Xuriden

treats a rare metabolic disorder called hereditary orotic aciduria. It is the only medication approved for this condition.

Xuriden Overview

Reviewed: September 8, 2015
Updated: 

Xuriden is a prescription medication used to treat hereditary orotic aciduria, a rare metabolic disorder in which the body can not make uridine. Xuriden is considered an orphan drug, because it treats a rare disease. 

Xuriden works by replacing uridine. 

It is available as oral granules that can be mixed with food or in milk or infant formula. It is usually administered once daily.

Do not chew the granules.

No side effects were observed in patients treated with Xuriden for up to nine months.

 

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Xuriden Cautionary Labels

precautionsprecautions

Uses of Xuriden

Xuriden is a prescription medication used to treat hereditary orotic aciduria, a rare metabolic disorder in which the bosy can not make uridine.

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

Side Effects of Xuriden

There are no adverse reactions that have been reported with Xuriden. 

If you notice a side effect, tell your doctor. 

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

 

 

Xuriden Interactions

No drug interactions have been reported by the manufacturer. However, you should tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements. Not all drug interactions are known or reported and new drug interactions are continually being reported.

Theoretically Xuriden may interact with medications that use the p-glycoprotein transporter. Tell your doctor if you take medications such as digoxin (Lanoxin), loperamide (Imodium), quinidine (Cardioquine, Quinact, Duraquin), vinblastine (Velban), fexofenadine (Allegra), indinavir (Crixivan), colchicine (Colcrys), topotecan (Hycamtin), and paclitaxel (Abraxane, Onxol, Taxol).

 

 

Xuriden Precautions

No precautions have been determined by the manufacturer.

Do not take Xuriden if you are allergic to Xuriden or any of its ingredients. 

Xuriden Food Interactions

Medications can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of Xuriden, there are no specific foods that you must exclude from your diet when receiving this medication.

 

Inform MD

Before taking Xuriden, tell your doctor about all of your medical conditions. Especially tell your doctor if you:

  • are allergic to Xuriden or to any of its ingredients
  • are pregnant or plan to become pregnant
  • are breastfeeding or plan to breastfeed

Xuriden and Pregnancy

Tell your doctor if you are pregnant or plan to become pregnant.

There are no well-done studies that have been done in humans with Xuriden. In animal studies, pregnant animals were given this medication, and the babies did not show any medical issues related to this medication.

 

 

Xuriden and Lactation

Tell your doctor if you are breastfeeding or plan to breastfeed.

It is not known if Xuriden crosses into human milk. in addition, there is no data on Xuriden's effect on the breastfed infant or on milk production. The doctor will determine the devlopment and health benefits of breastfeeding as well as the mother's clinical need for Xuriden and any potential effects on the breastfed infant from Xuriden or from the underlying maternal condition. 

Xuriden Usage

Take Xuriden exactly as prescribed.

Xuriden comes as oral granules that can be mixed with food or in milk or infant formula. It is usually administered once daily.

If you miss a dose, take the missed dose as soon as you remember. If it is almost time for the next dose, skip the missed dose and take your next dose at the regular time. Do not take two doses of Xuriden at the same time.

Preparation

  • Measure the dose using either a scale accurate to at least 0.1 gram, or a graduated teaspoon, accurate to the fraction of the dose to be administered.
  • Once the measured dose has been removed from the Xuriden packet, discard the unused portion of granules.
  • Do not use any granules left in the open packet.

Administration with Food

1. Place 3 to 4 ounces of applesauce, pudding or yogurt in a small clean container.

2. Mix the measured amount of granules in the applesauce, pudding or yogurt

3. Swallow applesauce/pudding/yogurt immediately. Do not chew the granules. Do not save the applesauce/pudding/yogurt for later use.

4. Drink at least 4 ounces of water.

Administration in Milk or Infant Formula

Xuriden can be mixed with milk or infant formula instead of the soft foods described above for patients receiving up to 3/4 teaspoon (2 grams) of Xuriden. After weighing the dose of Xuriden: 

1. Pour 5 mL of milk or infant formula into a 30 mL medicine cup.

2. Insert the tip of the oral syringe into the medicine cup and draw up 5 mL of milk/infant formula into the syringe.

3. Hold the syringe with the tip pointing upward. Pull down on the plunger until the plunger reaches 10 mL. This will add air to the syringe.

4. Place the cap over the tip of the syringe. Then invert the syringe so the syringe tip is pointing down, and remove the plunger.

5. Pour the measured amount of Xuriden granules into the syringe barrel and reinsert the syringe plunger. Do not push up on the plunger.

6. Gently swirl the syringe to mix the Xuriden granules with the liquid.

7. Turn the syringe so the syringe tip is pointing up. Then remove the syringe cap and push up on the plunger until the plunger reaches the 5 mL mark. This will remove air from the syringe.

8. Place the tip of the syringe in the patient’s mouth between the cheek and gum at the back of the mouth. Gently push the plunger all the way down.

9. Refill the syringe with another 5 mL of milk/infant formula.

10. Gently swirl the syringe to rinse any remaining Xuriden granules from the syringe barrel.

11. Place the tip of the syringe in the patient’s mouth between the cheek and gum at the back of the mouth. Gently push the plunger all the way down.

12. Follow with a bottle of milk or infant formula, if desired.

Xuriden Dosage

Take this medication exactly as prescribed by your doctor. Follow the directions on your prescription label carefully.

The dose your doctor recommends may be based on the following:

  • the condition being treated
  • how you respond to this medication
  • your weight

The starting dosage is 60 mg/kg once daily; the dose may be increased to 120 mg/kg (not to exceed 8 grams) once daily if needed. 

Xuriden Overdose

If you take too much Xuriden, call your healthcare provider or local Poison Control Center, or seek emergency medical attention right away.

 

Other Requirements

  • Store Xuriden at controlled room temperature, 25°C (77°F).
  • Keep this and all medicines out of the reach of children.