Adrenaline Rush ... or Tumor?

Scientists identify 12 new potential variations of genetic mutations linked to adrenal-gland tumors

/ Author:  / Reviewed by: Joseph V. Madia, MD

(RxWiki News) Scientists have identified 13 new potential variations of genetic mutations associated with adrenal-gland tumors, known as pheochromocytomas.

Pheochromocytomas can affect the adrenal gland located above the kidney, resulting in symptoms that include high blood pressure, headaches, heart palpitations, nausea and vomiting from too much adrenaline released in the system. The tumors are usually benign but can be cancerous.

Scientists discovered a total of 19 mutations in the FP/TMEM127 gene in 20 patients (out of 1,000 enlisted in the study), which may be associated with pheochromocytomas in the adrenal gland. Of these, 13 mutations were new discoveries, while the remainder had been previously reported.

"These observations support the existence of additional pheochromocytoma susceptibility genes, which may account for some of the genetically undefined cases," the authors wrote.

Reviewed by: 
Review Date: 
December 20, 2010
Last Updated:
January 17, 2011