Desloratadine & Pseudoephedrine

Desloratadine/pseudoephedrine treats allergies and nasal congestion. It comes in a 12 hour and 24 hour and are taken differently based on which one you are taking. Make sure to follow the directions.

Desloratadine & Pseudoephedrine Overview

Reviewed: September 12, 2012
Updated: 

Desloratadine/pseudoephedrine is a prescription medication used to treat the symptoms of seasonal allergies (sneezing, itching, runny nose, and watery eyes) and nasal congestion. 

Desloratadine/pseudoephedrine is a single tablet that contains 2 medications, desloratadine and pseudoephedrine. Desloratadine is an antihistamine that inhibits histamine release from human mast cells to help relieve sneezing, itching, runny nose, and watery eyes. Pseudoephedrine is a decongestant that shrinks the blood vessels in the nose which results in reduced swelling and mucus formation in the nasal passages to help relieve nasal congestion (stuffy nose).

Desloratadine/pseudoephedrine comes in tablet form and is taken either one or two times a day, depending on the formulation. 
  • Desloratadine/pseudoephedrine 12 Hour is taken two times a day.
  • Desloratadine/pseudoephedrine 24 Hour once daily.
Desloratadine/pseudoephedrine can be taken with or without food. 
 
Some of the common side effects of desloratadine/pseudoephedrine include sore throat, headache, dizziness, and dry mouth. 

Patient Ratings for

How was your experience with ?

First, a little about yourself

Tell us about yourself in a few words?

What tips would you provide a friend before taking ?

What are you taking for?

Choose one
  • Other

How long have you been taking it?

Choose one
  • Less than a week
  • A couple weeks
  • A month or so
  • A few months
  • A year or so
  • Two years or more

How well did work for you?

Did you experience many side effects while taking this drug?

How likely would you be to recommend to a friend?

Desloratadine & Pseudoephedrine Cautionary Labels

precautions

Uses of Desloratadine & Pseudoephedrine

Desloratadine/pseudoephedrine is a prescription medicine used to treat the symptoms of seasonal allergic rhinitis (sneezing, stuffy nose, runny nose and itching of the nose) in patients 12 years and older. 

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

 

Desloratadine & Pseudoephedrine Brand Names

Desloratadine & Pseudoephedrine may be found in some form under the following brand names:

Desloratadine & Pseudoephedrine Drug Class

Desloratadine & Pseudoephedrine is part of the drug class:

Side Effects of Desloratadine & Pseudoephedrine

Desloratadine/pseudoephedrine may cause serious side effects, including:

  • Cardiovascular and central nervous system effects, such as
    • unable to sleep (insomnia)
    • dizziness
    • weakness
    • tremor
    • irregular heart beat
    • seizure
    • low blood pressure
  • Increased sleepiness or tiredness can happen if you take more desloratadine/pseudoephedrine than your doctor prescribed to you.
  • Allergic reactions. Stop taking desloratadine/pseudoephedrine and call your doctor right away or get emergency help if you have any of these symptoms:
    • rash
    • itching
    • hives
    • swelling of your lips, tongue, face, and throat
    • shortness of breath or trouble breathing

The most common side effects of desloratadine/pseudoephedrine include:

  • unable to sleep (insomnia)
  • sore throat
  • headache
  • dizziness
  • dry mouth
  • nausea
  • tiredness
  • loss of appetite
  • sleepiness
  • nervousness
  • restlessness

Tell your doctor if you have any side effect that bothers you or that does not go away.

These are not all of the possible side effects of desloratadine/pseudoephedrine. For more information, ask your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Desloratadine & Pseudoephedrine Interactions

Tell your doctor about all the medicines your take, including prescription and non-prescription medicines, vitamins and herbal supplements. Desloratadine/pseudoephedrine may affect the way other medicines work, and other medicines may affect how desloratadine/pseudoephedrine extended release tablets work. Especially tell your doctor if you take:

  • Monoamine Oxidase Inhibitors (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), tranylcypromine (Parnate), selegiline (Emsam, Eldepryl, Zelapar), and rasagiline (Azilect). You should not use desloratadine/pseudoephedrine if you take a MAOI or within 2 weeks of stopping an MAOI.
  • methyldopa
  • reserpine (Serpalan)
  • ketoconazole (Nizoral)
  • digitalis (Digoxin, Lanoxicaps, Lanoxin) ketoconazole (Nizoral)
  • erythromycin (Ery-tab, Eryc, PCE)
  • azithromycin (Zithromax, Zmax)
  • antihistamines
  • other decongestant medicines

Know the medicines you take. Keep a list of your medicines and show it to your doctor and pharmacist when you get a new medicine.

Desloratadine & Pseudoephedrine Precautions

Do not take desloratadine/pseudoephedrine if you:

  • are allergic to desloratadine or pseudoephedrine sulfate or any of the ingredients in desloratadine/pseudoephedrine
  • are allergic to loratadine (Alavert, Claritin)
  • have narrow angle glaucoma
  • have problems with urination (urinary retention)
  • take a Monoamine Oxidase Inhibitor (MAOI) medicine to treat depression, or if you stopped taking an MAOI medicine within the last 2 weeks. Ask your doctor or pharmacist if you are not sure if you take an MAOI medicine.
  • have severe high blood pressure
  • have severe heart disease

Talk to your doctor before taking this medicine if you have any of these conditions.

Desloratadine & Pseudoephedrine Food Interactions

Medications can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of desloratadine/pseudoephedrine, there are no specific foods that you must exclude from your diet when receiving this medication.

Inform MD

Before you take desloratadine/pseudoephedrine, tell your doctor if you:

  • have any of the conditions listed in the section "Drug Precautions".
  • diabetes
  • hyperthyroidism
  • have prostate problems
  • have liver or kidney problems
  • have any other medical conditions
  • are pregnant or plan to become pregnant. It is not known if desloratadine/pseudoephedrine will harm your unborn baby. Talk to your doctor if you are pregnant or plan to become pregnant.
  • are breastfeeding or plan to breastfeed. Desloratadine/pseudoephedrine can pass into your breast milk. Talk to your doctor about the best way to feed your baby if you take desloratadine/pseudoephedrine.

Tell your doctor about all the medicines your take, including prescription and non-prescription medicines, vitamins and herbal supplements. 

Desloratadine & Pseudoephedrine and Pregnancy

Tell your doctor if you are pregnant or plan to become pregnant.

The FDA categorizes medications based on safety for use during pregnancy. Five categories - A, B, C, D, and X, are used to classify the possible risks to an unborn baby when a medication is taken during pregnancy.

Desloratadine/pseudoephedrine falls into category C. No studies have been done in animals, and no well-controlled studies have been done in pregnant women. Desloratadine/pseudoephedrine should be given to a pregnant woman only if clearly needed.

It is not known if desloratadine/pseudoephedrine will harm your unborn baby. Talk to your doctor if you are pregnant or plan to become pregnant.

Desloratadine & Pseudoephedrine and Lactation

Tell your doctor if you are breastfeeding or plan to breastfeed. Desloratadine/pseudoephedrine can pass into your breast milk. Talk to your doctor about the best way to feed your baby if you take desloratadine/pseudoephedrine.

Desloratadine & Pseudoephedrine Usage

Take desloratadine/pseudoephedrine exactly as your doctor tells you to take it.

  • Desloratadine/pseudoephedrine can be taken with or without food.
  • Swallow desloratadine/pseudoephedrine tablets whole. Do not break, crush, or chew desloratadine/pseudoephedrine tablets before swallowing. If you cannot swallow desloratadine/pseudoephedrine tablets whole, tell your doctor. You may need a different medicine.

Desloratadine & Pseudoephedrine Dosage

Take this medication exactly as prescribed by your doctor. Follow the directions on your prescription label carefully.

The recommended dose of desloratadine/pseudoephedrine 12 Hour is one tablet 2 times a day (every 12 hours).

The recommended dose of desloratadine/pseudoephedrine 24 Hour is one tablet once daily.

 

 

Desloratadine & Pseudoephedrine Overdose

If you take too much desloratadine/pseudoephedrine, call your healthcare provider or local Poison Control Center, or seek emergency medical attention right away.

Other Requirements

  • Store desloratadine/pseudoephedrine 12 Hour tablets at 59°F to 86°F (15°C to 30°C).
  • Store desloratadine/pseudoephedrine 24 Hour tablets at 77°F (25°C).
  • Keep desloratadine/pseudoephedrine dry and out of the light.

Keep desloratadine/pseudoephedrine and all medicines out of the reach of children.