Levomilnacipran

Levomilnacipran treats depression. It may take several weeks before you see the full benefit of this medication.

Levomilnacipran Overview

Reviewed: May 5, 2014
Updated: 

Levomilnacipran is a prescription medication used to treat depression. Levomilnacipran belongs to a group of drugs called serotonin norepinephrine reuptake inhibitors (SNRIs), which work by increasing serotonin and norepinephrine levels in the brain to maintain mental balance and improve mood.

This medication comes in capsule form and is taken once a day, with or without food.

Do not open, chew, or crush levomilnacipran capsules. Swallow capsules whole.

Common side effects of levomilnacipran include nausea or vomiting, constipation, sweating, increased heart rate, erectile dysfunction, and palpitations.

Levomilnacipran can also cause blurred vision and/or dizziness. Do not drive or operate heavy machinery until you know how levomilnacipran affects you.

 

 

 

Patient Ratings for

How was your experience with ?

First, a little about yourself

Tell us about yourself in a few words?

What tips would you provide a friend before taking ?

What are you taking for?

Choose one
  • Other

How long have you been taking it?

Choose one
  • Less than a week
  • A couple weeks
  • A month or so
  • A few months
  • A year or so
  • Two years or more

How well did work for you?

Did you experience many side effects while taking this drug?

How likely would you be to recommend to a friend?

Levomilnacipran Cautionary Labels

precautionsprecautionsprecautionsprecautionsprecautions

Uses of Levomilnacipran

Levomilnacipran is a prescription medication used to treat depression.

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

 

Levomilnacipran Brand Names

Levomilnacipran may be found in some form under the following brand names:

Levomilnacipran Drug Class

Levomilnacipran is part of the drug class:

Side Effects of Levomilnacipran

Serious side effects have been reported with levomilnacipran. See the “Levomilnacipran Precautions” section.

Common side effects of levomilnacipran include the following:

  • nausea or vomiting
  • constipation
  • sweating
  • increased heart rate
  • erectile dysfunction
  • palpitations

This is not a complete list of levomilnacipran side effects. Ask your doctor or pharmacist for more information.

Tell your doctor if you have any side effect that bothers you or that does not go away.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

 

Levomilnacipran Interactions

Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you take:

  • Triptans such as sumatriptan (Imitrex, Treximet), eletriptan (Relpax), almotriptan (Axert), frovatriptan (Frova), naratriptan (Amerge), rizatriptan (Maxalt), and zolmitriptan (Zomig)
  • Medications that could lead to serotonin syndrome such as citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem), fluvoxamine (Luvox), desvenlafaxine (Pristiq), nefazodone (Serzone), paroxetine (Paxil, Pexeva), sertraline (Zoloft), venlafaxine (Effexor), trimipramine (Surmontil), amitriptyline (Elavil), nortriptyline (Pamelor, Aventyl), protriptyline (Vivactil), and clomipramine (Anafranil), and linezolid (Zyvox)
  • Monoamine oxidase inhibitors such as isocarboxazid (Marplan), phenelzine (Nardil), tranylcypromine (Parnate), selegiline (Emsam, Eldepryl, Zelapar), rasagiline (Azilect)
  • tramadol (Ultram)
  • fentanyl (Duragesic)
  • Tryptophan 
  • St. John's Wort
  • Aspirin and other NSAIDs (nonsteroidal anti-inflammatory drugs) such as celecoxib (Celebrex), diclofenac (Cambia, Cataflam, Flector, Voltaren, Zipsor and others), etodolac (Lodine), ibuprofen (Advil, Motrin, Nuprin), indomethacin (Indocin, Indocin SR), ketoprofen (Orudis, Actron, Oruvail), ketorolac (Toradol), meloxicam (Mobic), nabumetone (Relafen), naproxen (Naprosyn), naproxen sodium (Aleve, Anaprox, Naprelan), oxaprozin (Daypro), piroxicam (Feldene)
  • Blood thinners such as warfarin (Coumadin, Jantoven)
  • Diuretics (water pills) such as acetazolamide (Diamox), amiloride (Midamor), bumetanide (Bumex), chlorothiazide (Diuril), chlorthalidone (Thalitone), ethacrynic acid (Edecrin), furosemide (Lasix), hydrochlorothiazide (Microzide, HCTZ), metolazone (Zaroxolyn), torsemide (Demadex), triamterene (Dyrenium, Dyazide, Maxzide)

This is not a complete list of levomilnacipran drug interactions. Ask your doctor or pharmacist for more information.

Levomilnacipran Precautions

Serious side effects have been reported with levomilnacipran including the following:

  • High blood pressure. Your healthcare provider should monitor your blood pressure before and while you are taking levomilnacipran. If you have high blood pressure, it should be controlled before you start taking this medication
  • Increased heart rate
  • Abnormal bleeding: levomilnacipran and other antidepressant medicines may increase your risk of bleeding or bruising, especially if you take blood thinners (eg, warfarin, Coumadin, or Jantoven), a non-steroidal anti-inflammatory drug (NSAID), or aspirin. Tell your healthcare provider right away about any unusual bleeding or bruising.
  • Glaucoma (increased eye pressure)
  • Trouble urinating
  • Hypomania (manic episodes). Tell your doctor if you notice any of the following:
    • greatly increased energy
    • severe trouble sleeping
    • racing thoughts
    • reckless behavior
    • unusually grand ideas
    • excessive happiness or irritability
    • or talking more or faster than usual
  • Seizures or convulsions
  • Discontinuation symptoms: Do not stop levomilnacipran without first talking to your healthcare provider. Stopping levomilnacipran suddenly may cause serious symptoms, including:
    • anxiety
    • irritability
    • high or low mood
    • feeling restless or sleepy
    • headache
    • sweating
    • nausea
    • dizziness
    • electric shock-like sensations
    • tremor
    • confusion
  • Low salt (sodium) levels in the blood. Tell your healthcare provider right away if you have some or all of the following symptoms of low salt (sodium) levels.
    • headache, difficulty concentrating, memory changes, confusion, weakness, and unsteadiness on your feet.
    • Severe or sudden cases may produce hallucinations (seeing or hearing things that are not real), fainting, seizures, and coma.
    • If not treated, severe low sodium levels could cause death.
    • Elderly people may be at greater risk

Levomilnacipran can cause blurred vision. Do not drive or operate heavy machinery until you know how levomilnacipran affects you.

Do not take levomilnacipran if you:

  • are allergic to levomilnacipran or to any of its ingredients
  • Have taken any drugs known as monoamine oxidase inhibitors (MAOIs) within the last 14 days, including the antibiotic linezolid or intravenous methylene blue
  • Have an eye condition called narrow-angle glaucoma that is not being controlled with medical treatment

Levomilnacipran Food Interactions

Medications can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of levomilnacipran, there are no specific foods that you must exclude from your diet when receiving this medication.

Inform MD

Before taking levomilnacipran, tell your doctor about all of your medical conditions. Especially tell your doctor if you:

  • are allergic to levomilnacipran or to any of its ingredients
  • Have high blood pressure or tend to have a fast heart rate
  • Have heart or kidney problems
  • Have or had bleeding problems. Levomilnacipran may increase your risk of bleeding or bruising
  • Have an eye condition called glaucoma
  • Have or had trouble urinating
  • Have or had mania, bipolar disorder (manic depression), seizures or convulsions
  • Have low salt (sodium) levels in your blood
  • Drink alcohol
  • Are pregnant, nursing, or are planning to become pregnant or to breastfeed

Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements.

 

 

Levomilnacipran and Pregnancy

Tell your doctor if you are pregnant or plan to become pregnant.

The FDA categorizes medications based on safety for use during pregnancy. Five categories - A, B, C, D, and X, are used to classify the possible risks to an unborn baby when a medication is taken during pregnancy.

Levomilnacipran falls into category C.  There are no well-controlled studies that have been done in pregnant women. Levomilnacipran should be used during pregnancy only if the possible benefit outweighs the possible risk to the unborn baby.

Levomilnacipran and Lactation

It is not known if levomilnacipran crosses into human milk. Because many medications can cross into human milk and because of the possibility for serious adverse reactions in nursing infants with use of this medication, a choice should be made whether to stop nursing or stop the use of this medication. Your doctor and you will decide if the benefits outweigh the risk of using levomilnacipran.

Levomilnacipran Usage

Take levomilnacipran exactly as prescribed.

Levomilnacipran comes in capsule form and is taken once a day, with or without food.

Do not open, chew, or crush levomilnacipran capsules. Swallow capsules whole.

Avoid drinking alcohol while taking drug levomilnacipran.

It is common for antidepressant medicines such as levomilnacipran to take several weeks before you start to feel better. Do not stop taking levomilnacipran if you do not feel results right away.

Do not stop taking or change the dose of levomilnacipran without talking with your healthcare provider, even if you feel better.

Talk with your healthcare provider about how long you should use levomilnacipran. Take levomilnacipran for as long as your healthcare provider tells you to.

If you miss a dose, take the missed dose as soon as you remember. If it is almost time for the next dose, skip the missed dose and take your next dose at the regular time. Do not take two doses of levomilnacipran at the same time.

Levomilnacipran Dosage

Take this medication exactly as prescribed by your doctor. Follow the directions on your prescription label carefully.

The dose your doctor recommends may be based on the following:

  • other medical conditions you have
  • how you respond to this medication
  • your renal function

The recommended dose range of levomilnacipran for the treatment of depression is 40 mg to 120 mg once daily.

For patients with moderate renal impairment, the dose should not exceed 80 mg once daily.

For patients with moderate renal impairment, the dose should not exceed 40 mg once daily.

 

Levomilnacipran Overdose

If you take too much levomilnacipran, call your healthcare provider or local Poison Control Center, or seek emergency medical attention right away.

Other Requirements

  • Store levomilnacipran at room temperature 68°F to 77°F (20°C to 25°C).
  • Keep this and all medicines out of the reach of children

Levomilnacipran FDA Warning

Suicidality and Antidepressant Drugs

Antidepressants increased the risk of suicidal thoughts and behavior in children, teenagers, and young adults.
In patients of all ages who are started on antidepressant therapy, watch closely for worsening depression and for suicidal thoughts and behaviors. Families and caregivers of patients on antidepressants should talk with the patient's doctor if depression becomes worse.
Levomilnacipran is not approved for use in patients under 18.