Lisinopril and Hydrochlorothiazide

Lisinopril and hydrochlorothiazide treats high blood pressure. Do not use during pregnancy.

Lisinopril and Hydrochlorothiazide Overview

Reviewed: July 27, 2015
Updated: 

Lisinopril and hydrochlorothiazide is a prescription medication used to treat high blood pressure. It is a single product containing 2 medications: lisinopril and hydrochlorothiazide. Lisinopril belongs to a group of drugs called angiotensin-converting enzyme (ACE) inhibitors. Lisinopril works by blocking the ACE enzyme, which helps blood vessels to relax and lowers blood pressure. Hydrochlorothiazide belongs to a group of drugs called thiazide diuretics, which work by stopping reabsorption of salt into your body. This prevents fluid from building up in the body.

This medication comes in tablet form and is typically given once daily with or without food.

Common side effects of lisinopril and hydrochlorothiazide include dizziness, headache, and cough. 

Lisinopril and hydrochlorothiazide can cause tiredness (fatigue) and dizziness. Do not drive or operate heavy machinery until you know how this medication affects you. 

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Lisinopril and Hydrochlorothiazide Cautionary Labels

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Uses of Lisinopril and Hydrochlorothiazide

Lisinopril and hydrochlorothiazide is a prescription medication used to treat high blood pressure.

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information. 

Lisinopril and Hydrochlorothiazide Brand Names

Lisinopril and Hydrochlorothiazide may be found in some form under the following brand names:

Lisinopril and Hydrochlorothiazide Drug Class

Lisinopril and Hydrochlorothiazide is part of the drug class:

Side Effects of Lisinopril and Hydrochlorothiazide

Serious side effects have been reported with lisinopril and hydrochlorothiazide. See the "Lisinopril and hydrochlorothiazide Precautions" section. 

Common side effects of lisinopril and hydrochlorothiazide include the following:

  • dizziness
  • headache
  • cough
  • tiredness/fatigue
  • low blood pressure upon standing (orthostatic hypotension)
  • diarrhea
  • nausea
  • infection that affects the nose, throat, and airways (upper respiratory infection)
  • muscle cramps
  • abnormal physical weakness or lack of energy (asthenia)
  • abnormal sensation of tingling or pricking (paresthesia)
  • low blood pressure (hypotension)
  • vomiting
  • indigestion 
  • rash
  • cannot get or keep an erection (impotence)

This is not a complete list of lisinopril and hydrochlorothiazide side effects. Ask your doctor or pharmacist for more information. 

Tell your doctor if you have any side effect that bothers you or that does not go away.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. 

Lisinopril and Hydrochlorothiazide Interactions

Tell your doctor about all the medicines you take including prescription and nonprescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you are taking:

  • certain medications that also lower blood pressure such as angiotensin-­converting enzyme (ACE) inhibitors like enalapril (Vasotec, Vaseretic) and angiotensin receptor II blockers (ARBs) like valsartan (Diovan)
  • Diuretics like furosemide (Lasix), hydrochlorothiazide (Microzide, HCTZ), spironolactone (Aldactone), and triamterene (trade name Dyrenium)
  • aliskiren (Tekturna)
  • potassium supplements or potassium-containing salt substitutes
  • alcohol, a class of drugs called barbiturates, or a type of pain medications called narcotics
  • diabetic medications
  • cholestyramine (Questran) and colestipol (Colestid)
  • medicines that provide relief for inflamed areas of the body (corticosteroids) such as methylprednisolone (Medrol) and dexamethasone (Decadron)
  • substances that raise blood pressure (pressor amines) such as norepinephrine (Levophed)
  • medicines that relax skeletal muscles such as cyclobenzaprine (Flexeril) and carisoprodol (Soma)
  • lithium (Lithobid)
  • nonsteroidal anti-inflammatory drugs (NSAIDS) such as naproxen (Aleve) and ibuprofen (Advil)
  • injectable gold (sodium aurothiomalate)

This is not a complete list of lisinopril and hydrochlorothiazide drug interactions. Ask your doctor or pharmacist for more information. 

Lisinopril and Hydrochlorothiazide Precautions

Serious side effects have been reported with lisinopril and hydrochlorothiazide or its ingredients including the following:

  • Narrowing of a heart valve and heart muscle thickening (aortic stenosis/hypertrophic cardiomyopathy)
  • Allergic reactions. Tell your healthcare provider right away if you have some or all of the following symptoms:
    • swelling of the face, limbs, lips, tongue, throat
    • difficulty breathing
    • stomach (abdominal) pain (intestinal angioedema) with or without nausea or vomiting
  • Low blood pressure. Tell your healthcare provider if you continue to experience light headedness. 
  • Liver damage.
  • Lowered white blood cell count (leukopenia/neutropenia/agranulocytosis) increasing the risk of infections
  • A condition in which close objects appear clearly, but far ones don't (myopia) or a buildup of pressure in the eye that can cause blindness (glaucoma). Tell your healthcare provider right away if you experience  visual changes or eye pain.
  • Harm to an unborn baby (fetal toxicity). Do not take lisinopril and hydrochlorothiazide if you are pregnant or will become pregnant.
  • Imbalances in the levels of salts and fluids in your body (electrolyte and fluid imbalance). Tell your healthcare provider right away if you have some or all of the following symptoms:
    • dry mouth
    • thirst
    • weakness
    • drowsiness
    • restlessness
    • muscle pains or cramps
    • low blood pressure
    • low output of urine
    • fast heart rate
    • nausea
    • vomiting

Lisinopril and hydrochlorothiazide can cause tiredness (fatigue) and dizziness. Do not drive or operate heavy machinery until you know how this medication affects you.

Do not take lisinopril and hydrochlorothiazide if you:

  • are allergic to lisinopril, to any other ACE inhibitor, to hydrochlorothiazide, or to other sulfonamide-derived drugs
  • kidneys are unable to produce urine (anuric)
  • have a history of a type of swelling that affects deeper layers in your skin, often around your eyes and lips (angioedema)
  • are a diabetic patient who is taking aliskiren (Tekturna)

Lisinopril and Hydrochlorothiazide Food Interactions

Medications can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of lisinopril and hydrochlorothiazide, salt substitutes containing potassium should be avoided. 

Inform MD

Before taking lisinopril and hydrochlorothiazide, tell your doctor about all of your medical conditions. Especially tell your doctor if:

  • are allergic to lisinopril, to any other ACE inhibitor, to hydrochlorothiazide, or to other sulfonamide-derived drugs
  • kidneys are unable to produce urine (anuric) or have kidney disease
  • have a history of a type of swelling that affects deeper layers in your skin, often around your eyes and lips (angioedema)
  • are a diabetic, especially if you are taking aliskiren (Tekturna)
  • you are about to have major surgery
  • you are breastfeeding or plan to breastfeed
  • you are pregnant or plan to become pregnant

Tell you doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements. 

Lisinopril and Hydrochlorothiazide and Pregnancy

Tell your doctor if you are pregnant or plan to become pregnant.

The FDA categorizes medications based on safety for use during pregnancy. Five categories - A, B, C, D, and X, are used to classify the possible risks to an unborn baby when a medication is taken during pregnancy.

Lisinopril and hydrochlorothiazide falls into category D. When pregnancy is detected, discontinue lisinopril and hydrochlorothiazide as soon as possible. Drugs that act directly on the renin-angiotensin system can cause injury and death to the unborn baby.

Lisinopril and Hydrochlorothiazide and Lactation

Tell your doctor is you are breastfeeding or plan to breastfeed. 

It is not known if lisinopril is excreted in human breast milk. Hydrochlorothiazide has been detected in human breast milk. Because of the possibility for adverse reactions in nursing infants from lisinopril and hydrochlorothiazide, a choice should be made whether to stop nursing or to stop use of this medication. The importance of the drug to the mother should be considered. 

Lisinopril and Hydrochlorothiazide Usage

  • Take lisinopril and hydrochlorothiazide exactly as prescribed. 
  • Lisinopril and hydrochlorothiazide comes in a tablet form and is taken by mouth once daily with or without food. 
  • If you miss a dose, take the missed dose as soon as you remember. If it is almost time for the next dose, skip the missed dose and take your next dose at the regular time. Do not take two doses of lisinopril and hydrochlorothiazide at the same time. 

Lisinopril and Hydrochlorothiazide Dosage

Take this medication exactly as prescribed by your doctor. Follow the directions on your prescription label carefully.

The dose your doctor recommends may be based on the following:

  • your blood pressure
  • previous medications used and the doses tried
  • how you respond to this medication
  • your other medical conditions
  • other medications you are taking

The recommended dosing of lisinopril and hydrochlorothiazide for treating high blood pressure is based on its two components: lisinopril and hydrochlorothiazide. Lisinopril's recommended dose range is 10 mg to 80 mg once daily. Hydrochlorothiazide's recommended dose range is 12.5 mg to 50 mg once daily.

Lisinopril and Hydrochlorothiazide Overdose

If you take too much lisinopril and hydrochlorothiazide, call your healthcare provider or local Poison Control Center, or seek emergency medical attention right away. 

Other Requirements

  • Store at room temperature, 68-77°F (20-25°C).
  • Protect from excessive light and humidity.
  • Keep this and all medications out of the reach of children. 

Lisinopril and Hydrochlorothiazide FDA Warning

WARNING: FETAL TOXICITY

  • When pregnancy is detected, discontinue lisinopril and hydrochlorothiazide as soon as possible.
  • Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus. See Warnings: Fetal Toxicity.