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May 1, 2018
 

Melatonin Improves Energy Production

Mitochondria are the energy producers in our cells. They are the power plants for the body. We need healthy mitochondria for energy production.

Scientists had eight diabetic rats and eight lean rats receive or not receive melatonin in their drinking water for six weeks to evaluate the effect on mitochondrial function.

The researchers — whose study was published in the Journal of Pineal Research — found that mitochondrial production increased in both lean and diabetic rats when they were given melatonin.

Furthermore, all of the melatonin-treated rats showed a reduction in oxidative markers.

We all need healthy mitochondria, which are very sensitive to oxidative stressors and nutrient deficiencies.

Melatonin is a hormone naturally produced in the body’s pineal gland, which is located in the brain. It is produced at night when you are sleeping.

I frequently recommend melatonin to help patients sleep better at night. It is an incredibly safe supplement. Far too many people suffer from mitochondrial and poor sleep issues due to a lack of melatonin.

Supplementing with melatonin has a few adverse effects which include next-morning drowsiness or more rarely, nightmares.

Side effects with melatonin use can easily be rectified by lowering the dose.

When I prescribe it, I usually recommend 0.5 to 3 mg per night.

Researchers found in a recent study that people who were severely obese or recently lost weight were linked to more rapidly progressing forms rheumatoid arthritis.

The findings were published Sunday in Arthritis Care & Research.

"While patients and rheumatologists may be focused mostly on disease activity, we should also consider this common condition, which can contribute to problems that are usually attributed to the arthritis itself," Dr. Joshua Baker, a researcher at Penn, said in a press release. "In addition, unintentional weight loss should alert us that the patient may be becoming frail and is at risk for developing new disability."

Baker and colleagues analyzed data on 23,323 patients with rheumatoid arthritis whose information was collected in the National Data Bank of the Rheumatic Diseases, as well as 1,697 from the Veterans Affairs RA registry.

At enrollment, disability scores were higher among severely obese patients than for those who were overweight.

The researchers said the worsening disability was not associated with features of their arthritis, including inflammation in joints, noting the disability worsened more quickly in those that had lost wright.

"We believe that this is because when people get older and acquire illnesses, they tend to lose weight. Therefore, the important weight loss in this study is unintentional," Baker said.

"So, this study suggests that patients with rheumatoid arthritis and obesity would benefit from intentional weight loss through a comprehensive management strategy; however, when we see that someone is losing weight without trying, it's probably a poor prognostic sign, especially if they are already thin."

The researchers said health providers should recognize unintentional weight loss as a sign of trouble and refer patients for strength training, physical therapy and other programs.


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