Oxymorphone treats moderate to severe pain. Do not drink alcohol while taking this medication.

Oxymorphone Overview

Reviewed: November 20, 2014

Oxymorphone is a prescription medication used to treat moderate to severe pain. 

Oxymorphone belongs to a group of drugs called called opiate (narcotic) analgesics. These work by changing the way the body responds to pain.

Oxymorphone is available in a tablet form and is usually given every four to six hours. It will depend on how intense your pain is. 

This medication comes as an extended release tablet and is taken typically 2 times a day.

Do not crush, chew, or break oxymorphone extended release tablets. Swallow the extended release tablets whole. 

Oxymorphone tablets should be taken on an empty stomach, at least 1 hour before or 2 hours after meals. 

This medication is also available in an injectable form to be given directly into a vein (IV), in the muscle (IM), and under your skin (subcutaneously) by a healthcare professional.

Common side effects include constipation, nausea, and vomiting.

Oxymorphone can also cause drowsiness and dizziness. Do not drive or operate heavy machinery until you know how oxymorphone affects you.

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Oxymorphone Cautionary Labels


Uses of Oxymorphone

Oxymorphone is a prescription medication used to relieve moderate to severe pain for those who need pain medication around the clock.


This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

Oxymorphone Brand Names

Oxymorphone may be found in some form under the following brand names:

Oxymorphone Drug Class

Oxymorphone is part of the drug class:

Side Effects of Oxymorphone

Serious side effects have been reported with oxymorphone. See the “Oxymorphone Precautions” section.

Common side effects of oxymorphone tablets include the following:

  • constipation
  • nausea
  • vomiting
  • tiredness
  • headache
  • stomach pain
  • drowsiness
  • dizziness
  • increased sweating
  • dry mouth
  • diarrhea
  • insomnia  (difficulty falling asleep or staying asleep)
  • fatigue (tired)
  • decreased appetite
  • itching

Common side effects of oxymorphone injection include the following:

  • blurred vision
  • fast heart rate
  • nausea
  • vomiting
  • constipation
  • fatigue (tired)
  • euphoric mood (feeling high)
  • rash
  • low blood pressure
  • flushing
  • itching

This is not a complete list of oxymorphone side effects. Ask your doctor or pharmacist for more information.

Tell your doctor if you have any side effect that bothers you or that does not go away.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.