Oxaprozin is used to treat osteoarthritis and rheumatoid arthritis. To avoid stomach upset, take with food.

Oxaprozin Overview


Oxaprozin is prescription medication used to treat osteoarthritis and rheumatoid arthritis. Oxaprozin belongs to  a group of medications called nonsteroidal anti-inflammatory medications (NSAIDs). These help by blocking substances in the body that cause inflammation and pain.

Oxaprozin is available in tablet form and is taken usually once per day with food.

Common side effects of oxaprozin include stomach pain, constipation, diarrhea, and indigestion.

Patient Ratings for Oxaprozin

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  • Other
  • Arthritis, Juvenile
  • Arthritis, Rheumatoid
  • Osteoarthritis

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Oxaprozin Cautionary Labels


Uses of Oxaprozin

Oxaprozin is a prescription medication used to treat osteoarthritis, rheumatoid arthritis, and juvenile rheumatoid arthritis.

This medication can be prescribed for other uses. Ask your doctor or pharmacist for more information.

Oxaprozin Brand Names

Oxaprozin may be found in some form under the following brand names:

Oxaprozin Drug Class

Oxaprozin is part of the drug class:

Side Effects of Oxaprozin

Serious side effects have been reported with oxaprozin. See the “Oxaprozin Precautions” section.

Common side effects of oxaprozin include:

  • stomach pain
  • constipation
  • diarrhea
  • indigestion
  • loss of appetite

This is not a complete list of oxaprozin side effects. Ask your doctor or pharmacist for more information.

Tell your doctor if you have any side effect that bothers you or that does not go away.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Oxaprozin FDA Warning

Cardiovascular Risk

  • NSAIDs may cause an increased risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke, which can be fatal. This risk may increase with duration of use. Patients with cardiovascular disease or risk factors for cardiovascular disease may be at greater risk.
  • Oxaprozin is contraindicated for treatment of peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery.

Gastrointestinal Risk

NSAID's cause an increased risk of serious gastrointestinal adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. These events can occur at any time during use and without warning symptoms. Elderly patients are at greater risk for serious gastrointestinal events