Opana ER

Opana ER treats moderate to severe pain. Do not drink alcohol while taking this medication.

Opana ER Overview


Opana ER is a prescription medication used to treat moderate to severe pain. Opana ER belongs to a group of drugs called called opiate (narcotic) analgesics. These work by changing the way the body responds to pain.

This medication comes in an extended release tablet form and is taken every 12 hours (twice daily). It is taken on an empty stomach, at least 1 hour before or 2 hours after meals. 

Do not crush, chew, or break tablets. Swallow Opana ER tablets whole. 

Common side effects include constipation, nausea, and headache.

Opana ER can also cause drowsiness and dizziness. Do not drive or operate heavy machinery until you know how it affects you.

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Opana ER Cautionary Labels


Uses of Opana ER

Opana ER is a prescription medication used to relieve moderate to severe pain for those who need pain medication around the clock. Opana ER is NOT intended to be used as an "as needed" pain reliever.

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.



For more information on this medication choose from the list of selections below.

Opana ER Drug Class

Opana ER is part of the drug class:

Side Effects of Opana ER

Serious side effects have been reported with Opana ER. See the “Opana ER Precautions” section.

Common side effects of Opana ER include the following:

  • constipation
  • drowsiness
  • nausea
  • vomiting
  • tiredness
  • headache
  • stomach pain
  • dizziness
  • increased sweating
  • dry mouth
  • diarrhea
  • insomnia  (difficulty falling asleep or staying asleep)
  • fatigue (tired)
  • decreased appetite
  • itching

This is not a complete list of Opana ER side effects. Ask your doctor or pharmacist for more information.

Tell your doctor if you have any side effect that bothers you or that does not go away.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Opana ER FDA Warning


OPANA ER contains oxymorphone, which is a morphine-like opioid agonist and a Schedule II controlled substance, with an abuse liability similar to other opioid analgesics.

Oxymorphone can be abused in a manner similar to other opioid agonists, legal or illicit. This should be considered when prescribing or dispensing OPANA ER in situations where the physician or pharmacist is concerned about an increased risk of misuse, abuse, or diversion.

OPANA ER is an extended-release oral formulation of oxymorphone indicated for the management of moderate to severe pain when a continuous, around-the-clock opioid analgesic is needed for an extended period of time.

OPANA ER is NOT intended for use as a prn analgesic.

OPANA ER Tablets are to be swallowed whole and are not to be broken, chewed, dissolved, or crushed. Taking broken, chewed, dissolved, or crushed OPANA ER Tablets leads to rapid release and absorption of a potentially fatal dose of oxymorphone.

Patients must not consume alcoholic beverages, or prescription or non-prescription medications containing alcohol, while on OPANA ER therapy. The co-ingestion of alcohol with OPANA ER may result in increased plasma levels and a potentially fatal overdose of oxymorphone.