Nardil

Nardil treats depression. This medication interacts with tyramine which is found in some cheeses and other foods which can result in dangerously high blood pressure. Avoid these foods and drinks.

Nardil Overview

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Nardil is a prescription medication used to treat depression. Because of its potentially serious side effects, it is often used only after other antidepressants haven't worked. Nardil belongs to a group of drugs called monoamine oxidase (MAO) inhibitors. It works by increasing the levels of certain natural chemicals in the brain that affect your mood and help maintain mental balance.

Nardil comes in tablet form. It is usually taken 3 times daily, with or without food.

Common side effects include dizziness, headache, and insomnia. Nardil can cause drowsiness. Do not drive or operate heavy machinery until you know how it affects you.

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Nardil Cautionary Labels

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Uses of Nardil

Nardil is a prescription medication used to treat depression, when other medications have failed.

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

Manufacturer

Nardil Drug Class

Nardil is part of the drug class:

Side Effects of Nardil

Serious side effects have been reported. See "Drug Precautions" section.

Common side effects include:

  • dry mouth
  • dizziness
  • headaches
  • weight gain
  • nausea
  • constipation
  • decreased sexual ability
  • insomnia
  • drowsiness
  • weakness
  • low blood pressure when standing or sitting up
  • muscle twitches or shakiness

This is not a complete list of Nardil side effects. Ask your doctor or pharmacist for more information.

Nardil Interactions

Tell your doctor about all of the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you take:

  • certain other antidepressants including amitriptyline (Elavil), amoxapine, clomipramine (Anafranil), desipramine (Norpramin), doxepin (Sinequan), imipramine (Tofranil), maprotiline, mirtazapine (Remeron), nortriptyline (Pamelor), protriptyline (Vivactil), and trimipramine (Surmontil)
  • amphetamines such as amphetamine (in Adderall), benzphetamine (Didrex), dextroamphetamine (Dexedrine, Dextrostat, in Adderall), and methamphetamine (Desoxyn)
  • barbiturates such as pentobarbital (Nembutal), phenobarbital (Luminal), and secobarbital (Seconal)
  • beta blockers such as atenolol (Tenormin), labetalol (Normodyne), metoprolol (Lopressor, Toprol XL), nadolol (Corgard), and propranolol (Inderal)
  • bupropion (Wellbutrin, Zyban)
  • buspirone (BuSpar)
  • caffeine (No-Doz, Quick-Pep, Vivarin)
  • cyclobenzaprine (Flexeril)
  • dexfenfluramine (Redux) (not available in the U.S.)
  • dextromethorphan (Robitussin, others)
  • doxepin cream (Zonelon)
  • duloxetine (Cymbalta)
  • epinephrine (Epipen, Primatene Mist)
  • guanethidine (Ismelin) (not available in the U.S.)
  • insulin and oral medications for diabetes
  • levodopa (Larodopa, in Sinemet)
  • medications for allergies, cough and cold symptoms, hay fever; anxiety, sinus problems, or weight loss (diet pills, appetite suppressants)
  • medication for high blood pressure including diuretics ('water pills'), and reserpine (Serpalan)
  • medications for seizures such as carbamazepine (Tegretol)
  • narcotic medications for pain
  • nasal decongestants, including nose drops and sprays
  • other MAOIs such as isocarboxazid (Marplan), pargyline (not available in the U.S.), procarbazine (Matulane), tranylcypromine (Parnate), and selegiline (Eldepryl, Emsam, Zelapar)
  • meperidine (Demerol)
  • methyldopa (Aldomet)
  • sedatives
  • selective serotonin reuptake inhibitors such as citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac), fluvoxamine (Luvox), paroxetine (Paxil), and sertraline (Zoloft)
  • sleeping pills
  • tranquilizers
  • venlafaxine (Effexor)
  • medications containing alcohol (Nyquil, elixirs, others)

This is not a complete list of Nardil drug interactions. Ask your doctor or pharmacist for more information.

Nardil can remain in your body for several weeks after you stop taking it. Tell your doctor or pharmacist that you recently stopped taking Nardil before you start taking any new medications.

 

Nardil Precautions

Serious side effects have been reported with Nardil including:

  • hypertensive crisis, a life threatening increase in blood pressure. This sometimes fatal side effect can result from taking MAO inhibitors like Nardil with certain drugs and foods (see "Drug Interactions" and "Food Interactions" sections). Symptoms include:
    • headaches
    • stiff or sore neck
    • nausea
    • vomiting
    • palpitations
    • sweating, sometimes with fever and cold, clammy skin
    • either fast or slow heart beat
    • chest pain
    • chest tightness
    • dilated pupils

Get medical help right away if you experience these symptoms.

  • severe headaches. If you have frequent headaches, talk to your doctor before starting Nardil as headaches are one of the first symptoms of a hypertensive crisis and you may miss this warning sign.
  • suicidal thoughts or behavior. Antidepressants may increase suicidal thoughts or actions in some children, teenagers, and young adults within the first few months of treatment.
    • Pay close attention to any changes, especially sudden changes, in mood, behaviors, thoughts, or feelings. This is very important when an antidepressant medicine is started or when the dose is changed.
    • Call the healthcare provider right away to report new or sudden changes in mood, behavior, thoughts, or feelings.
  • low blood pressure, especially when getting up from a lying position.

Nardil can cause drowsiness. Do not drive or operate heavy machinery until you know how it affects you.

Do not take Nardil if you:

  • are allergic to any ingredient in Nardil 
  • have a type of adrenal tumor known as pheochromocytoma
  • have congestive heart failure
  • have severe kidney disease
  • have a history of liver disease
  • a type of adrenal tumor known as pheochromocytoma

Nardil Food Interactions

Tyramine is a naturally occurring compound found in some cheeses and other foods that may cause dangerously high blood pressure in people taking monoamine oxidase inhibitors (MAOIs) like Nardil.

You should avoid eating very large amounts of foods containing high amounts of tyramine such as:

  • cheese (particularly strong or aged varieties)
  • sour cream
  • Chianti wine
  • sherry
  • beer (including non-alcoholic beer)
  • liqueurs
  • pickled herring
  • anchovies
  • caviar
  • liver
  • canned figs
  • raisins
  • bananas
  • avocados (particularly if overripe)
  • chocolate
  • soy sauce
  • sauerkraut
  • the pods of broad beans (fava beans)
  • yeast extracts
  • yogurt
  • meat extracts
  • meat prepared with tenderizers
  • dry sausage

Some of the signs and symptoms of dangerously high blood pressure (hypertensive crisis) are:

  • severe headache
  • vision problems
  • confusion
  • stupor (mental numbness)
  • coma
  • seizures
  • chest pain
  • unexplained nausea or vomiting
  • stroke-like symptoms (sudden numbness or weakness - especially on one side of the body)

Get emergency medical help if you experience these symptoms.

Inform MD

Before taking Nardil tell your doctor about all of your medical conditions. Especially tell your doctor if you:

  • are allergic to any ingredient in Nardil 
  • have pheochromocytoma
  • have congestive heart failure
  • have severe kidney disease
  • have a history of liver disease
  • are pregnant or breastfeeding

Tell your doctor about all of the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements.

Nardil and Pregnancy

Tell your doctor if you are pregnant or plan to become pregnant. It is not known if Nardil will harm your unborn baby.

 

Nardil and Lactation

Tell your doctor if you are breastfeeding or plan to breastfeed. It is not known if Nardil is excreted in human breast milk or if it will harm your nursing baby.

Nardil Usage

  • Take Nardil exactly as prescribed.
  • Nardil comes in tablet form and is usually taken 3 times a day.
  • It can be taken with or without food.
  • If Nardil upsets your stomach, try taking it with food.
  • If you miss a dose, take the missed dose as soon as you remember. If it is almost time for the next dose, skip the missed dose and take your next dose at the regular time. Do not take two doses of Nardil at the same time.

Nardil Dosage

Take Nardil exactly as prescribed by your doctor. Follow the directions on your prescription label carefully.

The Nardil dose your doctor recommends will be based on the following:

  • other medical conditions you have
  • other medications you are taking
  • how you respond to this medication 

The usual starting dose of Nardil is one tablet (15 mg) three times a day.

Dosage should be increased to at least 60 mg per day. After maximum benefit from Nardil is achieved, dosage should be reduced slowly over several weeks. Maintenance dose may be as low as one tablet, 15 mg, a day or every other day, and should be continued for as long as is required.

 

Nardil Overdose

If you take too much Nardil, call your local Poison Control Center or seek emergency medical attention right away.

Other Requirements

  • Store at room temperature between 15°C and 30°C (59 - 86°F).
  • Keep this and all medications out of the reach of children.

Nardil FDA Warning

Suicidality and Antidepressant Drugs

Antidepressants increased the risk compared to placebo of suicidal thinking and behavior (suicidality) in children, adolescents, and young adults in short-term studies of major depressive disorder (MDD) and other psychiatric disorders. Anyone considering the use of Nardil or any other antidepressant in a child, adolescent, or young adult must balance this risk with the clinical need. Short-term studies did not show an increase in the risk of suicidality with antidepressants compared to placebo in adults beyond age 24; there was a reduction in risk with antidepressants compared to placebo in adults aged 65 and older. Depression and certain other psychiatric disorders are themselves associated with increases in the risk of suicide. Patients of all ages who are started on antidepressant therapy should be monitored appropriately and observed closely for clinical worsening, suicidality, or unusual changes in behavior. Families and caregivers should be advised of the need for close observation and communication with the prescriber. Nardil is not approved for use in pediatric patients.