Sutent

Sutent treats certain types of cancer. The medicine in Sutent is yellow, and it may make your skin look yellow. Your skin and hair may get lighter in color.

Sutent Overview

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Sutent is a prescription medication used to treat a certain type of gastrointestinal cancer as well as cancer of the kidney and pancreas. Sutent belongs to a group of drugs called kinase inhibitors, which work by blocking the action of the abnormal protein that signals cancer cells to multiply.

This medication comes in capsule form and is taken once daily, with or without food. It is taken for 4 weeks followed by a 2 week break before starting another dosing cycle.

Common side effects of Sutent include skin yellowing, tiredness, weakness and fever.

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Sutent Cautionary Labels

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Uses of Sutent

Sutent is a prescription medication used to treat a certain gastrointestinal cancer as well as cancer of the kidney and pancreas. Specifically, Sutent is used to treat people with:

  • a rare cancer of the stomach, bowel, or esophagus called GIST (gastrointestinal stromal tumor) and when the medicine Gleevec (imatinib mesylate) did not stop the cancer from growing, or you cannot take Gleevec. 
  • advanced kidney cancer (advanced renal cell carcinoma or RCC) 
  • a type of pancreatic cancer known as pancreatic neuroendocrine tumors (pNET), that has progressed and cannot be treated with surgery.

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

Manufacturer

Sutent Drug Class

Sutent is part of the drug class:

Side Effects of Sutent

Sutent may cause serious side effects. See the "Sutent Precautions" section.

Common side effects of Sutent include:

  • tiredness 
  • weakness 
  • fever 
  • gastrointestinal symptoms, including diarrhea, nausea, vomiting, mouth sores, upset stomach, abdominal pain, and constipation. Talk with your healthcare provider about ways to handle these problems. 
  • rash or other skin changes, including drier, thicker, or cracking skin. 
  • blisters or a rash on the palms of your hands and soles of your feet. 
  • taste changes 
  • loss of appetite 
  • pain or swelling in your arms or legs 
  • cough 
  • shortness of breath 
  • bleeding, such as nosebleeds or bleeding from cuts. 

The medicine in Sutent is yellow, and it may make your skin look yellow. Your skin and hair may get lighter in color.

Call your healthcare provider if you have any swelling or bleeding during treatment with Sutent. These are not all the possible side effects of Sutent. For more information, ask your healthcare provider or pharmacist.    

Sutent Interactions

Tell your doctor about the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you take:

  • ketoconazole
  • itraconazole
  • clarithromycin
  • atazanavir
  • indinavir
  • nefazodone
  • nelfinavir
  • ritonavir
  • saquinavir
  • telithromycin
  • voriconazole
  • dexamethasone
  • phenytoin
  • carbamazepine
  • rifampin
  • rifabutin
  • rifapentin
  • phenobarbital
  • St. John's Wort

These are not all the possible drug interactions with Sutent. For more information, ask your healthcare provider.

Sutent Precautions

Serious side effects have been reported with Sutent including the following:

  • Liver problems, including death (see Black Box Warning). Tell your healthcare provider right away if you develop any of the following signs and symptoms of liver problems during treatment with Sutent:
    • itching
    • yellow eyes or skin,
    • dark urine, and
    • pain or discomfort in the right upper stomach area.
      • Your healthcare provider should do blood tests to check your liver function before you start taking Sutent and during treatment.
  • Heart problems. Heart problems may include heart failure and heart muscle problems (cardiomyopathy) that can lead to death. Tell your healthcare provider if you feel very tired, are short of breath, or have swollen feet and ankles. 
  • Abnormal heart rhythm changes. Your healthcare provider may do electrocardiograms and blood tests to watch for these problems during your treatment with Sutent. Tell your healthcare provider if you feel dizzy, faint, or have abnormal heartbeats while taking Sutent. 
  • High blood pressure. Your healthcare provider may check your blood pressure during treatment with Sutent. Your healthcare provider may prescribe medicine for you to treat high blood pressure, if needed.
  • Bleeding sometimes leading to death. Tell your healthcare provider right away if you have any of these symptoms or a serious bleeding problem during treatment with Sutent.
    • painful, swollen stomach (abdomen) 
    • vomiting blood 
    • black, sticky stools 
    • bloody urine 
    • headache or change in your mental status
  • Hormone problems, including thyroid and adrenal gland problems. Your healthcare provider may do tests to check your thyroid and adrenal gland function during Sutent treatment. Tell your doctor if you have any of the following signs and symptoms during treatment with Sutent:
    • tiredness that worsens and does not go away 
    • loss of appetite 
    • heat intolerance 
    • feeling nervous or agitated, tremors 
    • sweating 
    • nausea or vomiting 
    • diarrhea 
    • fast heart rate 
    • weight gain or weight loss 
    • feeling depressed 
    • irregular menstrual periods or no menstrual periods 
    • headache 
    • hair loss

Do not take Sutent if you are allergic to any of its ingredients.

Sutent Food Interactions

Grapefruit and grapefruit juice may interact with Sutent and lead to potentially dangerous effects. Discuss the use of grapefruit products with your doctor.

Inform MD

Before taking Sutent tell your healthcare provider if you:

  • have any heart problems 
  • have high blood pressure 
  • have thyroid problems 
  • plan to have surgery 
  • have kidney function problems (other than cancer) 
  • have liver problems 
  • have any bleeding problem 
  • have seizures 
  • have any other medical conditions 
  • if you are having surgery (including dental surgery)
  • are pregnant, could be pregnant or plan to become pregnant. Sutent may harm an unborn baby. You should not become pregnant while taking Sutent. Tell your healthcare provider right away if you become pregnant while taking Sutent. 
  • are breastfeeding or plan to breastfeed. You and your healthcare provider should decide if you will take Sutent or breastfeed. You should not do both.


Tell your healthcare provider about all the medicines you take, including prescription medicines and non-prescription medicines, vitamins, and herbal supplements. Using Sutent with certain other medicines can cause serious side effects. Know the medicines you take. Keep a list of them to show your healthcare provider and pharmacist when you get a new medicine. Talk with your healthcare provider before starting any new medicines.

Sutent and Pregnancy

Tell your healthcare provider if you are pregnant, could be pregnant or plan to become pregnant. Sutent may harm an unborn baby. You should not become pregnant while taking Sutent. Tell your healthcare provider right away if you become pregnant while taking Sutent. 

Sutent and Lactation

Tell your healthcare provider if you are breastfeeding or plan to breastfeed. You and your healthcare provider should decide if you will take Sutent or breastfeed. You should not do both.

Sutent Usage

  • Take Sutent exactly the way your healthcare provider tells you. 
  • Take Sutent 1 time each day with or without food. 
  • If you take Sutent for GIST or RCC, you will usually take your medicine for 4 weeks (28 days) and then stop for 2 weeks (14 days). This is 1 cycle of treatment. You will repeat this cycle for as long as your healthcare provider tells you to. 
  • If you take Sutent for pNET, take it one time each day until your healthcare provider tells you to stop. 
  • Do not open the Sutent capsules. 
  • Do not drink grapefruit juice or eat grapefruit during your treatment with Sutent. They may cause you to have too much Sutent in your body. 
  • Your healthcare provider may do blood tests before each cycle of treatment. 
  • If you miss a dose, take it as soon as you remember. Do not take it if it is close to your next dose. Just take the next dose at your regular time. Do not take more than 1 dose of Sutent at a time. Tell your healthcare provider about any missed dose. 
  • Call your healthcare provider right away, if you take too much Sutent.

Sutent Dosage

Take Sutent exactly as prescribed by your doctor. Follow the directions on your prescription label carefully. Your doctor will determine the best dose for you.

The recommended dose of Sutent for gastrointestinal stromal tumor (GIST) and advanced renal cell carcinoma (RCC) is one 50 mg oral dose taken once daily, on a schedule of 4 weeks on treatment followed by 2 weeks off (Schedule 4/2). Sutent may be taken with or without food.

The recommended dose of Sutent for pancreatic neuroendocrine tumors (pNET) is 37.5 mg taken orally once daily continuously without a scheduled off-treatment period. Sutent may be taken with or without food.

 

Sutent Overdose

If you take too much this medication, call your healthcare provider or local Poison Control Center, or seek emergency medical attention right away.

If this medication is administered by a healthcare provider in a medical setting, it is unlikely that an overdose will occur. However, if overdose is suspected, seek emergency medical attention.

Other Requirements

  • Store Sutent at room temperature, between 59°F and 86°F (15°C to 30°C).
  • Keep this and all medicines out of the reach of children.
 

Sutent FDA Warning

WARNING: HEPATOTOXICITY

Hepatotoxicity has been observed in clinical trials and post-marketing experience. This hepatotoxicity may be severe, and deaths have been reported.