Xofigo

Xofigo treats prostate cancer that has spread into the bone.

Xofigo Overview

Reviewed: May 15, 2013
Updated: 

Xofigo is an agent used to treat prostate cancer that has spread into the bone. Xofigo is an alpha particle-emitting isotope. It works by integrating within bone and emitting energy. This energy wave disrupts cancer cell DNA and destroys the cell.

Xofigo comes in an liquid form to be injected into the vein (IV) by a healthcare professional.

Common side effects include nausea, diarrhea, vomiting, and swelling.

 

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Xofigo Cautionary Labels

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Uses of Xofigo

Xofigo is an agent used to treat prostate cancer that has spread into the bone. It targets only cancer cells that have spread into the bone.

This agent may be prescribed for other uses. Ask your doctor or pharmacist for more information.
 

Xofigo Drug Class

Xofigo is part of the drug class:

Side Effects of Xofigo

Common side effects include the following:

  • nausea
  • diarrhea
  • vomiting
  • swelling
  • low blood counts

This is not a complete list of Xofigo's side effects. Ask your doctor or pharmacist for more information.

Tell your doctor if you have any side effect that bothers you or that does not go away.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Xofigo Interactions

No drug interactions have been studied by the manufacturer. However, you should tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements. Not all drug interactions are known or reported and new drug interactions are continually being reported.

Xofigo Precautions

Serious side effects have been reported with Xofigo, and certain precautions should be followed:

  • lowered blood count. This may cause certain symptoms and may increase the risk that you will develop a serious or life-threatening infection or bleeding. If you experience any of the following symptoms, call your doctor immediately: fever, chills, sore throat, ongoing cough and congestion, or other signs of infection; unusual bleeding or bruising; bloody or black, tarry stools; bloody vomit; or vomiting blood or brown material that resembles coffee grounds.
  • Report signs of dehydration, including lowered blood pressure, inability to urinate, or unusual fatige.

Do not receive Xofigo if you:

  • are allergic to Xofigo or to any of its ingredients
  • are pregnant

 

Xofigo Food Interactions

Medications can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of Xofigo, there are no specific foods that you must exclude from your diet.

Inform MD

Before receiving Xofigo, tell your doctor about all of your medical conditions. Especially tell your doctor if you:

  • are allergic to Xofigo or to any of its ingredients
  • have kidney problems
  • have a blood disorder
  • are pregnant or breastfeeding
  • Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements.

 

Xofigo and Pregnancy

Tell your doctor if you are pregnant or plan to become pregnant.

The FDA categorizes medications based on safety for use during pregnancy. Five categories - A, B, C, D, and X, are used to classify the possible risks to an unborn baby when a medication is taken during pregnancy.

This medication falls into category X. Xofigo can cause harm to the fetus (unborn baby) if you take this and are pregnant. Xofigo is not indicated for use in women. Xofigo is contraindicated in women who are or may become pregnant. If this drug is used during pregnancy, or if you become pregnant while taking this drug, be aware of the potential hazard to the fetus.

Xofigo and Lactation

Tell your doctor if you are breastfeeding or plan to breastfeed.

It is not known if Xofigo crosses into human milk. Because many medications can cross into human milk and because of the possibility for serious adverse reactions in nursing infants with use of this medication, a choice should be made whether to stop nursing or stop the use of this medication. Your doctor and you will decide if the benefits outweigh the risk of using this medication.

Xofigo Usage

  • This medication comes in an liquid form to be injected into the vein (IV) by a healthcare professional.
  • Follow good hygiene practices while receiving this medication and for at least 1 week after the last injection in order to minimize radiation exposure from bodily fluids. Whenever possible, use a toilet and the toilet should be flushed several times after each use. Clothing soiled with patient fecal matter or urine should be washed promptly and separately from other clothing. If a caregiver is assisting you, he/she should use universal precautions for patient care such as gloves and barrier gowns when handling bodily fluids to avoid contamination.

Xofigo Dosage

Take this medication exactly as prescribed by your doctor. Follow the directions on your prescription label carefully. The dose your doctor recommends may be based on the following:

  • the condition being treated
  • other medical conditions you have
  • other medications you are taking
  • how you respond to this medication
  • your weight
  • your height
  • your age
  • your gender

The dose regimen is 50 kBq (1.35 microcurie) per kilogram of body weight, given every 4 weeks for 6 injections.

Xofigo Overdose

Since this medication is administered by a healthcare provider in a medical setting, it is unlikely that an overdose will occur. However, if overdose is suspected, seek emergency medical attention.
 

Other Requirements

Keep all appointments with your doctor and the laboratory.