Decadron)
  • substances that raise blood pressure (pressor amines) such as norepinephrine (Levophed)
  • medicines that relax skeletal muscles such as cyclobenzaprine (Flexeril) and carisoprodol (Soma)
  • lithium (Lithobid)
  • nonsteroidal anti-inflammatory drugs (NSAIDS) such as naproxen (Aleve) and ibuprofen (Advil)

This is not a complete list of Prinzide drug interactions. Ask your doctor or pharmacist for more information. 

Prinzide Precautions

Serious side effects have been reported with Prinzide or its ingredients including the following:

  • Narrowing of a heart valve and heart muscle thickening (aortic stenosis/hypertrophic cardiomyopathy)
  • Allergic reactions. Tell your healthcare provider right away if you have some or all of the following symptoms:
    • swelling of the face, limbs, lips, tongue, throat
    • difficulty breathing
    • stomach (abdominal) pain (intestinal angioedema) with or without nausea or vomiting
  • Low blood pressure. Tell your healthcare provider if you continue to experience light headedness. 
  • Liver damage.
  • Lowered white blood cell count (neutropenia) increasing the risk of infections
  • A condition in which close objects appear clearly, but far ones don't (myopia) or a buildup of pressure in the eye that can cause blindness (glaucoma). Tell your healthcare provider right away if you experience  visual changes or eye pain.
  • Harm to an unborn baby (fetal toxicity). Do not take Prinzide if you are pregnant or will become pregnant.
  • Imbalances in the levels of salts and fluids in your body (electrolyte and fluid imbalance). Tell your healthcare provider right away if you have some or all of the following symptoms:
    • dry mouth
    • thirst
    • weakness
    • drowsiness
    • restlessness
    • muscle pains or cramps
    • low blood pressure
    • low output of urine
    • fast heart rate
    • nausea
    • vomiting

Prinzide can cause drowsiness. Do not drive or operate heavy machinery until you know how Prinzide affects you.

Do not take Prinzide if you:

  • are allergic to Prinzide, lisinopril, to any other ACE inhibitor, to hydrochlorothiazide, or to other sulfonamide-derived drugs
  • kidneys are unable to produce urine (anuric)
  • history of a type of swelling that affects deeper layers in your skin, often around your eyes and lips (angioedema)

Prinzide Food Interactions

Medications can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of Prinzide, salt substitutes containing potassium should be avoided. 

Inform MD

Before taking Prinzide, tell your doctor about all of your medical conditions. Especially tell your doctor if:

  • you are allergic to Prinzide, lisinopril, to any other ACE inhibitor, to hydrochlorothiazide, or to other sulfonamide-derived drugs
  • your kidneys are unable to produce urine (anuric) or have kidney disease
  • you have a history of a type of swelling that affects deeper layers in your skin, often around your eyes and lips (angioedema)
  • you have diabetes
  • you are about to have major surgery
  • you are pregnant or plan to become pregnant
  • you are breastfeeding or plan to breastfeed

Tell you doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements. 

 

Prinzide and Pregnancy

Tell your doctor if you are pregnant or plan to become pregnant.

The FDA categorizes medications based on safety for use during pregnancy. Five categories - A, B, C, D, and X, are used to classify the possible risks to an unborn baby when a medication is taken during pregnancy.

Prinzide falls into category C in the first trimester and category D in the second and third trimester. When pregnancy is detected, discontinue Prinzide as soon as possible. Drugs that act directly on the renin-angiotensin system can cause injury and death to the unborn baby.

Prinzide and Lactation

Tell your doctor is you are breastfeeding or plan to breastfeed. 

It is not known if lisinopril, a component of Prinzide, is excreted in human breast milk. Hydrochlorothiazide, the other component of Prinzide, has been detected in human breast milk. Because of the possibility for adverse reactions in nursing infants from Prinzide, a choice should be made whether to stop nursing or to stop use of this medication. The importance of the drug to the mother should be considered. 

Prinzide Usage

  • Take Prinzide exactly as prescribed. 
  • Prinzide comes in a tablet form and is taken by mouth once daily with or without food. 

Prinzide Dosage

Take this medication exactly as prescribed by your doctor. Follow the directions on your prescription label carefully.

The dose your doctor recommends may be based on the following:

  • your blood pressure
  • previous medications used and the doses tried
  • how you respond to this medication
  • your other medical conditions

The usual recommended starting dose of Prinzide to treat high blood pressure is 10/12.5 mg once daily.The dose may be increased to one 20/12.5 mg tablet once daily, if needed. 

Prinzide Overdose

If you take too much Prinzide, call your healthcare provider or local Poison Control Center, or seek emergency medical attention right away. 

Other Requirements

  • Store at controlled room temperature, 59-86°F (15-30°C).
  • Protect from excessive light and humidity.
  • Dispense in a well-closed container. 
  • Keep this and all medications out of the reach of children. 

Prinzide FDA Warning

USE IN PREGNANCY: When used in pregnancy during the second and third trimesters, ACE inhibitors can cause injury and even death to the developing fetus. When pregnancy is detected, PRINZIDE should be discontinued as soon as possible. See WARNINGS, Pregnancy, Lisinopril, Fetal/Neonatal Morbidity and Mortality.